Effects of AR deficiency on adipocyte-derived adipokine. A: Fed leptin concentrations in 8-, 25-, or 35-week-old mice. B: Relationship between fed leptin concentrations and body weight of 35-week-old mice. C: Adiponectin concentrations in 35-week-old mice. D: TNF-α concentrations in 35-week-old mice. Values are the means ± SE from five mice per group. In D, n = 8 for wild-type mice and n = 7 for AR−/y mice. Regression lines for both groups are shown. *P < 0.05, **P < 0.01, AR−/y vs. wild type. N.S., no significance; WT, wild type.