Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor

TABLE 2

Physiological and metabolic parameters of 35-week-old study groups

Genotype
Male wild type Female wild type AR−/y
Mice (n) 9 10 9
Body weight (g) 33.15 ± 1.2 25.81 ± 0.44 39.06 ± 2.7*
Gonadal fat/body (%) 2.21 ± 0.14 0.34 ± 0.08 3.29 ± 0.23*
Serum total triglycerides (mmol/l) 0.30 ± 0.04 0.32 ± 0.08 0.67 ± 0.1
Serum nonesterified fatty acids (mEq/l) 0.25 ± 0.02 0.25 ± 0.02 0.71 ± 0.04
Serum cholesterol (mmol/l) 2.28 ± 0.05 2.28 ± 0.06 2.44 ± 0.05
Fasting blood glucose (mmol/l) 6.46 ± 0.31 6.41 ± 0.27 7.94 ± 0.38*
Fed blood glucose (mmol/l) 14.03 ± 0.54 14.93 ± 0.29 19.75 ± 0.78
Fasting serum insulin (ng/ml) 0.55 ± 0.13 0.53 ± 0.33 0.88 ± 0.33*
Fed serum insulin (ng/ml) 0.92 ± 0.17 1.12 ± 0.14 1.54 ± 0.16*
  • Data are the means ± SE. After a 14-h fast, animals were killed.

  • *

    * P < 0.05,

  • P < 0.01, and

  • P < 0.001, AR vs. male wild type.

This Article

  1. Diabetes vol. 54 no. 6 1717-1725