Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans
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Calculated C-peptide secretion rates (A) and insulin delivery rates from the liver (B) in five healthy subjects studied in the fasting state and during an intravenous glucose infusion (2 mg · kg−1 · min−1). Values are presented as means ± SEM (n = 5). P values were calculated by repeated-measures ANOVA.