Table of Contents

New Methodologies and Databases

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- Joo Ho Tai,
- Paula Foster,
- Alma Rosales,
- Biao Feng,
- Craig Hasilo,
- Violetta Martinez,
- Soha Ramadan,
- Jonatan Snir,
- C.W. James Melling,
- Savita Dhanvantari,
- Brian Rutt,
- and David J.G. White
Imaging Islets Labeled With Magnetic Nanoparticles at 1.5 Tesla
Diabetes November 2006 55:2931-2938; doi:10.2337/db06-0393

Obesity Studies

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- Jiyoung Park,
- Sung Sik Choe,
- A Hyun Choi,
- Kang Ho Kim,
- Myeong Jin Yoon,
- Takayoshi Suganami,
- Yoshihiro Ogawa,
- and Jae Bum Kim
Increase in Glucose-6-Phosphate Dehydrogenase in Adipocytes Stimulates Oxidative Stress and Inflammatory Signals
Diabetes November 2006 55:2939-2949; doi:10.2337/db05-1570
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- Prasanth K. Chelikani,
- Alvin C. Haver,
- and Roger D. Reidelberger
Ghrelin Attenuates the Inhibitory Effects of Glucagon-Like Peptide-1 and Peptide YY(3-36) on Food Intake and Gastric Emptying in Rats
Diabetes November 2006 55:3038-3046; doi:10.2337/db06-0730
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- Jenny M. Kindblom,
- Mattias Lorentzon,
- Ensio Norjavaara,
- Lars Lönn,
- John Brandberg,
- Jan-Erik Angelhed,
- Åsa Hellqvist,
- Staffan Nilsson,
- and Claes Ohlsson
Pubertal Timing Is an Independent Predictor of Central Adiposity in Young Adult Males: The Gothenburg Osteoporosis and Obesity Determinants Study
Diabetes November 2006 55:3047-3052; doi:10.2337/db06-0192
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- Matthias Blüher,
- Stefan Engeli,
- Nora Klöting,
- Janin Berndt,
- Mathias Fasshauer,
- Sándor Bátkai,
- Pál Pacher,
- Michael R. Schön,
- Jens Jordan,
- and Michael Stumvoll
Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity
Diabetes November 2006 55:3053-3060; doi:10.2337/db06-0812

Islet Studies

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- Senta Georgia and
- Anil Bhushan
p27 Regulates the Transition of β-Cells From Quiescence to Proliferation
Diabetes November 2006 55:2950-2956; doi:10.2337/db06-0249
Select this article
- Joseph C. Koster,
- Maria S. Remedi,
- Ricard Masia,
- Brian Patton,
- Ailing Tong,
- and Colin G. Nichols
Expression of ATP-Insensitive K_ATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes
Diabetes November 2006 55:2957-2964; doi:10.2337/db06-0732
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- Xianquan Li,
- Lanjing Zhang,
- Sasha Meshinchi,
- Claudia Dias-Leme,
- Diane Raffin,
- Jeffery D. Johnson,
- Mary K. Treutelaar,
- and Charles F. Burant
Islet Microvasculature in Islet Hyperplasia and Failure in a Model of Type 2 Diabetes
Diabetes November 2006 55:2965-2973; doi:10.2337/db06-0733
Select this article
- Marcela Brissova,
- Alena Shostak,
- Masakazu Shiota,
- Peter O. Wiebe,
- Greg Poffenberger,
- Jeannelle Kantz,
- Zhongyi Chen,
- Chad Carr,
- W. Gray Jerome,
- Jin Chen,
- H. Scott Baldwin,
- Wendell Nicholson,
- David M. Bader,
- Thomas Jetton,
- Maureen Gannon,
- and Alvin C. Powers
Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function
Diabetes November 2006 55:2974-2985; doi:10.2337/db06-0690
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- Andrei I. Tarasov,
- Hannah J. Welters,
- Sabine Senkel,
- Gerhart U. Ryffel,
- Andrew T. Hattersley,
- Noel G. Morgan,
- and Frances M. Ashcroft
A Kir6.2 Mutation Causing Neonatal Diabetes Impairs Electrical Activity and Insulin Secretion From INS-1 β-Cells
Diabetes November 2006 55:3075-3082; doi:10.2337/db06-0637

