Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells

TABLE 2

Glucagon secretion from mouse islets

0.5 mmol/l glucose (% of content/h) 10 mmol/l glucose (% of content/h)
No additions 0.095 ± 0.011 0.055 ± 0.008 *
17 nmol/l insulin 0.053 ± 0.008 * 0.054 ± 0.009 *
17 nmol/l insulin + 30 μmol/l ZnCl2 0.069 ± 0.010 0.056 ± 0.006 *
30 μmol/l ZnCl2 0.097 ± 0.012 0.060 ± 0.010 *
  • Data are the means ± SE for seven separate experiments. The effects of insulin, wortmannin, or ZnCl2 were tested on glucagon secretion at either 0.5 or 10 mmol/l glucose in mouse islets.

  • *

    * P ≤ 0.05 vs. 0.5 mmol/l glucose.

This Article

  1. Diabetes vol. 54 no. 6 1789-1797