Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells
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Effect of glucose and insulin on glucagon secretion in αTC1-9 cells (A) and intact mouse islets (B–D). A and B: Glucagon secretion was measured at the given concentration of glucose, in the absence (○) or in the presence (•) of 17 nmol/l
insulin in αTC1-9 cells (A) or in intact mouse islets (B). C: Impact of wortmannin on glucagon secretion in the absence or presence of insulin at 0.5 mmol/l (□) or 10 mmol/l (▪) glucose
(G). D: Insulin secretion from islets measured in samples from B. The scale bars illustrate the concentration of insulin released after 1 h of incubation. Values are means ± SE for four
independent experiments. *P < 0.05 for the effects of 17 nmol/l insulin (A and B).