Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans
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Absolute hepatic clearance rates (A) and fractional insulin extraction (B) in five healthy subjects studied in the fasting state and during an intravenous glucose infusion (2 mg · kg−1 · min−1). Data represent means of 40 individual values in each subject during the respective experimental periods. P values were calculated by paired ANOVA.