β-Cell Function Across the Spectrum of Glucose Tolerance in Obese Youth

TABLE 3

Weighted residuals (i.e., difference between measured and model predicted C-peptide concentration divided by the SD of C-peptide measurement) of model fit to plasma C-peptide experimental data of the hyperglycemic clamps performed in NGT, IGT, and type 2 diabetic adolescents

Time C-peptide weighted residuals
NGT (n = 30) IGT (n = 22) DM2 (n = 10)
2 −0.34 ± 0.36 −0.06 ± 0.44 −0.08 ± 0.11
4 0.41 ± 0.38 0.31 ± 0.38 0.28 ± 0.58
6 0.18 ± 0.47 −0.04 ± 0.34 0.14 ± 0.55
8 −0.37 ± 0.52 −0.41 ± 0.33 −0.45 ± 0.34
10 −0.16 ± 0.63 −0.07 ± 0.39 0.10 ± 0.57
20 0.50 ± 0.61 0.58 ± 0.61 0.32 ± 0.37
40 0.15 ± 0.75 −0.39 ± 0.75 −0.18 ± 0.65
60 −0.30 ± 0.59 −0.05 ± 0.66 −0.21 ± 0.50
80 −0.20 ± 0.70 0.04 ± 0.66 −0.10 ± 0.83
100 −0.02 ± 0.65 0.19 ± 0.57 0.34 ± 0.42
120 0.58 ± 0.80 0.19 ± 0.65 0.23 ± 0.77
  • Data are means ± SD. The weighted residuals are a quantitative assessment of the goodness-of-fit of the models to the data: a theorically perfect fit should generate weighted residuals with mean of 0 and SD of 1.

This Article

  1. Diabetes vol. 54 no. 6 1735-1743