Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes

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FIG. 1.
FIG. 1.

MAPKerk-dependent downregulation of MTP expression by naringenin and insulin. HepG2 cells in LPDS media were preincubated (30 min) in the absence (−) or presence (+) of UO126 (10 μmol/l) or UO124 (10 μmol/l) (A), or ± SB203580 (10 μmol/l) or SB202474 (10 μmol/l) (B), followed by a 6-h incubation ± naringenin (100 μmol/l) or insulin (100 nmol/l). MTP mRNA abundances are means ± SE for at least four experiments. *P < 0.05, **P < 0.01 compared with control; †P < 0.01 compared with naringenin or insulin.

This Article

  1. Diabetes vol. 54 no. 6 1676-1683