Table of Contents

Perspectives in Diabetes

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- Franz M. Matschinsky,
- Mark A. Magnuson,
- Dorothy Zelent,
- Tom L. Jetton,
- Nicolai Doliba,
- Yi Han,
- Rebecca Taub,
- and Joseph Grimsby
The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy
Diabetes January 2006 55:1-12; doi:10.2337/diabetes.55.01.06.db05-0926

New Methodology and Database

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- Timo Otonkoski,
- Kirsti Näntö-Salonen,
- Marko Seppänen,
- Riitta Veijola,
- Hanna Huopio,
- Khalid Hussain,
- Päivi Tapanainen,
- Olli Eskola,
- Riitta Parkkola,
- Klas Ekström,
- Yves Guiot,
- Jacques Rahier,
- Markku Laakso,
- Risto Rintala,
- Pirjo Nuutila,
- and Heikki Minn
Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [¹⁸F]-DOPA Positron Emission Tomography
Diabetes January 2006 55:13-18; doi:10.2337/diabetes.55.01.06.db05-1128

Obesity Studies

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- Amanda Sainsbury,
- Hugo T. Bergen,
- Dana Boey,
- Darja Bamming,
- Gregory J. Cooney,
- Shu Lin,
- Michelle Couzens,
- Nikolas Stroth,
- Nicola J. Lee,
- Diana Lindner,
- Nicolas Singewald,
- Tim Karl,
- Liesl Duffy,
- Ronaldo Enriquez,
- Katy Slack,
- Günther Sperk,
- and Herbert Herzog
Y2Y4 Receptor Double Knockout Protects Against Obesity Due to a High-Fat Diet or Y1 Receptor Deficiency in Mice
Diabetes January 2006 55:19-26; doi:10.2337/diabetes.55.01.06.db05-0472
Select this article
- Joachim Spranger,
- Sulekha Verma,
- Isabel Göhring,
- Thomas Bobbert,
- Joseph Seifert,
- Amy L. Sindler,
- Andreas Pfeiffer,
- Stanley M. Hileman,
- Matthias Tschöp,
- and William A. Banks
Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells
Diabetes January 2006 55:141-147; doi:10.2337/diabetes.55.01.06.db05-1077
Select this article
- Erin E. Kershaw,
- Jonathan K. Hamm,
- Linda A.W. Verhagen,
- Odile Peroni,
- Masa Katic,
- and Jeffrey S. Flier
Adipose Triglyceride Lipase: Function, Regulation by Insulin, and Comparison With Adiponutrin
Diabetes January 2006 55:148-157; doi:10.2337/diabetes.55.01.06.db05-0982