Pathophysiology

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- Karen Anthony,
- Laurence J. Reed,
- Joel T. Dunn,
- Emma Bingham,
- David Hopkins,
- Paul K. Marsden,
- and Stephanie A. Amiel
Attenuation of Insulin-Evoked Responses in Brain Networks Controlling Appetite and Reward in Insulin Resistance: The Cerebral Basis for Impaired Control of Food Intake in Metabolic Syndrome?
Diabetes November 2006 55:2986-2992; doi:10.2337/db06-0376
Select this article
- Yong Qi,
- Zhenying Nie,
- Yun-Sik Lee,
- Neel S. Singhal,
- Philipp E. Scherer,
- Mitchell A. Lazar,
- and Rexford S. Ahima
Loss of Resistin Improves Glucose Homeostasis in Leptin Deficiency
Diabetes November 2006 55:3083-3090; doi:10.2337/db05-0615
Select this article
- Hiralben R. Patel,
- Yong Qi,
- Evan J. Hawkins,
- Stanley M. Hileman,
- Joel K. Elmquist,
- Yumi Imai,
- and Rexford S. Ahima
Neuropeptide Y Deficiency Attenuates Responses to Fasting and High-Fat Diet in Obesity-Prone Mice
Diabetes November 2006 55:3091-3098; doi:10.2337/db05-0624

Complications

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- Holger Schmid,
- Anissa Boucherot,
- Yoshinari Yasuda,
- Anna Henger,
- Bodo Brunner,
- Felix Eichinger,
- Almut Nitsche,
- Eva Kiss,
- Markus Bleich,
- Hermann-Josef Gröne,
- Peter J. Nelson,
- Detlef Schlöndorff,
- Clemens D. Cohen,
- and Matthias Kretzler
Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy
Diabetes November 2006 55:2993-3003; doi:10.2337/db06-0477
Select this article
- Csaba Szabó,
- Alisha Biser,
- Rita Benkő,
- Erwin Böttinger,
- and Katalin Suszták
Poly(ADP-Ribose) Polymerase Inhibitors Ameliorate Nephropathy of Type 2 Diabetic Lepr^db/db Mice
Diabetes November 2006 55:3004-3012; doi:10.2337/db06-0147
Select this article
- Maria Mastorikou,
- Mike Mackness,
- and Bharti Mackness
Defective Metabolism of Oxidized Phospholipid by HDL From People With Type 2 Diabetes
Diabetes November 2006 55:3099-3103; doi:10.2337/db06-0723
Select this article
- Harkiran Kaur,
- Shali Chen,
- Xiping Xin,
- Jane Chiu,
- Zia A. Khan,
- and Subrata Chakrabarti
Diabetes-Induced Extracellular Matrix Protein Expression Is Mediated by Transcription Coactivator p300
Diabetes November 2006 55:3104-3111; doi:10.2337/db06-0519
Select this article
- Yuzuru Ohshiro,
- Ronald C. Ma,
- Yutaka Yasuda,
- Junko Hiraoka-Yamamoto,
- Allen C. Clermont,
- Keiji Isshiki,
- Kunimasa Yagi,
- Emi Arikawa,
- Timothy S. Kern,
- and George L. King
Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice
Diabetes November 2006 55:3112-3120; doi:10.2337/db06-0895
Select this article
- Katrin Staiger,
- Harald Staiger,
- Cora Weigert,
- Carina Haas,
- Hans-Ulrich Häring,
- and Monika Kellerer
Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-κB Activation
Diabetes November 2006 55:3121-3126; doi:10.2337/db06-0188
Select this article
- W. Stephen Waring,
- John A. McKnight,
- David J. Webb,
- and Simon R.J. Maxwell
Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers
Diabetes November 2006 55:3127-3132; doi:10.2337/db06-0283
Select this article
- Hong Nie,
- Ji-liang Wu,
- Miao Zhang,
- Jian Xu,
- and Ming-Hui Zou
Endothelial Nitric Oxide Synthase–Dependent Tyrosine Nitration of Prostacyclin Synthase in Diabetes In Vivo
Diabetes November 2006 55:3133-3141; doi:10.2337/db06-0505

Metabolism

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- Rita Basu,
- Dale S. Edgerton,
- Ravinder J. Singh,
- Alan Cherrington,
- and Robert A. Rizza
Splanchnic Cortisol Production in Dogs Occurs Primarily in the Liver: Evidence for Substantial Hepatic Specific 11β Hydroxysteroid Dehydrogenase Type 1 Activity
Diabetes November 2006 55:3013-3019; doi:10.2337/db06-0601
Select this article
- Henriette Pilegaard,
- Jesper B. Birk,
- Massimo Sacchetti,
- Marina Mourtzakis,
- D. Graham Hardie,
- Greg Stewart,
- P. Darrell Neufer,
- Bengt Saltin,
- Gerrit van Hall,
- and Jorgen F.P. Wojtaszewski
PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise: Effect of Intralipid Infusion
Diabetes November 2006 55:3020-3027; doi:10.2337/db06-0152
Select this article
- Alessandra Bertoldo,
- R. Richard Pencek,
- Koichiro Azuma,
- Julie C. Price,
- Carol Kelley,
- Claudio Cobelli,
- and David E. Kelley
Interactions Between Delivery, Transport, and Phosphorylation of Glucose in Governing Uptake Into Human Skeletal Muscle
Diabetes November 2006 55:3028-3037; doi:10.2337/db06-0762

