Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 2.
FIG. 2.

Naringenin and insulin enhance the phosphorylation of ERK1/2 and MAPKp38. HepG2 cells in serum-free media were incubated ± naringenin (100 μmol/l) or insulin (100 nmol/l) for 15, 30, or 60 min. Total and phosphorylated ERK1/2 (A) and total and phosphorylated MAPKp38 (B) were measured by immunoblotting and are presented as the ratio of phosphorylated form to total protein (relative to control). Values are means ± SE for at least three experiments. *P < 0.05, **P < 0.01 compared with control.

This Article

  1. Diabetes vol. 54 no. 6 1676-1683