Immunology and Transplantation

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- Sulaiman A. Nanji,
- Wayne W. Hancock,
- Bin Luo,
- Colleen D. Schur,
- Rena L. Pawlick,
- Lin Fu Zhu,
- Colin C. Anderson,
- and A.M. James Shapiro
Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in the NOD Mouse
Diabetes January 2006 55:27-33; doi:10.2337/diabetes.55.01.06.db04-1154
Select this article
- Atsushi Toyofuku,
- Yohichi Yasunami,
- Kentaroh Nabeyama,
- Masahiko Nakano,
- Masayuki Satoh,
- Nobuhide Matsuoka,
- Junko Ono,
- Toshinori Nakayama,
- Masaru Taniguchi,
- Masao Tanaka,
- and Seiyo Ikeda
Natural Killer T-Cells Participate in Rejection of Islet Allografts in the Liver of Mice
Diabetes January 2006 55:34-39; doi:10.2337/diabetes.55.01.06.db05-0692
Select this article
- Manuela Battaglia,
- Angela Stabilini,
- Elena Draghici,
- Silvia Gregori,
- Cristina Mocchetti,
- Ezio Bonifacio,
- and Maria-Grazia Roncarolo
Rapamycin and Interleukin-10 Treatment Induces T Regulatory Type 1 Cells That Mediate Antigen-Specific Transplantation Tolerance
Diabetes January 2006 55:40-49; doi:10.2337/diabetes.55.01.06.db05-0613
Select this article
- Josef Endl,
- Silke Rosinger,
- Barbara Schwarz,
- Sven-Olaf Friedrich,
- Gregor Rothe,
- Wolfram Karges,
- Michael Schlosser,
- Thomas Eiermann,
- Dolores J. Schendel,
- and Bernhard O. Boehm
Coexpression of CD25 and OX40 (CD134) Receptors Delineates Autoreactive T-cells in Type 1 Diabetes
Diabetes January 2006 55:50-60; doi:10.2337/diabetes.55.01.06.db05-0387
Select this article
- Jo Harnaha,
- Jennifer Machen,
- Marietta Wright,
- Robert Lakomy,
- Alexis Styche,
- Massimo Trucco,
- Sami Makaroun,
- and Nick Giannoukakis
Interleukin-7 Is a Survival Factor for CD4⁺ CD25⁺ T-Cells and Is Expressed by Diabetes-Suppressive Dendritic Cells
Diabetes January 2006 55:158-170; doi:10.2337/diabetes.55.01.06.db05-0340
Select this article
- Chul-Ho Lee,
- Yi-Guang Chen,
- Jing Chen,
- Peter C. Reifsnyder,
- David V. Serreze,
- Michael Clare-Salzler,
- Michelle Rodriguez,
- Clive Wasserfall,
- Mark A. Atkinson,
- and Edward H. Leiter
Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis
Diabetes January 2006 55:171-178; doi:10.2337/diabetes.55.01.06.db05-1129
Select this article
- Marie-Alexandra Alyanakian,
- Françoise Grela,
- Aude Aumeunier,
- Carlo Chiavaroli,
- Christine Gouarin,
- Emilie Bardel,
- Gérard Normier,
- Lucienne Chatenoud,
- Nathalie Thieblemont,
- and Jean-François Bach
Transforming Growth Factor-β and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes
Diabetes January 2006 55:179-185; doi:10.2337/diabetes.55.01.06.db05-0189
Select this article
- Ute Christine Rogner,
- Françoise Lepault,
- Marie-Claude Gagnerault,
- David Vallois,
- Joëlle Morin,
- Philip Avner,
- and Christian Boitard
The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4⁺CD25⁺ Regulatory T-Cells
Diabetes January 2006 55:186-192; doi:10.2337/diabetes.55.01.06.db05-0598

Islet Studies

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- Aurélie V. Poll,
- Christophe E. Pierreux,
- Ludmilla Lokmane,
- Cécile Haumaitre,
- Younes Achouri,
- Patrick Jacquemin,
- Guy G. Rousseau,
- Silvia Cereghini,
- and Frédéric P. Lemaigre
A vHNF1/TCF2-HNF6 Cascade Regulates the Transcription Factor Network That Controls Generation of Pancreatic Precursor Cells
Diabetes January 2006 55:61-69; doi:10.2337/diabetes.55.01.06.db05-0681
Select this article
- Irene Cozar-Castellano,
- Matthew Weinstock,
- Marcia Haught,
- Silvia Velázquez-Garcia,
- Darinka Sipula,
- and Andrew F. Stewart
Evaluation of β-Cell Replication in Mice Transgenic for Hepatocyte Growth Factor and Placental Lactogen: Comprehensive Characterization of the G₁/S Regulatory Proteins Reveals Unique Involvement of p21^cip
Diabetes January 2006 55:70-77; doi:10.2337/diabetes.55.01.06.db05-0632
Select this article
- Zhidong Ling,
- Qidi Wang,
- Geert Stangé,
- Peter In’t Veld,
- and Daniel Pipeleers
Glibenclamide Treatment Recruits β-Cell Subpopulation Into Elevated and Sustained Basal Insulin Synthetic Activity
Diabetes January 2006 55:78-85; doi:10.2337/diabetes.55.01.06.db05-0820
Select this article
- Jichun Yang,
- Ryan K. Wong,
- MieJung Park,
- Jianmei Wu,
- Joshua R. Cook,
- David A. York,
- Shaoping Deng,
- James Markmann,
- Ali Naji,
- Bryan A. Wolf,
- and Zhiyong Gao
Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells
Diabetes January 2006 55:193-201; doi:10.2337/diabetes.55.01.06.db05-0938

