Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism

TABLE 2

Plasma corticosterone (ng/ml) in diabetic rodents

ob/ob mice db/db mice ZDF rats HFD-STZ rats
Treatment
    Control ASO 319 ± 24 218 ± 23 30 ± 6 95 ± 23
    GCCR ASO 257 ± 50 196 ± 75 35 ± 0.8 117 ± 46
  • Data are means ± SE.

This Article

  1. Diabetes vol. 54 no. 6 1846-1853