Mechanisms of β-Cell Death in Type 2 Diabetes

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FIG. 2.
FIG. 2.

Hypothetical model illustrating the consequence of hyperglycemia on β-cell production of IL-1β in parallel with insulin secretion. The paracrine effect of IL-1β induces Fas engagement, which in the presence of FLIP leads to β-cell proliferation, differentiation, and increased function.

This Article

  1. Diabetes vol. 54 no. suppl 2 S108-S113