Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy

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FIG. 1.
FIG. 1.

Metallothionein prevention of diabetes-induced cardiac structural changes and serum CPK increase. Heart tissues from control and diabetic mice 2 weeks after STZ treatment were examined under the light microscope after hematoxylin-eosin staining (A, ×60) and under electron microscope (B, ×11,000). Morphological changes were described in the text. C: Serum was collected from wild-type and MT-TG control or diabetic mice at the indicated times to measure serum CPK using a CPK kit as described in research design and methods. Treatment groups that do not share the same letter were significantly different (P < 0.05). WT, wild type; LP, lipid droplets; Nu, nuclei; M, mitochondria.

This Article

  1. Diabetes vol. 54 no. 6 1829-1837