Long-term function of Adv-LacZ- and Adv-CA-Akt–transduced islet grafts. Blood glucose in three of six randomly selected mice
transplanted with 1,500 Adv-LacZ–or 1,500 Adv-CA-Akt–transduced IEQs was measured for a period of 6 months. The posttransplant
blood glucose values in mice transplanted with 1,500 Adv-CA-Akt–transduced IEQs were significantly (P < 0.05) lower for the entire 6-month period than the blood glucose values obtained after the transplant of 1,500 Adv-LacZ–transduced
human IEQs. In the group of mice transplanted with 1,500 Adv-LacZ IEQs, one hyperglycemic transplanted mouse died at 175 days
after the transplant. At day 180, UNX was performed in mice transplanted with Adv-CA-Akt–transduced islets, and the blood
glucose returned immediately to pretransplant diabetic levels. Results are means ± SE.