The transcription factor and gene networks putatively involved in the cytokine-promoted β-cell “decision” to undergo apoptosis.
The transcription factors NF-κB and STAT-1 are the main regulators of the pathways triggered by IL-1β and IFN-γ, respectively.
The figure is based on Refs. 14–18. MHC-1, major histocompatibility complex 1.