Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

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FIG. 2.
FIG. 2.

Proposed model for the different pathways contributing to the execution of cytokine-induced β-cell apoptosis. Arrows indicate genes for which expression was modified by cytokines in a time course microarray analysis (15). β-Cell apoptosis is probably mediated by three main pathways—namely JNK, ER stress, and liberation of pro-apoptotic proteins from the mitochondria.

This Article

  1. Diabetes vol. 54 no. suppl 2 S97-S107