Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans
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Cross-correlation analysis of C-peptide secretion rates and hepatic insulin clearance in five healthy subjects studied over
40 min in the fasting state (A) and during an intravenous glucose infusion (2 mg · kg−1 · min−1) (B). These data are presented as means ± SEM and illustrate that changes in C-peptide secretion occur almost simultaneously
with changes in insulin clearance (P < 0.05).