(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.
Hypothetical model illustrating the consequence of hyperglycemia on β-cell production of IL-1β in parallel with insulin secretion.
The paracrine effect of IL-1β induces Fas engagement, which in the presence of FLIP leads to β-cell proliferation, differentiation,
and increased function.