Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy

TABLE 1

General parameters of STZ-induced diabetes in wild-type and MT-TG mice

Groups WBGL (mmol/l) BWG (g) HWR (%) KWR (%) HbA1c (%) Serum TBARS (nmol/ml)
Wild type
    Control 4.2 ± 0.3 1.28 ± 0.36 0.45 ± 0.02 0.75 ± 0.04 2.10 ± 0.04 11.0 ± 0.3
    Diabetes 15.0 ± 0.3* −0.61 ± 0.65 0.46 ± 0.05 0.92 ± 0.05* 3.07 ± 0.15* 16.6 ± 0.8*
    Diabetes/insulin 7.6 ± 1.1 1.25 ± 0.50 0.45 ± 0.10 0.77 ± 0.45 2.21 ± 0.56 12.5 ± 1.3
MT-TG
    Control 4.1 ± 0.2 1.17 ± 0.28 0.44 ± 0.01 0.76 ± 0.03 2.09 ± 0.12 12.4 ± 1.0
    Diabetes 14.9 ± 0.2* −0.02 ± 0.87 0.45 ± 0.02 0.90 ± 0.05* 2.90 ± 0.20* 16.4 ± 1.4*
  • Data are means ± SE (12 mice at least for each group except for diabetes/insulin group with 7 mice). BWG, body weight gain; HWR or KWR, ratio of the heart or kidney weight, respectively, to body weight; WBGL, fasting whole-blood glucose level measured from blood samples obtained from tail vein.

  • *

    * P < 0.05 vs. corresponding control;

  • P < 0.05 vs. wild-type diabetic group.

This Article

  1. Diabetes vol. 54 no. 6 1829-1837