Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism

TABLE 1

Effect of GCCR ASO on adipocytokines and insulin

Resistin (ng/ml) TNF-α (pg/ml) Insulin (ng/ml) Adipo-nectin (μg/ml) Inter-leukin-6 (pg/ml)
Treatment
    Saline 22 ± 1.4 42 ± 2.3 43 ± 5.9 8.73 ± 0.14 6.27 ± 0.74
    GCCR     ASO 18 ± 0.9 27 ± 0.8* 16 ± 1.4* 8.72 ± 0.35 5.37 ± 1.22
  • Data are means ± SE.

This Article

  1. Diabetes vol. 54 no. 6 1846-1853