Metallothionein prevention of diabetes-induced cardiac structural changes and serum CPK increase. Heart tissues from control
and diabetic mice 2 weeks after STZ treatment were examined under the light microscope after hematoxylin-eosin staining (A, ×60) and under electron microscope (B, ×11,000). Morphological changes were described in the text. C: Serum was collected from wild-type and MT-TG control or diabetic mice at the indicated times to measure serum CPK using
a CPK kit as described in research design and methods. Treatment groups that do not share the same letter were significantly different (P < 0.05). WT, wild type; LP, lipid droplets; Nu, nuclei; M, mitochondria.