Immunology and Transplantation

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- Nathan E. Standifer,
- Qin Ouyang,
- Constadina Panagiotopoulos,
- C. Bruce Verchere,
- Rusung Tan,
- Carla J. Greenbaum,
- Catherine Pihoker,
- and Gerald T. Nepom
Identification of Novel HLA-A*0201–Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives
Diabetes November 2006 55:3061-3067; doi:10.2337/db06-0066
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- Qin Ouyang,
- Nathan E. Standifer,
- Huilian Qin,
- Peter Gottlieb,
- C. Bruce Verchere,
- Gerald T. Nepom,
- Rusung Tan,
- and Constadina Panagiotopoulos
Recognition of HLA Class I–Restricted β-Cell Epitopes in Type 1 Diabetes
Diabetes November 2006 55:3068-3074; doi:10.2337/db06-0065

Pharmacology and Therapeutics

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- Ranganath Muniyappa,
- Rajaram J. Karne,
- Gail Hall,
- Sonja K. Crandon,
- Joel A. Bronstein,
- Maria R. Ver,
- Glen L. Hortin,
- and Michael J. Quon
Oral Glucosamine for 6 Weeks at Standard Doses Does Not Cause or Worsen Insulin Resistance or Endothelial Dysfunction in Lean or Obese Subjects
Diabetes November 2006 55:3142-3150; doi:10.2337/db06-0714
Select this article
- Greet Van den Berghe,
- Alexander Wilmer,
- Ilse Milants,
- Pieter J. Wouters,
- Bernard Bouckaert,
- Frans Bruyninckx,
- Roger Bouillon,
- and Miet Schetz
Intensive Insulin Therapy in Mixed Medical/Surgical Intensive Care Units: Benefit Versus Harm
Diabetes November 2006 55:3151-3159; doi:10.2337/db06-0855

Genetics

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- Michael T. Traurig,
- Paska A. Permana,
- Saraswathy Nair,
- Sayuko Kobes,
- Clifton Bogardus,
- and Leslie J. Baier
Differential Expression of Matrix Metalloproteinase 3 (MMP3) in Preadipocytes/Stromal Vascular Cells From Nonobese Nondiabetic Versus Obese Nondiabetic Pima Indians
Diabetes November 2006 55:3160-3165; doi:10.2337/db06-0373
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- Nathalie Vionnet,
- David Tregouët,
- Gbenga Kazeem,
- Ivo Gut,
- Per-Henrik Groop,
- Lise Tarnow,
- Hans-Henrik Parving,
- Samy Hadjadj,
- Carol Forsblom,
- Martin Farrall,
- Dominique Gauguier,
- Roger Cox,
- Fumihiko Matsuda,
- Simon Heath,
- Alexandre Thévard,
- Rachel Rousseau,
- François Cambien,
- Michel Marre,
- and Mark Lathrop
Analysis of 14 Candidate Genes for Diabetic Nephropathy on Chromosome 3q in European Populations: Strongest Evidence for Association With a Variant in the Promoter Region of the Adiponectin Gene
Diabetes November 2006 55:3166-3174; doi:10.2337/db06-0271

Brief Genetics Reports

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- Michael N. Weedon,
- Beverley Shields,
- Graham Hitman,
- Mark Walker,
- Mark I. McCarthy,
- Andrew T. Hattersley,
- and Timothy M. Frayling
No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians
Diabetes November 2006 55:3175-3179; doi:10.2337/db06-0410
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- Helen N. Lyon,
- Jose C. Florez,
- Todd Bersaglieri,
- Richa Saxena,
- Wendy Winckler,
- Peter Almgren,
- Ulf Lindblad,
- Tiinamaija Tuomi,
- Daniel Gaudet,
- Xiaofeng Zhu,
- Richard Cooper,
- Kristin G. Ardlie,
- Mark J. Daly,
- David Altshuler,
- Leif Groop,
- and Joel N. Hirschhorn
Common Variants in the ENPP1 Gene Are Not Reproducibly Associated With Diabetes or Obesity
Diabetes November 2006 55:3180-3184; doi:10.2337/db06-0407
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- Kathleen M. Gillespie,
- Rachel J. Dix,
- Alistair J.K. Williams,
- Richard Newton,
- Zoey F. Robinson,
- Polly J. Bingley,
- Edwin A.M. Gale,
- and Julian P.H. Shield
Islet Autoimmunity in Children With Down’s Syndrome
Diabetes November 2006 55:3185-3188; doi:10.2337/db06-0856
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- Stéphane Cauchi,
- David Meyre,
- Hélène Choquet,
- Christian Dina,
- Catherine Born,
- Michel Marre,
- Beverley Balkau,
- and Philippe Froguel
TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population : The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study
Diabetes November 2006 55:3189-3192; doi:10.2337/db06-0692
Select this article
- Els C. van Hove,
- Torben Hansen,
- Jacqueline M. Dekker,
- Erwin Reiling,
- Giel Nijpels,
- Torben Jørgensen,
- Knut Borch-Johnsen,
- Yasmin H. Hamid,
- Robert J. Heine,
- Oluf Pedersen,
- J. Antonie Maassen,
- and Leen M. 't Hart
The HADHSC Gene Encoding Short-Chain l-3-Hydroxyacyl-CoA Dehydrogenase (SCHAD) and Type 2 Diabetes Susceptibility : The DAMAGE Study
Diabetes November 2006 55:3193-3196; doi:10.2337/db06-0414

