Table of Contents

October 2006; 55 (10)

Signal Transduction

    • Sarah L. Gray,
    • Edoardo Dalla Nora,
    • Johannes Grosse,
    • Monia Manieri,
    • Tobias Stoeger,
    • Gema Medina-Gomez,
    • Keith Burling,
    • Sigrid Wattler,
    • Andreas Russ,
    • Giles S.H. Yeo,
    • V. Krishna Chatterjee,
    • Stephen O’Rahilly,
    • Peter J. Voshol,
    • Saverio Cinti,
    • and Antonio Vidal-Puig

    Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice

    Diabetes October 2006 55:2669-2677; doi:10.2337/db06-0389
    • Kristin M. Beard,
    • Huogen Lu,
    • Karen Ho,
    • and I. George Fantus

    Bradykinin Augments Insulin-Stimulated Glucose Transport in Rat Adipocytes via Endothelial Nitric Oxide Synthase–Mediated Inhibition of Jun NH2-Terminal Kinase

    Diabetes October 2006 55:2678-2687; doi:10.2337/db05-1538
    • Andrew L. Carey,
    • Gregory R. Steinberg,
    • S. Lance Macaulay,
    • Walter G. Thomas,
    • Anna G. Holmes,
    • Georg Ramm,
    • Oja Prelovsek,
    • Cordula Hohnen-Behrens,
    • Matthew J. Watt,
    • David E. James,
    • Bruce E. Kemp,
    • Bente K. Pedersen,
    • and Mark A. Febbraio

    Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

    Diabetes October 2006 55:2688-2697; doi:10.2337/db05-1404
    • Mathieu Laplante,
    • William T. Festuccia,
    • Geneviève Soucy,
    • Yves Gélinas,
    • Josée Lalonde,
    • Joel P. Berger,
    • and Yves Deshaies

    Mechanisms of the Depot Specificity of Peroxisome Proliferator–Activated Receptor γ Action on Adipose Tissue Metabolism

    Diabetes October 2006 55:2771-2778; doi:10.2337/db06-0551
    • Teresa Coll,
    • Mireia Jové,
    • Ricardo Rodríguez-Calvo,
    • Elena Eyre,
    • Xavier Palomer,
    • Rosa M. Sánchez,
    • Manuel Merlos,
    • Juan Carlos Laguna,
    • and Manuel Vázquez-Carrera

    Palmitate-Mediated Downregulation of Peroxisome Proliferator–Activated Receptor-γ Coactivator 1α in Skeletal Muscle Cells Involves MEK1/2 and Nuclear Factor-κB Activation

    Diabetes October 2006 55:2779-2787; doi:10.2337/db05-1494
    • Radhika H. Muzumdar,
    • Xiaohui Ma,
    • Sigal Fishman,
    • Xiaoman Yang,
    • Gil Atzmon,
    • Patricia Vuguin,
    • Francine H. Einstein,
    • David Hwang,
    • Pinchas Cohen,
    • and Nir Barzilai

    Central and Opposing Effects of IGF-I and IGF-Binding Protein-3 on Systemic Insulin Action

    Diabetes October 2006 55:2788-2796; doi:10.2337/db06-0318
    • Ji-Ming Ye,
    • Nick Dzamko,
    • Andrew J. Hoy,
    • Miguel A. Iglesias,
    • Bruce Kemp,
    • and Edward Kraegen

    Rosiglitazone Treatment Enhances Acute AMP-Activated Protein Kinase–Mediated Muscle and Adipose Tissue Glucose Uptake in High-Fat–Fed Rats

    Diabetes October 2006 55:2797-2804; doi:10.2337/db05-1315

Obesity Studies

    • H. Roger Lijnen,
    • Valerie Christiaens,
    • Ilse Scroyen,
    • Gabor Voros,
    • Marc Tjwa,
    • Peter Carmeliet,
    • and Désiré Collen

    Impaired Adipose Tissue Development in Mice With Inactivation of Placental Growth Factor Function

    Diabetes October 2006 55:2698-2704; doi:10.2337/db06-0526
    • Jürgen Janke,
    • Stefan Engeli,
    • Michael Boschmann,
    • Frauke Adams,
    • Jana Böhnke,
    • Friedrich C. Luft,
    • Arya M. Sharma,
    • and Jens Jordan