Complications

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- Toshiyuki Oshitari,
- Peter Polewski,
- Manish Chadda,
- An-Fei Li,
- Tsuyoshi Sato,
- and Sayon Roy
Effect of Combined Antisense Oligonucleotides Against High-Glucose–and Diabetes-Induced Overexpression of Extracellular Matrix Components and Increased Vascular Permeability
Diabetes January 2006 55:86-92; doi:10.2337/diabetes.55.01.06.db05-0186
Select this article
- Geoff H. Werstuck,
- Mohammad I. Khan,
- Giuseppe Femia,
- Anna J. Kim,
- Vivienne Tedesco,
- Bernardo Trigatti,
- and Yuanyuan Shi
Glucosamine-Induced Endoplasmic Reticulum Dysfunction Is Associated With Accelerated Atherosclerosis in a Hyperglycemic Mouse Model
Diabetes January 2006 55:93-101; doi:10.2337/diabetes.55.01.06.db05-0633
Select this article
- Mark S. Segal,
- Ronak Shah,
- Aqeela Afzal,
- Cecile M. Perrault,
- Kyunghee Chang,
- Anna Schuler,
- Elaine Beem,
- Lynn C. Shaw,
- Sergio Li Calzi,
- Jeffrey K. Harrison,
- Roger Tran-Son-Tay,
- and Maria B. Grant
Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes
Diabetes January 2006 55:102-109; doi:10.2337/diabetes.55.01.06.db05-0803
Select this article
- Shanqin Xu,
- Bingbing Jiang,
- Karlene A. Maitland,
- Hossein Bayat,
- Jiali Gu,
- Jerry L. Nadler,
- Stefano Corda,
- Gilbert Lavielle,
- Tony J. Verbeuren,
- Adriana Zuccollo,
- and Richard A. Cohen
The Thromboxane Receptor Antagonist S18886 Attenuates Renal Oxidant Stress and Proteinuria in Diabetic Apolipoprotein E-Deficient Mice
Diabetes January 2006 55:110-119; doi:10.2337/diabetes.55.01.06.db05-0831
Select this article
- Daisuke Kukidome,
- Takeshi Nishikawa,
- Kazuhiro Sonoda,
- Koujiro Imoto,
- Kazuo Fujisawa,
- Miyuki Yano,
- Hiroyuki Motoshima,
- Tetsuya Taguchi,
- Takeshi Matsumura,
- and Eiichi Araki
Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells
Diabetes January 2006 55:120-127; doi:10.2337/diabetes.55.01.06.db05-0943
Select this article
- Katalin Susztak,
- Amanda C. Raff,
- Mario Schiffer,
- and Erwin P. Böttinger
Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy
Diabetes January 2006 55:225-233; doi:10.2337/diabetes.55.01.06.db05-0894
Select this article
- Romano Nosadini,
- Mario Velussi,
- Enrico Brocco,
- Cataldo Abaterusso,
- Andrea Carraro,
- Francesco Piarulli,
- Giuseppe Morgia,
- Andrea Satta,
- Rossana Faedda,
- Avinash Abhyankar,
- Holgher Luthman,
- and Giancarlo Tonolo
Increased Renal Arterial Resistance Predicts the Course of Renal Function in Type 2 Diabetes With Microalbuminuria
Diabetes January 2006 55:234-239; doi:10.2337/diabetes.55.01.06.db05-0881

