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Glucose-induced β-cell apoptosis in cultured islets of diabetes-prone and -resistant Psammomys obesus and in normal rat islets. Islets were cultured for 9–10 days in 5.5, 11.1, and 33.3 mmol/l glucose. *P < 0.001 relative to islets at 5.5 mmol/l glucose. Adapted from Donath et al. (10).