Table of Contents

• Catherine Gallou-Kabani and
• Claudine Junien

Nutritional Epigenomics of Metabolic Syndrome: New Perspective Against the Epidemic

• David Faeh,
• Kaori Minehira,
• Jean-Marc Schwarz,
• Raj Periasamy,
• Seongsoo Park,
• and Luc Tappy

Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men

• Hui Chen,
• Gail Sullivan,
• and Michael J. Quon

Assessing the Predictive Accuracy of QUICKI as a Surrogate Index for Insulin Sensitivity Using a Calibration Model

• Lauren M. Sparks,
• Hui Xie,
• Robert A. Koza,
• Randall Mynatt,
• Matthew W. Hulver,
• George A. Bray,
• and Steven R. Smith

A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

• Simon W. Coppack,
• David L. Chinkes,
• John M. Miles,
• Bruce W. Patterson,
• and Samuel Klein

A Multicompartmental Model of In Vivo Adipose Tissue Glycerol Kinetics and Capillary Permeability in Lean and Obese Humans

• Rita Basu,
• Visvanathan Chandramouli,
• Betty Dicke,
• Bernard Landau,
• and Robert Rizza

Obesity and Type 2 Diabetes Impair Insulin-Induced Suppression of Glycogenolysis as Well as Gluconeogenesis

• Victoria A. Payne,
• Catherine Arden,
• Chaodong Wu,
• Alex J. Lange,
• and Loranne Agius

Dual Role of Phosphofructokinase-2/Fructose Bisphosphatase-2 in Regulating the Compartmentation and Expression of Glucokinase in Hepatocytes

• Kazuhito Fukui,
• Tsutomu Wada,
• Syota Kagawa,
• Kiyofumi Nagira,
• Mariko Ikubo,
• Hajime Ishihara,
• Masashi Kobayashi,
• and Toshiyasu Sasaoka

Impact of the Liver-Specific Expression of SHIP2 (SH2-Containing Inositol 5′-Phosphatase 2) on Insulin Signaling and Glucose Metabolism in Mice

• Jessica C. Hogan and
• Jacqueline M. Stephens

The Regulation of Fatty Acid Synthase by STAT5A

• Yanqing Zhu,
• Marta Casado,
• Sophie Vaulont,
• and Kumar Sharma

Role of Upstream Stimulatory Factors in Regulation of Renal Transforming Growth Factor-β1

• Lucy F. Faulconbridge,
• Harvey J. Grill,
• and Joel M. Kaplan

Distinct Forebrain and Caudal Brainstem Contributions to the Neuropeptide Y Mediation of Ghrelin Hyperphagia

• Edward D. Javor,
• Elaine K. Cochran,
• Carla Musso,
• Janice Ryan Young,
• Alex M. DePaoli,
• and Phillip Gorden

Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy

• Daniela Dietze-Schroeder,
• Henrike Sell,
• Mathias Uhlig,
• Marlis Koenen,
• and Jürgen Eckel

Autocrine Action of Adiponectin on Human Fat Cells Prevents the Release of Insulin Resistance-Inducing Factors

• Kamal Rahmouni,
• Donald A. Morgan,
• Gina M. Morgan,
• Allyn L. Mark,
• and William G. Haynes

Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension

• Daniel J. Moore,
• Hooman Noorchashm,
• Tina H. Lin,
• Siri A. Greeley,
• and Ali Naji

NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity

• Yukiko Kagohashi,
• Jun Udagawa,
• Norio Abiru,
• Masakazu Kobayashi,
• Kenji Moriyama,
• and Hiroki Otani

Maternal Factors in a Model of Type 1 Diabetes Differentially Affect the Development of Insulitis and Overt Diabetes in Offspring

• F. Susan Wong,
• Wei Du,
• Ian J. Thomas,
• and Li Wen

The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 Mice

• Anne Jörns,
• Armin Günther,
• Hans-Jürgen Hedrich,
• Dirk Wedekind,
• Markus Tiedge,
• and Sigurd Lenzen

Immune Cell Infiltration, Cytokine Expression, and β-Cell Apoptosis During the Development of Type 1 Diabetes in the Spontaneously Diabetic LEW.1AR1/Ztm-iddm Rat

• Yousra Hassainya,
• Francisco Garcia-Pons,
• Roland Kratzer,
• Vivian Lindo,
• Fiona Greer,
• François A. Lemonnier,
• Gabriele Niedermann,
• and Peter M. van Endert

