Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 4.
FIG. 4.

GCCR and POMC expression in the pituitary gland remained unchanged after GCCR ASO treatment in ZDF rats. Rats were dosed with saline (□), GCCR ASO 37.5 mg/kg (▪), or control ASO 37.5 mg/kg ([cjs2112]) twice a week for 4 weeks. Total mRNA was prepared from the pituitary gland and analyzed for the expression of GCCR (A) and POMC (B) by RT-PCR (n = 4 per group). Data are expressed as means ± SE relative to saline-treated controls.

This Article

  1. Diabetes vol. 54 no. 6 1846-1853