    Retinol-Binding Protein 4 in Human Obesity

    Diabetes October 2006 55:2805-2810; doi:10.2337/db06-0616
    • Aiwei Yao-Borengasser,
    • Neda Rasouli,
    • Vijayalakshmi Varma,
    • Leslie M. Miles,
    • Bounleut Phanavanh,
    • Tasha N. Starks,
    • Jack Phan,
    • Horace J. Spencer III,
    • Robert E. McGehee, Jr.,
    • Karen Reue,
    • and Philip A. Kern

    Lipin Expression Is Attenuated in Adipose Tissue of Insulin-Resistant Human Subjects and Increases With Peroxisome Proliferator–Activated Receptor γ Activation

    Diabetes October 2006 55:2811-2818; doi:10.2337/db05-1688

Islet Studies

    • Malene Jackerott,
    • Annette Møldrup,
    • Peter Thams,
    • Elisabeth D. Galsgaard,
    • Jakob Knudsen,
    • Ying C. Lee,
    • and Jens Høiriis Nielsen

    STAT5 Activity in Pancreatic β-Cells Influences the Severity of Diabetes in Animal Models of Type 1 and 2 Diabetes

    Diabetes October 2006 55:2705-2712; doi:10.2337/db06-0244
    • Kathrin Maedler,
    • Desiree M. Schumann,
    • Nadine Sauter,
    • Helga Ellingsgaard,
    • Domenico Bosco,
    • Reto Baertschiger,
    • Yoichiro Iwakura,
    • José Oberholzer,
    • Claes B. Wollheim,
    • Benoit R. Gauthier,
    • and Marc Y. Donath

    Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets

    Diabetes October 2006 55:2713-2722; doi:10.2337/db05-1430
    • Thomas Kaido,
    • Mayra Yebra,
    • Vincenzo Cirulli,
    • Christopher Rhodes,
    • Giuseppe Diaferia,
    • and Anthony M. Montgomery

    Impact of Defined Matrix Interactions on Insulin Production by Cultured Human β-Cells: Effect on Insulin Content, Secretion, and Gene Transcription

    Diabetes October 2006 55:2723-2729; doi:10.2337/db06-0120
    • Marko Z. Vatamaniuk,
    • Rana K. Gupta,
    • Kristen A. Lantz,
    • Nicolai M. Doliba,
    • Franz M. Matschinsky,
    • and Klaus H. Kaestner

    Foxa1-Deficient Mice Exhibit Impaired Insulin Secretion due to Uncoupled Oxidative Phosphorylation

    Diabetes October 2006 55:2730-2736; doi:10.2337/db05-0470
    • James D. Johnson,
    • Eric L. Ford,
    • Ernesto Bernal-Mizrachi,
    • Kim L. Kusser,
    • Dan S. Luciani,
    • Zhiqiang Han,
    • Hung Tran,
    • Troy D. Randall,
    • Frances E. Lund,
    • and Kenneth S. Polonsky

    Suppressed Insulin Signaling and Increased Apoptosis in Cd38-Null Islets

    Diabetes October 2006 55:2737-2746; doi:10.2337/db05-1455
    • Shinya Nagamatsu,
    • Mica Ohara-Imaizumi,
    • Yoko Nakamichi,
    • Toshiteru Kikuta,
    • and Chiyono Nishiwaki

    Imaging Docking and Fusion of Insulin Granules Induced by Antidiabetes Agents: Sulfonylurea and Glinide Drugs Preferentially Mediate the Fusion of Newcomer, but Not Previously Docked, Insulin Granules

    Diabetes October 2006 55:2819-2825; doi:10.2337/db06-0105
    • Karsten Buschard,
    • Maria Blomqvist,
    • Jan-Eric Månsson,
    • Pam Fredman,
    • Kirstine Juhl,
    • and Jesper Gromada

    C16:0 Sulfatide Inhibits Insulin Secretion in Rat β-Cells by Reducing the Sensitivity of KATP Channels to ATP Inhibition

    Diabetes October 2006 55:2826-2834; doi:10.2337/db05-1355
    • Dany Muller,
    • Guo Cai Huang,
    • Stephanie Amiel,
    • Peter M. Jones,
    • and Shanta J. Persaud

    Identification of Insulin Signaling Elements in Human β-Cells: Autocrine Regulation of Insulin Gene Expression

