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Table of Contents

September 2005; 54 (9)

Perspectives in Diabetes

    • Andrew T. Hattersley and
    • Frances M. Ashcroft

    Activating Mutations in Kir6.2 and Neonatal Diabetes: New Clinical Syndromes, New Scientific Insights, and New Therapy

    Diabetes September 2005 54:2503-2513; doi:10.2337/diabetes.54.9.2503

Signal Transduction

    • So-Young Park,
    • You-Ree Cho,
    • Brian N. Finck,
    • Hyo-Jeong Kim,
    • Takamasa Higashimori,
    • Eun-Gyoung Hong,
    • Mi-Kyung Lee,
    • Cheryl Danton,
    • Swati Deshmukh,
    • Gary W. Cline,
    • Julie J. Wu,
    • Anton M. Bennett,
    • Beverly Rothermel,
    • April Kalinowski,
    • Kerry S. Russell,
    • Young-Bum Kim,
    • Daniel P. Kelly,
    • and Jason K. Kim

    Cardiac-Specific Overexpression of Peroxisome Proliferator–Activated Receptor-α Causes Insulin Resistance in Heart and Liver

    Diabetes September 2005 54:2514-2524; doi:10.2337/diabetes.54.9.2514
    • Mark E. Cleasby,
    • Jonathan R. Davey,
    • Tracie A. Reinten,
    • Michael W. Graham,
    • David E. James,
    • Edward W. Kraegen,
    • and Gregory J. Cooney

    Acute Bidirectional Manipulation of Muscle Glucose Uptake by In Vivo Electrotransfer of Constructs Targeting Glucose Transporter Genes

    Diabetes September 2005 54:2702-2711; doi:10.2337/diabetes.54.9.2702

Immunology and Transplantation

    • Chul-Ho Lee,
    • Peter C. Reifsnyder,
    • Jürgen K. Naggert,
    • Clive Wasserfall,
    • Mark A. Atkinson,
    • Jing Chen,
    • and Edward H. Leiter

    Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: I. Pathophysiological Analysis

    Diabetes September 2005 54:2525-2532; doi:10.2337/diabetes.54.9.2525
    • Annette Plesner,
    • Peter Liston,
    • Rusung Tan,
    • Robert G. Korneluk,
    • and C. Bruce Verchere

    The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts

    Diabetes September 2005 54:2533-2540; doi:10.2337/diabetes.54.9.2533
    • Juliet A. Emamaullee,
    • Ray V. Rajotte,
    • Peter Liston,
    • Robert G. Korneluk,
    • Jonathan R.T. Lakey,
    • A.M. James Shapiro,
    • and John F. Elliott

    XIAP Overexpression in Human Islets Prevents Early Posttransplant Apoptosis and Reduces the Islet Mass Needed to Treat Diabetes

    Diabetes September 2005 54:2541-2548; doi:10.2337/diabetes.54.9.2541
    • Devasenan Devendra,
    • Jean Jasinski,
    • Evie Melanitou,
    • Maki Nakayama,
    • Marcella Li,
    • Brooke Hensley,
    • Johanna Paronen,
    • Hiroaki Moriyama,
    • Dongmei Miao,
    • George S. Eisenbarth,
    • and Edwin Liu

    Interferon-α as a Mediator of Polyinosinic:Polycytidylic Acid–Induced Type 1 Diabetes

    Diabetes September 2005 54:2549-2556; doi:10.2337/diabetes.54.9.2549
    • John P. Mordes,
    • Dennis L. Guberski,
    • Jean H. Leif,
    • Bruce A. Woda,
    • Joan F. Flanagan,
    • Dale L. Greiner,
    • Edward H. Kislauskis,
    • and Rebecca S. Tirabassi

    LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environmental Perturbation

    Diabetes September 2005 54:2727-2733; doi:10.2337/diabetes.54.9.2727

Islet Studies

    • Monica Teta,
    • Simon Y. Long,
    • Lynn M. Wartschow,
    • Matthew M. Rankin,
    • and Jake A. Kushner

    Very Slow Turnover of β-Cells in Aged Adult Mice

    Diabetes September 2005 54:2557-2567; doi:10.2337/diabetes.54.9.2557
    • Michal Zalzman,
    • Leeat Anker-Kitai,
    • and Shimon Efrat

    Differentiation of Human Liver-Derived, Insulin-Producing Cells Toward the β-Cell Phenotype

    Diabetes September 2005 54:2568-2575; doi:10.2337/diabetes.54.9.2568
    • Rajakrishnan Veluthakal,
    • Irina Chvyrkova,
    • Marie Tannous,
    • Phillip McDonald,
    • Rajesh Amin,
    • Timothy Hadden,
    • Debbie C. Thurmond,
    • Michael J. Quon,
    • and Anjaneyulu Kowluru

