Mechanisms of β-Cell Death in Type 2 Diabetes

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FIG. 4.
FIG. 4.

Proposed model for mechanisms regulating β-cell mass in type 2 diabetes. Before onset of diabetes, insulin resistance may lead to transient postprandial hyperglycemic excursions. Other factors modulating β-cell mass may include dyslipidemia, leptin, and cytokines. Genetic predisposition to diabetes may include a predetermined amount of β-cell mass, as well as differences in the susceptibility to apoptotic signals and in the regenerative potential of the β-cell. Additionally, induction of local inflammatory mediators and cell death may activate the acquired immune system. Finally, drugs may protect or harm the β-cell. GLP1, glucagon-like peptide 1; IRS-2, insulin receptor substrate 2; TNFα, tumor necrosis factor-α.

This Article

  1. Diabetes vol. 54 no. suppl 2 S108-S113