The Pathobiology of Diabetic Complications

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FIG. 11.
FIG. 11.

Insulin resistance causes mitochondrial overproduction of ROS in macrovascular endothelial cells by increasing FFA flux and oxidation. From Hofmann S, Brownlee M: Biochemistry and molecular cell biology of diabetic complications: a unifying mechanism. In Diabetes Mellitus: A Fundamental and Clinical Text. 3rd ed. LeRoith D, Taylor SI, Olefsky JM, Eds. Philadelphia, Lippincott Williams & Wilkins, p. 1441–1457, 2004.

This Article

  1. Diabetes vol. 54 no. 6 1615-1625