Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans
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Insulin secretion rates (A) and insulin plasma concentrations (B) from the hepatic vein in a representative nondiabetic individual studied over 40 min in the fasting state. C: Corresponding serial insulin clearance data from the same individual. Fluctuations in the solid line at the top of the panel
show the result of the Cluster analysis. Each peak of this line represents a significant upstroke in the time series of insulin
clearance. D: Corresponding plasma insulin concentration from the arterialized peripheral vein in the same individual.