Brief Genetics Reports

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- Jose C. Florez,
- Steven Wiltshire,
- Christina M. Agapakis,
- Noël P. Burtt,
- Paul I.W. de Bakker,
- Peter Almgren,
- Kristina Bengtsson Boström,
- Tiinamaija Tuomi,
- Daniel Gaudet,
- Mark J. Daly,
- Joel N. Hirschhorn,
- Mark I. McCarthy,
- David Altshuler,
- and Leif Groop
High-Density Haplotype Structure and Association Testing of the Insulin-Degrading Enzyme (IDE) Gene With Type 2 Diabetes in 4,206 People
Diabetes January 2006 55:128-135; doi:10.2337/diabetes.55.01.06.db05-0954
Select this article
- Jana Královičová,
- Tom R. Gaunt,
- Santiago Rodriguez,
- Peter J. Wood,
- Ian N.M. Day,
- and Igor Vořechovský
Variants in the Human Insulin Gene That Affect Pre-mRNA Splicing: Is −23HphI a Functional Single Nucleotide Polymorphism at IDDM2?
Diabetes January 2006 55:260-264; doi:10.2337/diabetes.55.01.06.db05-0773

Metabolism

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- Attila Brehm,
- Martin Krssak,
- Albrecht I. Schmid,
- Peter Nowotny,
- Werner Waldhäusl,
- and Michael Roden
Increased Lipid Availability Impairs Insulin-Stimulated ATP Synthesis in Human Skeletal Muscle
Diabetes January 2006 55:136-140; doi:10.2337/diabetes.55.01.06.db05-1286

Pathophysiology

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- Vijender R. Vaidyula,
- A. Koneti Rao,
- Maria Mozzoli,
- Carol Homko,
- Peter Cheung,
- and Guenther Boden
Effects of Hyperglycemia and Hyperinsulinemia on Circulating Tissue Factor Procoagulant Activity and Platelet CD40 Ligand
Diabetes January 2006 55:202-208; doi:10.2337/diabetes.55.01.06.db05-1026
Select this article
- Ana Fortuño,
- Gorka San José,
- María U. Moreno,
- Oscar Beloqui,
- Javier Díez,
- and Guillermo Zalba
Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome
Diabetes January 2006 55:209-215; doi:10.2337/diabetes.55.01.06.db05-0751
Select this article
- Carme Gubern,
- Abel López-Bermejo,
- Josefina Biarnés,
- Joan Vendrell,
- Wifredo Ricart,
- and José Manuel Fernández-Real
Natural Antibiotics and Insulin Sensitivity: The Role of Bactericidal/Permeability-Increasing Protein
Diabetes January 2006 55:216-224; doi:10.2337/diabetes.55.01.06.db05-1108

Pharmacology & Therapeutics

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- Thomas Harrity,
- Dennis Farrelly,
- Aaron Tieman,
- Cuixia Chu,
- Lori Kunselman,
- Liqun Gu,
- Randolph Ponticiello,
- Michael Cap,
- Fucheng Qu,
- Chunning Shao,
- Wei Wang,
- Hao Zhang,
- William Fenderson,
- Sean Chen,
- Pratik Devasthale,
- Yoon Jeon,
- Ramakrishna Seethala,
- Wen-Pin Yang,
- Jimmy Ren,
- Min Zhou,
- Denis Ryono,
- Scott Biller,
- Kasim A. Mookhtiar,
- John Wetterau,
- Richard Gregg,
- Peter T. Cheng,
- and Narayanan Hariharan
Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice
Diabetes January 2006 55:240-248; doi:10.2337/diabetes.55.01.06.db05-0648

Genetics

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- Cristina Lara-Castro,
- Nanlan Luo,
- Penny Wallace,
- Richard L. Klein,
- and W. Timothy Garvey
Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster
Diabetes January 2006 55:249-259; doi:10.2337/diabetes.55.01.06.db05-1105

