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Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans

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FIG. 1.
FIG. 1.

Plasma concentrations of glucose (A), insulin (B), and C-peptide (C) in five healthy subjects studied in the fasting state and during an intravenous glucose infusion (2 mg · kg−1 · min−1). Plasma glucose levels were obtained from blood samples from an arterialized vein. Insulin and C-peptide concentrations were derived from blood samples obtained from an arterialized peripheral vein (dotted lines) and from the hepatic vein (continued lines). Values are presented as means ± SEM (n = 5). P values were calculated by repeated-measures ANOVA.

This Article

  1. Diabetes vol. 54 no. 6 1649-1656