Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor

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FIG. 4.
FIG. 4.

Aging AR−/y mice developed leptin resistance but not younger mice. Two groups of 35- or 20-week-old mice received an intraperitoneal injection of either leptin (5 μg/g body wt) or isotonic saline. A: Food intake per 24 h of 35-week-old mice. B: Weight changes per 24 h of 35-week-old mice. C: Food intake per 24 h of 20-week-old mice. D: Weight changes per 24 h of 20-week-old mice. Values are the means ± SE from 3–4 mice per group. *P < 0.05, wild type with leptin vs. control; †P < 0.05, leptin treatment vs. control; ††P < 0.001, leptin treatment vs. control. N.S., no significance; WT, wild type.

This Article

  1. Diabetes vol. 54 no. 6 1717-1725