    Essential Role for Membrane Lipid Rafts in Interleukin-1β−Induced Nitric Oxide Release From Insulin-Secreting Cells: Potential Regulation by Caveolin-1+

    Diabetes September 2005 54:2576-2585; doi:10.2337/diabetes.54.9.2576
    • Andrew M. Holland,
    • L. Jorge Góñez,
    • Gaetano Naselli,
    • Raymond J. MacDonald,
    • and Leonard C. Harrison

    Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of β-Cells in the Adult Pancreas

    Diabetes September 2005 54:2586-2595; doi:10.2337/diabetes.54.9.2586
    • Wilma L. Suarez-Pinzon,
    • Yanhua Yan,
    • Robert Power,
    • Stephen J. Brand,
    • and Alex Rabinovitch

    Combination Therapy With Epidermal Growth Factor and Gastrin Increases β-Cell Mass and Reverses Hyperglycemia in Diabetic NOD Mice

    Diabetes September 2005 54:2596-2601; doi:10.2337/diabetes.54.9.2596
    • Won-Ho Kim,
    • June Woo Lee,
    • Young Ho Suh,
    • Shin Hee Hong,
    • Joo Sun Choi,
    • Joo Hyun Lim,
    • Ji Hyun Song,
    • Bin Gao,
    • and Myeong Ho Jung

    Exposure to Chronic High Glucose Induces β-Cell Apoptosis Through Decreased Interaction of Glucokinase With Mitochondria: Downregulation of Glucokinase in Pancreatic β-Cells

    Diabetes September 2005 54:2602-2611; doi:10.2337/diabetes.54.9.2602
    • Yun-Ping Zhou,
    • Azadeh Madjidi,
    • Maria E. Wilson,
    • David A. Nothhelfer,
    • John H. Johnson,
    • John F. Palma,
    • Anthony Schweitzer,
    • Charles Burant,
    • John E. Blume,
    • and Jeffrey D. Johnson

    Matrix Metalloproteinases Contribute to Insulin Insufficiency in Zucker Diabetic Fatty Rats

    Diabetes September 2005 54:2612-2619; doi:10.2337/diabetes.54.9.2612
    • Edwin P. Kwan and
    • Herbert Y. Gaisano

    Glucagon-Like Peptide 1 Regulates Sequential and Compound Exocytosis in Pancreatic Islet β-Cells

    Diabetes September 2005 54:2734-2743; doi:10.2337/diabetes.54.9.2734
    • Patrick P.L. Lam,
    • Yuk-Man Leung,
    • Laura Sheu,
    • James Ellis,
    • Robert G. Tsushima,
    • Lucy R. Osborne,
    • and Herbert Y. Gaisano

    Transgenic Mouse Overexpressing Syntaxin-1A as a Diabetes Model

    Diabetes September 2005 54:2744-2754; doi:10.2337/diabetes.54.9.2744
    • Cecilie Kjørholt,
    • Mia C. Åkerfeldt,
    • Trevor J. Biden,
    • and D. Ross Laybutt

    Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of β-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes

    Diabetes September 2005 54:2755-2763; doi:10.2337/diabetes.54.9.2755

Pathophysiology

    • Caroline Kampf,
    • Birgitta Bodin,
    • Örjan Källskog,
    • Carina Carlsson,
    • and Leif Jansson

    Marked Increase in White Adipose Tissue Blood Perfusion in the Type 2 Diabetic GK Rat

    Diabetes September 2005 54:2620-2627; doi:10.2337/diabetes.54.9.2620
    • April J. Emerick,
    • Michael P. Richards,
    • Gwendolyn L. Kartje,
    • Edward J. Neafsey,
    • and Evan B. Stubbs, Jr.

    Experimental Diabetes Attenuates Cerebral Cortical−Evoked Forelimb Motor Responses

    Diabetes September 2005 54:2764-2771; doi:10.2337/diabetes.54.9.2764
    • Nikki C. Bush,
    • Betty E. Darnell,
    • Robert A. Oster,
    • Michael I. Goran,
    • and Barbara A. Gower

    Adiponectin Is Lower Among African Americans and Is Independently Related to Insulin Sensitivity in Children and Adolescents

    Diabetes September 2005 54:2772-2778; doi:10.2337/diabetes.54.9.2772
    • Christine Cipolletta,
    • Kathryn E. Ryan,
    • Elinor V. Hanna,
    • and Elisabeth R. Trimble

    Activation of Peripheral Blood CD14+ Monocytes Occurs in Diabetes

    Diabetes September 2005 54:2779-2786; doi:10.2337/diabetes.54.9.2779

Complications

    • Zhonghua Qi,
    • Hiroki Fujita,
    • Jianping Jin,
    • Linda S. Davis,
    • Yihan Wang,
    • Agnes B. Fogo,
    • and Matthew D. Breyer

    Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy

    Diabetes September 2005 54:2628-2637; doi:10.2337/diabetes.54.9.2628
    • Alex K. Harris,
    • Jim R. Hutchinson,
    • Kamakshi Sachidanandam,
    • Maribeth H. Johnson,
    • Anne M. Dorrance,
    • David W. Stepp,
    • Susan C. Fagan,
    • and Adviye Ergul

    Type 2 Diabetes Causes Remodeling of Cerebrovasculature via Differential Regulation of Matrix Metalloproteinases and Collagen Synthesis: Role of Endothelin-1

    Diabetes September 2005 54:2638-2644; doi:10.2337/diabetes.54.9.2638

Genetics

    • Joseph C. Koster,
    • Maria S. Remedi,
    • Crystal Dao,
    • and Colin G. Nichols

    ATP and Sulfonylurea Sensitivity of Mutant ATP-Sensitive K+ Channels in Neonatal Diabetes: Implications for Pharmacogenomic Therapy

    Diabetes September 2005 54:2645-2654; doi:10.2337/diabetes.54.9.2645
    • Kelly J. Hunt,
    • Donna M. Lehman,
    • Rector Arya,
    • Sharon Fowler,
    • Robin J. Leach,
    • Harald H.H. Göring,
    • Laura Almasy,
    • John Blangero,
    • Tom D. Dyer,
    • Ravindranath Duggirala,
    • and Michael P. Stern

    Genome-Wide Linkage Analyses of Type 2 Diabetes in Mexican Americans: The San Antonio Family Diabetes/Gallbladder Study

    Diabetes September 2005 54:2655-2662; doi:10.2337/diabetes.54.9.2655
    • Paul W. Franks,
    • Jian’an Luan,
    • Inês Barroso,
    • Søren Brage,
    • Jose Luis Gonzalez Sanchez,
    • Ulf Ekelund,
    • Manuel Serrano Ríos,
    • Alan J. Schafer,
    • Stephen O’Rahilly,
    • and Nicholas J. Wareham

    Variation in the eNOS Gene Modifies the Association Between Total Energy Expenditure and Glucose Intolerance

    Diabetes September 2005 54:2795-2801; doi:10.2337/diabetes.54.9.2795

Brief Genetics Reports

    • Ningping Feng,
    • Sharla F. Young,
    • Greti Aguilera,
    • Elena Puricelli,
    • Diane C. Adler-Wailes,
    • Nancy G. Sebring,
    • and Jack A. Yanovski

    Co-occurrence of Two Partially Inactivating Polymorphisms of MC3R Is Associated With Pediatric-Onset Obesity

    Diabetes September 2005 54:2663-2667; doi:10.2337/diabetes.54.9.2663
    • Mahmoud Suleiman,
    • Doron Aronson,
    • Rabea Asleh,
    • Michael R. Kapeliovich,
    • Ariel Roguin,
    • Simcha R. Meisel,
    • Michael Shochat,
    • Abeer Sulieman,
    • Shimon A. Reisner,
    • Walter Markiewicz,
    • Haim Hammerman,
    • Rachel Lotan,
    • Nina S. Levy,
    • and Andrew P. Levy

    Haptoglobin Polymorphism Predicts 30-Day Mortality and Heart Failure in Patients With Diabetes and Acute Myocardial Infarction

    Diabetes September 2005 54:2802-2806; doi:10.2337/diabetes.54.9.2802
    • Sabrina Prudente,
    • Marta Letizia Hribal,
    • Elisabetta Flex,
    • Federica Turchi,
    • Eleonora Morini,
    • Salvatore De Cosmo,
    • Simonetta Bacci,
    • Vittorio Tassi,
    • Marina Cardellini,
    • Renato Lauro,
    • Giorgio Sesti,
    • Bruno Dallapiccola,
    • and Vincenzo Trischitta

    The Functional Q84R Polymorphism of Mammalian Tribbles Homolog TRB3 Is Associated With Insulin Resistance and Related Cardiovascular Risk in Caucasians From Italy

    Diabetes September 2005 54:2807-2811; doi:10.2337/diabetes.54.9.2807
    • Manjinder S. Sandhu,
    • Barbara Heude,
    • Elizabeth H. Young,
    • Robert Luben,
    • Jian’an Luan,
    • Kay-Tee Khaw,
    • John Todd,
    • and Nicholas J. Wareham

    INS VNTR Class Genotype and Indexes of Body Size and Obesity : Population-Based Studies of 7,999 Middle-Aged Men and Women