Erratum

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Erratum
Diabetes November 2006 55:3197; doi:10.2337/db06-er11

Diabetes

New Methodologies and Databases

Imaging Islets Labeled With Magnetic Nanoparticles at 1.5 Tesla

Obesity Studies

Increase in Glucose-6-Phosphate Dehydrogenase in Adipocytes Stimulates Oxidative Stress and Inflammatory Signals

Ghrelin Attenuates the Inhibitory Effects of Glucagon-Like Peptide-1 and Peptide YY(3-36) on Food Intake and Gastric Emptying in Rats

Pubertal Timing Is an Independent Predictor of Central Adiposity in Young Adult Males: The Gothenburg Osteoporosis and Obesity Determinants Study

Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity

Islet Studies

p27 Regulates the Transition of β-Cells From Quiescence to Proliferation

Expression of ATP-Insensitive KATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes

Islet Microvasculature in Islet Hyperplasia and Failure in a Model of Type 2 Diabetes

Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function

A Kir6.2 Mutation Causing Neonatal Diabetes Impairs Electrical Activity and Insulin Secretion From INS-1 β-Cells

Pathophysiology

Attenuation of Insulin-Evoked Responses in Brain Networks Controlling Appetite and Reward in Insulin Resistance: The Cerebral Basis for Impaired Control of Food Intake in Metabolic Syndrome?

Loss of Resistin Improves Glucose Homeostasis in Leptin Deficiency

Neuropeptide Y Deficiency Attenuates Responses to Fasting and High-Fat Diet in Obesity-Prone Mice

Complications

Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy

Poly(ADP-Ribose) Polymerase Inhibitors Ameliorate Nephropathy of Type 2 Diabetic Leprdb/db Mice

Defective Metabolism of Oxidized Phospholipid by HDL From People With Type 2 Diabetes

Diabetes-Induced Extracellular Matrix Protein Expression Is Mediated by Transcription Coactivator p300

Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice

Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-κB Activation

Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers

Endothelial Nitric Oxide Synthase–Dependent Tyrosine Nitration of Prostacyclin Synthase in Diabetes In Vivo

Metabolism

Splanchnic Cortisol Production in Dogs Occurs Primarily in the Liver: Evidence for Substantial Hepatic Specific 11β Hydroxysteroid Dehydrogenase Type 1 Activity

PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise: Effect of Intralipid Infusion

Interactions Between Delivery, Transport, and Phosphorylation of Glucose in Governing Uptake Into Human Skeletal Muscle

Immunology and Transplantation

Identification of Novel HLA-A*0201–Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives

Recognition of HLA Class I–Restricted β-Cell Epitopes in Type 1 Diabetes

Pharmacology and Therapeutics

Oral Glucosamine for 6 Weeks at Standard Doses Does Not Cause or Worsen Insulin Resistance or Endothelial Dysfunction in Lean or Obese Subjects

Intensive Insulin Therapy in Mixed Medical/Surgical Intensive Care Units: Benefit Versus Harm

Genetics

Differential Expression of Matrix Metalloproteinase 3 (MMP3) in Preadipocytes/Stromal Vascular Cells From Nonobese Nondiabetic Versus Obese Nondiabetic Pima Indians

Analysis of 14 Candidate Genes for Diabetic Nephropathy on Chromosome 3q in European Populations: Strongest Evidence for Association With a Variant in the Promoter Region of the Adiponectin Gene

Brief Genetics Reports

No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians

Common Variants in the ENPP1 Gene Are Not Reproducibly Associated With Diabetes or Obesity

Islet Autoimmunity in Children With Down’s Syndrome

TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population : The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study

The HADHSC Gene Encoding Short-Chain l-3-Hydroxyacyl-CoA Dehydrogenase (SCHAD) and Type 2 Diabetes Susceptibility : The DAMAGE Study

Erratum

Erratum

This Issue

Current Issue

Expression of ATP-Insensitive K_ATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes

Poly(ADP-Ribose) Polymerase Inhibitors Ameliorate Nephropathy of Type 2 Diabetic Lepr^db/db Mice