β-Cell Function Across the Spectrum of Glucose Tolerance in Obese Youth

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FIG. 4.
FIG. 4.

Relation of insulin sensitivity and the β-cell glucose sensitivity of second-phase secretion. Scatterplot of glucose sensitivity of β-cell second-phase secretion (σ2nd; y axis) vs. insulin sensitivity (Si; x axis) in adolescents with NGT (♦), IGT (▪), and type 2 diabetes (T2DM) (▴). The two curves are generated by the following equation found by nonlinear regression analysis, as described in research design and methods: σ2nd = A× (1 + ds × C) × ISB, where ds = 0 in NGT and IGT subjects and ds = 1 in type 2 diabetes subjects, IS = insulin sensitivity, A = 36.7 (95% CI 26.3–66.1), B = −0.37 (−0.49 to −0.10), and C = −0.40 (−0.57 to −0.25).

This Article

  1. Diabetes vol. 54 no. 6 1735-1743