Prevention of Type 1 Diabetes with Major Histocompatibility Complex–Compatible and Nonmarrow Ablative Hematopoietic Stem Cell
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Diabetes-free survival of lethally irradiated NOD mice transplanted with (NOD×B6.H-2g7)F1 bone marrow. Recipients of 6 × 106 (NOD×B6.H-2g7)F1 bone marrow cells (○) were protected from diabetes as were control NOD mice that received B6.H-2g7 bone marrow (▴). Control recipients of syngeneic NOD bone marrow (•) all developed hyperglycemia.