Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J × SM/J Murine Model of Obesity

TABLE 4

Pfkp gene

Position 129 201 782 849 874 1050 1281 1704 2028 2031 2046 2082 2310 2329 2345
C57BL C G G C G A C A A G G G T T A
LG/J C A A T A C T G G T A C C C G
SM/J T G G C G A C A A G G G T T A
Codon 3 3 2 3 1 3 3 3 3 3 3 3 3 1 2
AA R-R V-V R-Q I-I V-M A-A A-A S-S A-A P-P R-R E-D S-S S-P E-G
Prob 5 4 1 4 −2 4 4 4 4 7 5 2 4 −1 −2
SIFT 0.10 0.03* 0.53 0.15 0.27
  • Position represents a base pair position from the 5′ end of the Pfkp gene. Sequence data from C57BL/6J mouse are from Ensembl Mouse Build 32. Codon signifies which codon the respective position represents, and AA signifies resulting amino acid change, if any. Prob signifies the log10 odds of amino acid changes derived from the BLOSUM62 matrix. SIFT signifies probabilities of amino acid changes having a significant deleterious effect. *Statistical significance at the 5% level. Amino acid changes between LG/J and SM/J mice are highlighted in bold.

This Article

  1. Diabetes vol. 54 no. 6 1863-1872