Identification of Naturally Processed HLA-A2—Restricted Proinsulin Epitopes by Reverse Immunology

• Edmond A. Ryan,
• Breay W. Paty,
• Peter A. Senior,
• David Bigam,
• Eman Alfadhli,
• Norman M. Kneteman,
• Jonathan R.T. Lakey,
• and A.M. James Shapiro

Five-Year Follow-Up After Clinical Islet Transplantation

• Michael J. Riedel and
• Peter E. Light

Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate Wild-Type and Polymorphic β-Cell ATP-Sensitive K⁺ Channels

• Rennian Wang,
• Jinming Li,
• Kristina Lyte,
• Nina K. Yashpal,
• Fraser Fellows,
• and Cynthia G. Goodyer

Role for β1 Integrin and Its Associated α3, α5, and α6 Subunits in Development of the Human Fetal Pancreas

• Jennifer Roccisana,
• Vasumathi Reddy,
• Rupangi C. Vasavada,
• Jose A. Gonzalez-Pertusa,
• Mark A. Magnuson,
• and Adolfo Garcia-Ocaña

Targeted Inactivation of Hepatocyte Growth Factor Receptor c-met in β-Cells Leads to Defective Insulin Secretion and GLUT-2 Downregulation Without Alteration of β-Cell Mass

• Kausar N. Samli,
• Michael J. McGuire,
• Christopher B. Newgard,
• Stephen Albert Johnston,
• and Kathlynn C. Brown

Peptide-Mediated Targeting of the Islets of Langerhans

• Tharun B. Mysore,
• Trixie A. Shinkel,
• James Collins,
• Evelyn J. Salvaris,
• Nella Fisicaro,
• Lisa J. Murray-Segal,
• Lucinda E.A. Johnson,
• Diana A. Lepore,
• Stacey N. Walters,
• Rebecca Stokes,
• Abhilash P. Chandra,
• Philip J. O’Connell,
• Anthony J.F. d’Apice,
• and Peter J. Cowan

Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function

• Johan F. Paulsson and
• Gunilla T. Westermark

Aberrant Processing of Human Proislet Amyloid Polypeptide Results in Increased Amyloid Formation

• Albert Salehi,
• Saleem S. Qader,
• Eva Grapengiesser,
• and Bo Hellman

Inhibition of Purinoceptors Amplifies Glucose-Stimulated Insulin Release With Removal of its Pulsatility

• Rosita Ivarsson,
• Roel Quintens,
• Sandra Dejonghe,
• Katsura Tsukamoto,
• Peter in ’t Veld,
• Erik Renström,
• and Frans C. Schuit

Redox Control of Exocytosis: Regulatory Role of NADPH, Thioredoxin, and Glutaredoxin

• Jiang Chen,
• Michael Kasper,
• Tobias Heck,
• Katsumi Nakagawa,
• Per M. Humpert,
• Ling Bai,
• Gang Wu,
• Youming Zhang,
• Thomas Luther,
• Martin Andrassy,
• Stephan Schiekofer,
• Andreas Hamann,
• Michael Morcos,
• Baoshen Chen,
• David M. Stern,
• Peter P. Nawroth,
• and Angelika Bierhaus

Tissue Factor as a Link Between Wounding and Tissue Repair

• Tong Lu,
• Xiao-Li Wang,
• Tongrong He,
• Wei Zhou,
• Terry L. Kaduce,
• Zvonimir S. Katusic,
• Arthur A. Spector,
• and Hon-Chi Lee

Impaired Arachidonic Acid–Mediated Activation of Large-Conductance Ca²⁺-Activated K⁺ Channels in Coronary Arterial Smooth Muscle Cells in Zucker Diabetic Fatty Rats

• Julia M. Steinke,
• Alan R. Sinaiko,
• Michael S. Kramer,
• Samy Suissa,
• Blanche M. Chavers,
• and Michael Mauer

The Early Natural History of Nephropathy in Type 1 Diabetes: III. Predictors of 5-Year Urinary Albumin Excretion Rate Patterns in Initially Normoalbuminuric Patients

• Justin B. Maxhimer,
• Michael Somenek,
• Geetha Rao,
• Catherine E. Pesce,
• David Baldwin, Jr.,
• Paolo Gattuso,
• Melvin M. Schwartz,
• Edmund J. Lewis,
• Richard A. Prinz,
• and Xiulong Xu

