Table of Contents

• Anthony P. Coll,
• Benjamin G. Challis,
• Miguel López,
• Sarah Piper,
• Giles S.H. Yeo,
• and Stephen O’Rahilly

Proopiomelanocortin-Deficient Mice Are Hypersensitive to the Adverse Metabolic Effects of Glucocorticoids

• Raffaella Cancello,
• Corneliu Henegar,
• Nathalie Viguerie,
• Soraya Taleb,
• Christine Poitou,
• Christine Rouault,
• Muriel Coupaye,
• Veronique Pelloux,
• Danielle Hugol,
• Jean-Luc Bouillot,
• Anne Bouloumié,
• Giorgio Barbatelli,
• Saverio Cinti,
• Per-Arne Svensson,
• Gregory S. Barsh,
• Jean-Daniel Zucker,
• Arnaud Basdevant,
• Dominique Langin,
• and Karine Clément

Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss

• Stefania Camastra,
• Melania Manco,
• Andrea Mari,
• Simona Baldi,
• Amalia Gastaldelli,
• Aldo V. Greco,
• Gertrude Mingrone,
• and Ele Ferrannini

β-Cell Function in Morbidly Obese Subjects During Free Living: Long-Term Effects of Weight Loss

• Katie Wynne,
• Adrian J. Park,
• Caroline J. Small,
• Michael Patterson,
• Sandra M. Ellis,
• Kevin G. Murphy,
• Alison M. Wren,
• Gary S. Frost,
• Karim Meeran,
• Mohammad A. Ghatei,
• and Stephen R. Bloom

Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects: A Double-Blind, Randomized, Controlled Trial

• Daniel Nyqvist,
• Martin Köhler,
• Helene Wahlstedt,
• and Per-Olof Berggren

Donor Islet Endothelial Cells Participate in Formation of Functional Vessels Within Pancreatic Islet Grafts

• Conny A. Gysemans,
• Laurence Ladrière,
• Hanne Callewaert,
• Joanne Rasschaert,
• Daisy Flamez,
• David E. Levy,
• Patrick Matthys,
• Décio L. Eizirik,
• and Chantal Mathieu

Disruption of the γ-Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of β-cells

• Thomas L. Jetton,
• James Lausier,
• Kyla LaRock,
• Winifred E. Trotman,
• Brooke Larmie,
• Aida Habibovic,
• Mina Peshavaria,
• and Jack L. Leahy

Mechanisms of Compensatory β-Cell Growth in Insulin-Resistant Rats: Roles of Akt Kinase

• Gina B. Di Gregorio,
• Aiwei Yao-Borengasser,
• Neda Rasouli,
• Vijayalakshmi Varma,
• Tong Lu,
• Leslie M. Miles,
• Gouri Ranganathan,
• Charlotte A. Peterson,
• Robert E. McGehee,
• and Philip A. Kern

Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues: Association With Cytokine Expression, Insulin Resistance, and Reduction by Pioglitazone

• Oana Sandu,
• Keying Song,
• Weijing Cai,
• Feng Zheng,
• Jaime Uribarri,
• and Helen Vlassara

Insulin Resistance and Type 2 Diabetes in High-Fat–Fed Mice Are Linked to High Glycotoxin Intake

Role of Insulin Secretion and Sensitivity in the Evolution of Type 2 Diabetes in the Diabetes Prevention Program: Effects of Lifestyle Intervention and Metformin

• Bart Janssen,
• Daniela Hohenadel,
• Paul Brinkkoetter,
• Verena Peters,
• Nina Rind,
• Christine Fischer,
• Ivan Rychlik,
• Marie Cerna,
• Marianna Romzova,
• Emile de Heer,
• Hans Baelde,
• Stephan J.L. Bakker,
• Mahmoud Zirie,
• Eric Rondeau,
• Peter Mathieson,
• Moin A. Saleem,
• Jochen Meyer,
• Hannes Köppel,
• Sibylle Sauerhoefer,
• Claus R. Bartram,
• Peter Nawroth,
• Hans-Peter Hammes,
• Benito A. Yard,
• Johannes Zschocke,
• and Fokko J. van der Woude

Carnosine as a Protective Factor in Diabetic Nephropathy: Association With a Leucine Repeat of the Carnosinase Gene CNDP1

• Zhuowei Wang,
• Tao Jiang,
• Jinping Li,
• Gregory Proctor,
• James L. McManaman,
• Scott Lucia,
• Streamson Chua,
• and Moshe Levi

Regulation of Renal Lipid Metabolism, Lipid Accumulation, and Glomerulosclerosis in FVB^db/db Mice With Type 2 Diabetes

• Elena B. Okon,
• Ada W.Y. Chung,
• Pooja Rauniyar,
• Eugenia Padilla,
• Teresa Tejerina,
• Bruce M. McManus,
• Honglin Luo,
• and Cornelis van Breemen

Compromised Arterial Function in Human Type 2 Diabetic Patients

• Pilar Justo,
• Ana Belén Sanz,
• Jesús Egido,
• and Alberto Ortiz

3,4-Dideoxyglucosone-3-ene Induces Apoptosis in Renal Tubular Epithelial Cells

• Dominick J. Angiolillo,
• Antonio Fernandez-Ortiz,
• Esther Bernardo,
• Celia Ramírez,
• Manel Sabaté,
• Pilar Jimenez-Quevedo,
• Rosana Hernández,
• Raul Moreno,
• Javier Escaned,
• Fernando Alfonso,
• Camino Bañuelos,
• Marco A. Costa,
• Theodore A. Bass,
• and Carlos Macaya

