Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans

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FIG. 6.
FIG. 6.

Linear regression analysis between insulin clearance and respective insulin burst mass (A and B), insulin burst amplitude (C and D), and the basal, nonpulsatile insulin secretion (E and F) determined in the overnight-fasting state (•) and during an intravenous glucose infusion (♦). Left panels indicate the associations determined from the hepatic vein, and right panels associations with samples collected in arterialized peripheral blood.

This Article

  1. Diabetes vol. 54 no. 6 1649-1656