Heparanase-1 Gene Expression and Regulation by High Glucose in Renal Epithelial Cells: A Potential Role in the Pathogenesis of Proteinuria in Diabetic Patients

• Dominique Detaille,
• Bruno Guigas,
• Christiane Chauvin,
• Cécile Batandier,
• Eric Fontaine,
• Nicolas Wiernsperger,
• and Xavier Leverve

Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process

The Effect of Ruboxistaurin on Visual Loss in Patients With Moderately Severe to Very Severe Nonproliferative Diabetic Retinopathy: Initial Results of the Protein Kinase C β Inhibitor Diabetic Retinopathy Study (PKC-DRS) Multicenter Randomized Clinical Trial

• Marisa Passarelli,
• Chongren Tang,
• Thomas O. McDonald,
• Kevin D. O’Brien,
• Ross G. Gerrity,
• Jay W. Heinecke,
• and John F. Oram

Advanced Glycation End Product Precursors Impair ABCA1-Dependent Cholesterol Removal From Cells

• Frank Pistrosch,
• Kay Herbrig,
• Beate Kindel,
• Jens Passauer,
• Sabine Fischer,
• and Peter Gross

Rosiglitazone Improves Glomerular Hyperfiltration, Renal Endothelial Dysfunction, and Microalbuminuria of Incipient Diabetic Nephropathy in Patients

• Juris J. Meier,
• Guido Kemmeries,
• Jens J. Holst,
• and Michael A. Nauck

Erythromycin Antagonizes the Deceleration of Gastric Emptying by Glucagon-Like Peptide 1 and Unmasks Its Insulinotropic Effect in Healthy Subjects

• Anees Ahmad Banday,
• Aditi Marwaha,
• Lakshmi S. Tallam,
• and Mustafa F. Lokhandwala

Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats

• Ling Li,
• Jean-Claude Mamputu,
• Nicolas Wiernsperger,
• and Geneviève Renier

Signaling Pathways Involved in Human Vascular Smooth Muscle Cell Proliferation and Matrix Metalloproteinase-2 Expression Induced by Leptin: Inhibitory Effect of Metformin

• Rebecca L. Hull,
• Zhen-Ping Shen,
• Melissah R. Watts,
• Keiichi Kodama,
• Darcy B. Carr,
• Kristina M. Utzschneider,
• Sakeneh Zraika,
• Feng Wang,
• and Steven E. Kahn

Long-Term Treatment With Rosiglitazone and Metformin Reduces the Extent of, but Does Not Prevent, Islet Amyloid Deposition in Mice Expressing the Gene for Human Islet Amyloid Polypeptide

• Coleen M. Damcott,
• Sandra H. Ott,
• Toni I. Pollin,
• Laurie J. Reinhart,
• Jian Wang,
• Jeffrey R. O’Connell,
• Braxton D. Mitchell,
• and Alan R. Shuldiner

Genetic Variation in Adiponectin Receptor 1 and Adiponectin Receptor 2 Is Associated With Type 2 Diabetes in the Old Order Amish

• Margarita Teran-Garcia,
• Nicola Santoro,
• Tuomo Rankinen,
• Jean Bergeron,
• Treva Rice,
• Arthur S. Leon,
• D.C. Rao,
• James S. Skinner,
• Richard N. Bergman,
• Jean-Pierre Després,
• and Claude Bouchard

Hepatic Lipase Gene Variant −514C>T Is Associated With Lipoprotein and Insulin Sensitivity Response to Regular Exercise: The HERITAGE Family Study

• Olli Laukkanen,
• Jaana Lindström,
• Johan Eriksson,
• Timo T. Valle,
• Helena Hämäläinen,
• Pirjo Ilanne-Parikka,
• Sirkka Keinänen-Kiukaanniemi,
• Jaakko Tuomilehto,
• Matti Uusitupa,
• and Markku Laakso

Polymorphisms in the SLC2A2 (GLUT2) Gene Are Associated With the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes : The Finnish Diabetes Prevention Study

• Signe S. Torekov,
• Lesli H. Larsen,
• Charlotte Glümer,
• Knut Borch-Johnsen,
• Torben Jørgensen,
• Jens J. Holst,
• Ole D. Madsen,
• Torben Hansen,
• and Oluf Pedersen

Evidence of an Association Between the Arg72 Allele of the Peptide YY and Increased Risk of Type 2 Diabetes

• Franz M. Matschinsky

Retraction