Platelet Function Profiles in Patients With Type 2 Diabetes and Coronary Artery Disease on Combined Aspirin and Clopidogrel Treatment

• Wendy Winckler,
• Noël P. Burtt,
• Johan Holmkvist,
• Camilla Cervin,
• Paul I.W. de Bakker,
• Maria Sun,
• Peter Almgren,
• Tiinamaija Tuomi,
• Daniel Gaudet,
• Thomas J. Hudson,
• Kristin G. Ardlie,
• Mark J. Daly,
• Joel N. Hirschhorn,
• David Altshuler,
• and Leif Groop

Association of Common Variation in the HNF1α Gene Region With Risk of Type 2 Diabetes

• J. Darcy MacLellan,
• Martin F. Gerrits,
• Adrienne Gowing,
• Peter J.S. Smith,
• Michael B. Wheeler,
• and Mary-Ellen Harper

Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells

• Gautam K. Bandyopadhyay,
• Joseph G. Yu,
• Jachelle Ofrecio,
• and Jerold M. Olefsky

Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle

• Andrew Tsang,
• Derek J. Hausenloy,
• Mihaela M. Mocanu,
• Richard D. Carr,
• and Derek M. Yellon

Preconditioning the Diabetic Heart: The Importance of Akt Phosphorylation

• Tomohiro Tanaka,
• Shuji Hidaka,
• Hiroaki Masuzaki,
• Shintaro Yasue,
• Yasuhiko Minokoshi,
• Ken Ebihara,
• Hideki Chusho,
• Yoshihiro Ogawa,
• Taro Toyoda,
• Kenji Sato,
• Fumiko Miyanaga,
• Muneya Fujimoto,
• Tsutomu Tomita,
• Toru Kusakabe,
• Nozomi Kobayashi,
• Hideki Tanioka,
• Tatsuya Hayashi,
• Kiminori Hosoda,
• Hironobu Yoshimatsu,
• Toshiie Sakata,
• and Kazuwa Nakao

Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation Parallels Metabolic Phenotype in Leptin Transgenic Mice Under Dietary Modification

• Jérémy Fauconnier,
• Johanna T. Lanner,
• Shi-Jin Zhang,
• Pasi Tavi,
• Joseph D. Bruton,
• Abram Katz,
• and Håkan Westerblad

Insulin and Inositol 1,4,5-Trisphosphate Trigger Abnormal Cytosolic Ca²⁺ Transients and Reveal Mitochondrial Ca²⁺ Handling Defects in Cardiomyocytes of ob/ob Mice

• Victor A. Gault,
• Nigel Irwin,
• Brian D. Green,
• Jane T. McCluskey,
• Brett Greer,
• Clifford J. Bailey,
• Patrick Harriott,
• Finbarr P.M. O’Harte,
• and Peter R. Flatt

Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro³)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes

• Sun H. Kim,
• Fahim Abbasi,
• James W. Chu,
• Tracey L. McLaughlin,
• Cindy Lamendola,
• Kenneth S. Polonsky,
• and Gerald M. Reaven

Rosiglitazone Reduces Glucose-Stimulated Insulin Secretion Rate and Increases Insulin Clearance in Nondiabetic, Insulin-Resistant Individuals

• David J. Baker,
• James A. Timmons,
• and Paul L. Greenhaff

Glycogen Phosphorylase Inhibition in Type 2 Diabetes Therapy: A Systematic Evaluation of Metabolic and Functional Effects in Rat Skeletal Muscle

• Bart Staels and
• Jean-Charles Fruchart

Therapeutic Roles of Peroxisome Proliferator–Activated Receptor Agonists

• Angela G. Stoyanovitch,
• Marlie A. Johnson,
• Donald K. Clifton,
• Robert A. Steiner,
• and Gregory S. Fraley

Galanin-Like Peptide Rescues Reproductive Function in the Diabetic Rat

• Afshan Siddiq,
• Frederic Lepretre,
• Serge Hercberg,
• Philippe Froguel,
• and Fernando Gibson

A Synonymous Coding Polymorphism in the α2-Heremans-Schmid Glycoprotein Gene Is Associated With Type 2 Diabetes in French Caucasians

• Andrea K. Steck,
• Teodorica L. Bugawan,
• Ana Maria Valdes,
• Lisa M. Emery,
• Alan Blair,
• Jill M. Norris,
• Maria J. Redondo,
• Sunanda R. Babu,
• Henry A. Erlich,
• George S. Eisenbarth,
• and Marian J. Rewers

Association of Non-HLA Genes With Type 1 Diabetes Autoimmunity

• Michael N. Weedon,
• Katharine R. Owen,
• Beverley Shields,
• Graham Hitman,
• Mark Walker,
• Mark I. McCarthy,
• Andrew T. Hattersley,
• and Timothy M. Frayling

A Large-Scale Association Analysis of Common Variation of the HNF1α Gene With Type 2 Diabetes in the U.K. Caucasian Population

• Michelle Baker,
• Nicole Gaukrodger,
• Bongani M. Mayosi,
• Helen Imrie,
• Martin Farrall,
• Hugh Watkins,
• John M.C. Connell,
• Peter J. Avery,
• and Bernard Keavney

Association Between Common Polymorphisms of the Proopiomelanocortin Gene and Body Fat Distribution: A Family Study

• R. Paul Robertson

Paul Eston Lacy, MD, PhD

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