INS VNTR Class Genotype and Indexes of Body Size and Obesity
Population-Based Studies of 7,999 Middle-Aged Men and Women
- Manjinder S. Sandhu12,
- Barbara Heude2,
- Elizabeth H. Young12,
- Robert Luben1,
- Jian’an Luan2,
- Kay-Tee Khaw1,
- John Todd3 and
- Nicholas J. Wareham2
- 1Department of Public Health & Primary Care, Institute of Public Health, University of Cambridge, Cambridge, U.K
- 2MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, U.K
- 3Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K
- Address correspondence and reprint requests to Dr. Manjinder S. Sandhu, Department of Public Health & Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway, Cambridge, CB1 8RN, U.K. E-mail: manj.sandhu{at}srl.cam.ac.uk
Abstract
The relevance of the insulin gene (INS) variable number tandem repeat (VNTR) polymorphism to indexes of body size and adult obesity is inconclusive. Given the equivocal reports on the association between the VNTR class genotype at the insulin gene locus and indexes of body size and obesity, we assessed these associations in a series of cohort studies based on 7,999 middle-aged men and women. We found no convincing evidence that INS VNTR class genotype was associated with indexes of body size and adult obesity. These data suggest that INS VNTR class is not an important determinant of size and body weight regulation in middle-aged men and women.
Footnotes
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- Accepted June 1, 2005.
- Received April 20, 2005.
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