    Diabetes September 2005 54:2812-2815; doi:10.2337/diabetes.54.9.2812
    • Robert Hermann,
    • Jussi Mantere,
    • Kati Lipponen,
    • Riitta Veijola,
    • Gyula Soltesz,
    • Timo Otonkoski,
    • Olli Simell,
    • Mikael Knip,
    • and Jorma Ilonen

    Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

    Diabetes September 2005 54:2816-2819; doi:10.2337/diabetes.54.9.2816
    • Jade E. Hollis-Moffatt,
    • Sarah M. Hook,
    • and Tony R. Merriman

    Colocalization of Mouse Autoimmune Diabetes Loci Idd21.1 and Idd21.2 With IDDM6 (Human) and Iddm3 (Rat)

    Diabetes September 2005 54:2820-2825; doi:10.2337/diabetes.54.9.2820

Metabolism

    • Brian R. Barrows,
    • Maureen T. Timlin,
    • and Elizabeth J. Parks

    Spillover of Dietary Fatty Acids and Use of Serum Nonesterified Fatty Acids for the Synthesis of VLDL-Triacylglycerol Under Two Different Feeding Regimens

    Diabetes September 2005 54:2668-2673; doi:10.2337/diabetes.54.9.2668
    • Frédéric Tremblay,
    • Michael Krebs,
    • Luce Dombrowski,
    • Attila Brehm,
    • Elisabeth Bernroider,
    • Erich Roth,
    • Peter Nowotny,
    • Werner Waldhäusl,
    • André Marette,
    • and Michael Roden

    Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability

    Diabetes September 2005 54:2674-2684; doi:10.2337/diabetes.54.9.2674
    • Daniel Bach,
    • Deborah Naon,
    • Sara Pich,
    • Francesc X. Soriano,
    • Nathalie Vega,
    • Jennifer Rieusset,
    • Martine Laville,
    • Christelle Guillet,
    • Yves Boirie,
    • Harriet Wallberg-Henriksson,
    • Melania Manco,
    • Menotti Calvani,
    • Marco Castagneto,
    • Manuel Palacín,
    • Geltrude Mingrone,
    • Juleen R. Zierath,
    • Hubert Vidal,
    • and Antonio Zorzano

    Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle : Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor α and Interleukin-6

    Diabetes September 2005 54:2685-2693; doi:10.2337/diabetes.54.9.2685
    • Maureen T. Timlin,
    • Brian R. Barrows,
    • and Elizabeth J. Parks

    Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men

    Diabetes September 2005 54:2694-2701; doi:10.2337/diabetes.54.9.2694

Obesity Studies

    • Thomas Bobbert,
    • Helmut Rochlitz,
    • Uta Wegewitz,
    • Suzan Akpulat,
    • Knut Mai,
    • Martin O. Weickert,
    • Matthias Möhlig,
    • Andreas F.H. Pfeiffer,
    • and Joachim Spranger

    Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction

    Diabetes September 2005 54:2712-2719; doi:10.2337/diabetes.54.9.2712
    • Kirsi A. Virtanen,
    • Patricia Iozzo,
    • Kirsti Hällsten,
    • Risto Huupponen,
    • Riitta Parkkola,
    • Tuula Janatuinen,
    • Fredrik Lönnqvist,
    • Tapio Viljanen,
    • Tapani Rönnemaa,
    • Peter Lönnroth,
    • Juhani Knuuti,
    • Ele Ferrannini,
    • and Pirjo Nuutila

    Increased Fat Mass Compensates for Insulin Resistance in Abdominal Obesity and Type 2 Diabetes: A Positron-Emitting Tomography Study

    Diabetes September 2005 54:2720-2726; doi:10.2337/diabetes.54.9.2720

Pharmacology & Therapeutics

    • Riikka Lautamäki,
    • K.E. Juhani Airaksinen,
    • Marko Seppänen,
    • Jyri Toikka,
    • Matti Luotolahti,
    • Elizabeth Ball,
    • Ronald Borra,
    • Risto Härkönen,
    • Patricia Iozzo,
    • Murray Stewart,
    • Juhani Knuuti,
    • and Pirjo Nuutila

    Rosiglitazone Improves Myocardial Glucose Uptake in Patients With Type 2 Diabetes and Coronary Artery Disease: A 16-Week Randomized, Double-Blind, Placebo-Controlled Study

    Diabetes September 2005 54:2787-2794; doi:10.2337/diabetes.54.9.2787

Erratum

  • Erratum

    Diabetes September 2005 54:2826; doi:10.2337/diabetes.54.9.2826
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This Issue

September 2005; 54 (9)
  1. Perspectives in Diabetes
  2. Signal Transduction
  3. Immunology and Transplantation
  4. Islet Studies
  5. Pathophysiology
  6. Complications
  7. Genetics
  8. Brief Genetics Reports
  9. Metabolism
  10. Obesity Studies
  11. Pharmacology & Therapeutics
  12. Erratum

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