Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

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FIG. 1.
FIG. 1.

The transcription factor and gene networks putatively involved in the cytokine-promoted β-cell “decision” to undergo apoptosis. The transcription factors NF-κB and STAT-1 are the main regulators of the pathways triggered by IL-1β and IFN-γ, respectively. The figure is based on Refs. 1418. MHC-1, major histocompatibility complex 1.

This Article

  1. Diabetes vol. 54 no. suppl 2 S97-S107