Autoantibodies in Diabetes

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FIG. 2.
FIG. 2.

Illustration of isotype switching associated with disease susceptibility. We hypothesize that while the predominant GAD65Ab isotypes in the susceptible subject will be of IgG1 and IgG3, the majority of GAD65Abs in nonsusceptible subjects will be of the IgM class and disappear during follow-up. Only a small percentage will switch to IgG.

This Article

  1. Diabetes vol. 54 no. suppl 2 S52-S61