Tribute

Select this article
- Boris Draznin
Karl Sussman, MD
Diabetes January 2006 55:265; doi:10.2337/diabetes.55.01.06.db06-tr01

Perspectives in Diabetes

The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy

New Methodology and Database

Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [18F]-DOPA Positron Emission Tomography

Obesity Studies

Y2Y4 Receptor Double Knockout Protects Against Obesity Due to a High-Fat Diet or Y1 Receptor Deficiency in Mice

Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells

Adipose Triglyceride Lipase: Function, Regulation by Insulin, and Comparison With Adiponutrin

Immunology and Transplantation

Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in the NOD Mouse

Natural Killer T-Cells Participate in Rejection of Islet Allografts in the Liver of Mice

Rapamycin and Interleukin-10 Treatment Induces T Regulatory Type 1 Cells That Mediate Antigen-Specific Transplantation Tolerance

Coexpression of CD25 and OX40 (CD134) Receptors Delineates Autoreactive T-cells in Type 1 Diabetes

Interleukin-7 Is a Survival Factor for CD4+ CD25+ T-Cells and Is Expressed by Diabetes-Suppressive Dendritic Cells

Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis

Transforming Growth Factor-β and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes

The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4+CD25+ Regulatory T-Cells

Islet Studies

A vHNF1/TCF2-HNF6 Cascade Regulates the Transcription Factor Network That Controls Generation of Pancreatic Precursor Cells

Evaluation of β-Cell Replication in Mice Transgenic for Hepatocyte Growth Factor and Placental Lactogen: Comprehensive Characterization of the G1/S Regulatory Proteins Reveals Unique Involvement of p21cip

Glibenclamide Treatment Recruits β-Cell Subpopulation Into Elevated and Sustained Basal Insulin Synthetic Activity

Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Complications

Effect of Combined Antisense Oligonucleotides Against High-Glucose–and Diabetes-Induced Overexpression of Extracellular Matrix Components and Increased Vascular Permeability

Glucosamine-Induced Endoplasmic Reticulum Dysfunction Is Associated With Accelerated Atherosclerosis in a Hyperglycemic Mouse Model

Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes

The Thromboxane Receptor Antagonist S18886 Attenuates Renal Oxidant Stress and Proteinuria in Diabetic Apolipoprotein E-Deficient Mice

Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells

Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy

Increased Renal Arterial Resistance Predicts the Course of Renal Function in Type 2 Diabetes With Microalbuminuria

Brief Genetics Reports

High-Density Haplotype Structure and Association Testing of the Insulin-Degrading Enzyme (IDE) Gene With Type 2 Diabetes in 4,206 People

Variants in the Human Insulin Gene That Affect Pre-mRNA Splicing: Is −23HphI a Functional Single Nucleotide Polymorphism at IDDM2?

Metabolism

Increased Lipid Availability Impairs Insulin-Stimulated ATP Synthesis in Human Skeletal Muscle

Pathophysiology

Effects of Hyperglycemia and Hyperinsulinemia on Circulating Tissue Factor Procoagulant Activity and Platelet CD40 Ligand

Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome

Natural Antibiotics and Insulin Sensitivity: The Role of Bactericidal/Permeability-Increasing Protein

Pharmacology & Therapeutics

Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice

Genetics

Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster

Tribute

Karl Sussman, MD

This Issue

Current Issue

Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [¹⁸F]-DOPA Positron Emission Tomography

Interleukin-7 Is a Survival Factor for CD4⁺ CD25⁺ T-Cells and Is Expressed by Diabetes-Suppressive Dendritic Cells

The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4⁺CD25⁺ Regulatory T-Cells

Evaluation of β-Cell Replication in Mice Transgenic for Hepatocyte Growth Factor and Placental Lactogen: Comprehensive Characterization of the G₁/S Regulatory Proteins Reveals Unique Involvement of p21^cip