    Diabetes October 2006 55:2835-2842; doi:10.2337/db06-0532

Complications

    • Hisashi Makino,
    • Yoshihiro Miyamoto,
    • Kazutomo Sawai,
    • Kiyoshi Mori,
    • Masashi Mukoyama,
    • Kazuwa Nakao,
    • Yasunao Yoshimasa,
    • and Shin-ichi Suga

    Altered Gene Expression Related to Glomerulogenesis and Podocyte Structure in Early Diabetic Nephropathy of db/db Mice and Its Restoration by Pioglitazone

    Diabetes October 2006 55:2747-2756; doi:10.2337/db05-1683
    • Wei Sun,
    • Peter J. Oates,
    • James B. Coutcher,
    • Chiara Gerhardinger,
    • and Mara Lorenzi

    A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy

    Diabetes October 2006 55:2757-2762; doi:10.2337/db06-0138
    • Ana I. Duarte,
    • Teresa Proença,
    • Catarina R. Oliveira,
    • Maria S. Santos,
    • and A. Cristina Rego

    Insulin Restores Metabolic Function in Cultured Cortical Neurons Subjected to Oxidative Stress

    Diabetes October 2006 55:2863-2870; doi:10.2337/db06-0030

Genetics

    • Teresa Soccio,
    • Yuan-Yuan Zhang,
    • Simonetta Bacci,
    • Wojciech Mlynarski,
    • Grzegorz Placha,
    • Greer Raggio,
    • Rosa Di Paola,
    • Antonella Marucci,
    • Michael T. Johnstone,
    • Ernest V. Gervino,
    • Nada A. Abumrad,
    • Samuel Klein,
    • Vincenzo Trischitta,
    • and Alessandro Doria

    Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes

    Diabetes October 2006 55:2763-2770; doi:10.2337/db06-0613
    • Michael Benzinou,
    • Andrew Walley,
    • Stephan Lobbens,
    • Marie-Aline Charles,
    • Béatrice Jouret,
    • Frédéric Fumeron,
    • Beverley Balkau,
    • David Meyre,
    • and Philippe Froguel

    Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians

    Diabetes October 2006 55:2876-2882; doi:10.2337/db06-0337
    • Suna Onengut-Gumuscu,
    • Jane H. Buckner,
    • and Patrick Concannon

    A Haplotype-Based Analysis of the PTPN22 Locus in Type 1 Diabetes

    Diabetes October 2006 55:2883-2889; doi:10.2337/db06-0225

Pathophysiology

    • Heidi Sørensen,
    • Christian L. Brand,
    • Susanne Neschen,
    • Jens Juul Holst,
    • Keld Fosgerau,
    • Erica Nishimura,
    • and Gerald I. Shulman

    Immunoneutralization of Endogenous Glucagon Reduces Hepatic Glucose Output and Improves Long-Term Glycemic Control in Diabetic ob/ob Mice

    Diabetes October 2006 55:2843-2848; doi:10.2337/db06-0222
    • Dominic N. Reeds,
    • W. Todd Cade,
    • Bruce W. Patterson,
    • William G. Powderly,
    • Samuel Klein,
    • and Kevin E. Yarasheski

    Whole-Body Proteolysis Rate Is Elevated in HIV-Associated Insulin Resistance

    Diabetes October 2006 55:2849-2855; doi:10.2337/db06-0255
    • Simin Liu,
    • I-Min Lee,
    • Yiqing Song,
    • Martin Van Denburgh,
    • Nancy R. Cook,
    • JoAnn E. Manson,
    • and Julie E. Buring

    Vitamin E and Risk of Type 2 Diabetes in the Women’s Health Study Randomized Controlled Trial

    Diabetes October 2006 55:2856-2862; doi:10.2337/db06-0456

Pharmacology and Therapeutics

    • Abel López-Bermejo,
    • Berta Chico-Julià,
    • Mercè Fernàndez-Balsells,
    • Mònica Recasens,
    • Eduardo Esteve,
    • Roser Casamitjana,
    • Wifredo Ricart,
    • and José-Manuel Fernández-Real

    Serum Visfatin Increases With Progressive β-Cell Deterioration

    Diabetes October 2006 55:2871-2875; doi:10.2337/db06-0259

Brief Genetics Reports

    • Richa Saxena,
    • Lauren Gianniny,
    • Noël P. Burtt,
    • Valeriya Lyssenko,
    • Candace Giuducci,
    • Marketa Sjögren,
    • Jose C. Florez,
    • Peter Almgren,
    • Bo Isomaa,
    • Marju Orho-Melander,
    • Ulf Lindblad,
    • Mark J. Daly,
    • Tiinamaija Tuomi,
    • Joel N. Hirschhorn,
    • Kristin G. Ardlie,
    • Leif C. Groop,
    • and David Altshuler

    Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic Individuals

    Diabetes October 2006 55:2890-2895; doi:10.2337/db06-0381
    • Swneke D. Bailey,
    • J C. Loredo-Osti,
    • Pierre Lepage,
    • Janet Faith,
    • Joelle Fontaine,
    • Katia M. Desbiens,
    • Thomas J. Hudson,
    • Claude Bouchard,
    • Daniel Gaudet,
    • Louis Pérusse,
    • Marie-Claude Vohl,
    • and James C. Engert

    Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population

    Diabetes October 2006 55:2896-2902; doi:10.2337/db06-0189
    • Stéphane Cauchi,
    • David Meyre,
    • Christian Dina,
    • Hélène Choquet,
    • Chantal Samson,
    • Sophie Gallina,
    • Beverley Balkau,
    • Guillaume Charpentier,
    • François Pattou,
    • Volodymyr Stetsyuk,
    • Raphaël Scharfmann,
    • Bart Staels,
    • Gema Frühbeck,
    • and Philippe Froguel

    Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

    Diabetes October 2006 55:2903-2908; doi:10.2337/db06-0474
    • Steven C. Elbein,
    • Xiaoqin Wang,
    • Mohammad A. Karim,
    • Barry I. Freedman,
    • Donald W. Bowden,
    • Alan R. Shuldiner,
    • Frederick L. Brancati,
    • and Wen Hong Linda Kao

    Role of a Proline Insertion in the Insulin Promoter Factor 1 (IPF1) Gene in African Americans With Type 2 Diabetes

    Diabetes October 2006 55:2909-2914; doi:10.2337/db06-0434
    • Cornelia Huth,
    • Iris M. Heid,
    • Caren Vollmert,
    • Christian Gieger,
    • Harald Grallert,
    • Johanna K. Wolford,
    • Birgit Langer,
    • Barbara Thorand,
    • Norman Klopp,
    • Yasmin H. Hamid,
    • Oluf Pedersen,
    • Torben Hansen,
    • Valeriya Lyssenko,
    • Leif Groop,
    • Christa Meisinger,
    • Angela Döring,
    • Hannelore Löwel,
    • Wolfgang Lieb,
    • Christian Hengstenberg,
    • Wolfgang Rathmann,
    • Stephan Martin,
    • Jeffrey W. Stephens,
    • Helen Ireland,
    • Hugh Mather,
    • George J. Miller,
    • Heather M. Stringham,
    • Michael Boehnke,
    • Jaakko Tuomilehto,
    • Heiner Boeing,
    • Matthias Möhlig,
    • Joachim Spranger,
    • Andreas Pfeiffer,
    • Ingrid Wernstedt,
    • Anders Niklason,
    • Abel López-Bermejo,
    • José-Manuel Fernández-Real,
    • Robert L. Hanson,
    • Luis Gallart,
    • Joan Vendrell,
    • Anastasia Tsiavou,
    • Erifili Hatziagelaki,
    • Steve E. Humphries,
    • H.-Erich Wichmann,
    • Christian Herder,
    • and Thomas Illig

    IL6 Gene Promoter Polymorphisms and Type 2 Diabetes: Joint Analysis of Individual Participants’ Data From 21 Studies

    Diabetes October 2006 55:2915-2921; doi:10.2337/db06-0600
    • Mojgan Yazdanpanah,
    • Fakhredin A. Sayed-Tabatabaei,
    • Albert Hofman,
    • Yurii S. Aulchenko,
    • Ben A. Oostra,
    • Bruno H.C. Stricker,
    • Huibert A.P. Pols,
    • Steven W.J. Lamberts,
    • Jacqueline C.M. Witteman,
    • Joop A.M.J.L. Janssen,
    • and Cornelia M. van Duijn

    The α-Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes

    Diabetes October 2006 55:2922-2927; doi:10.2337/db06-0302
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This Issue

October 2006; 55 (10)
  1. Signal Transduction
  2. Obesity Studies
  3. Islet Studies
  4. Complications
  5. Genetics
  6. Pathophysiology
  7. Pharmacology and Therapeutics
  8. Brief Genetics Reports

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