Table of Contents

• Colin W. Hay and
• Kevin Docherty

Comparative Analysis of Insulin Gene Promoters: Implications for Diabetes Research

• Leentje Van Lommel,
• Kristel Janssens,
• Roel Quintens,
• Katsura Tsukamoto,
• Dirk Vander Mierde,
• Katleen Lemaire,
• Carl Denef,
• Jean-Christophe Jonas,
• Geert Martens,
• Daniel Pipeleers,
• and Frans C. Schuit

Probe-Independent and Direct Quantification of Insulin mRNA and Growth Hormone mRNA in Enriched Cell Preparations

• Emmani B.M. Nascimento,
• Mariann Fodor,
• Gerard C.M. van der Zon,
• Ingrid M. Jazet,
• A. Edo Meinders,
• Peter J. Voshol,
• Ronald Vlasblom,
• Bart Baan,
• Jürgen Eckel,
• J. Antonie Maassen,
• Michaela Diamant,
• and D. Margriet Ouwens

Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats

• Dervla O’Malley,
• Frank Reimann,
• Anna K. Simpson,
• and Fiona M. Gribble

Sodium-Coupled Glucose Cotransporters Contribute to Hypothalamic Glucose Sensing

• Qiwei Wu,
• Melissa Kazantzis,
• Holger Doege,
• Angelica M. Ortegon,
• Bernice Tsang,
• Alaric Falcon,
• and Andreas Stahl

Fatty Acid Transport Protein 1 Is Required for Nonshivering Thermogenesis in Brown Adipose Tissue

• Diana L. Williams,
• Denis G. Baskin,
• and Michael W. Schwartz

Leptin Regulation of the Anorexic Response to Glucagon-Like Peptide-1 Receptor Stimulation

• Zhi Hua Huang,
• Catherine A. Reardon,
• and Theodore Mazzone

Endogenous ApoE Expression Modulates Adipocyte Triglyceride Content and Turnover

• Christian Doyon,
• Raphaël G. Denis,
• Elena-Dana Baraboi,
• Pierre Samson,
• Josée Lalonde,
• Yves Deshaies,
• and Denis Richard

Effects of Rimonabant (SR141716) on Fasting-Induced Hypothalamic-Pituitary-Adrenal Axis and Neuronal Activation in Lean and Obese Zucker Rats

• Juan C. Molero,
• Nigel Turner,
• Christine B.F. Thien,
• Wallace Y. Langdon,
• David E. James,
• and Gregory J. Cooney

Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action

• Nathan E. Wolins,
• Benjamin K. Quaynor,
• James R. Skinner,
• Anatoly Tzekov,
• Michelle A. Croce,
• Matthew C. Gropler,
• Vijayalakshmi Varma,
• Aiwei Yao-Borengasser,
• Neda Rasouli,
• Philip A. Kern,
• Brian N. Finck,
• and Perry E. Bickel

OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization

• Jun Xu,
• W.N. Paul Lee,
• Jack Phan,
• Mohammed F. Saad,
• Karen Reue,
• and Irwin J. Kurland

Lipin Deficiency Impairs Diurnal Metabolic Fuel Switching

• Nicole A. Sherry,
• Jake A. Kushner,
• Mariela Glandt,
• Tadahiro Kitamura,
• Anne-Marie B. Brillantes,
• and Kevan C. Herold

Effects of Autoimmunity and Immune Therapy on β-Cell Turnover in Type 1 Diabetes

• Alba Casellas,
• Ariana Salavert,
• Judith Agudo,
• Eduard Ayuso,
• Veronica Jimenez,
• Marta Moya,
• Sergio Muñoz,
• Sylvie Franckhauser,
• and Fatima Bosch

Expression of IGF-I in Pancreatic Islets Prevents Lymphocytic Infiltration and Protects Mice From Type 1 Diabetes

• Dengping Yin,
• Jing Tao,
• David D. Lee,
• Jikun Shen,
• Manami Hara,
• James Lopez,
• Andrey Kuznetsov,
• Louis H. Philipson,
• and Anita S. Chong

Recovery of Islet β-Cell Function in Streptozotocin- Induced Diabetic Mice: An Indirect Role for the Spleen

• Huriya Beyan,
• Martin R. Goodier,
• Niga S. Nawroly,
• Mohammed I. Hawa,
• Stephen A. Bustin,
• William B. Ogunkolade,
• Marco Londei,
• Nasim Yousaf,
• and R. David G. Leslie

Altered Monocyte Cyclooxygenase Response to Lipopolysaccharide in Type 1 Diabetes

• Minna Tiittanen,
• Johanna T. Huupponen,
• Mikael Knip,
• and Outi Vaarala

Insulin Treatment in Patients With Type 1 Diabetes Induces Upregulation of Regulatory T-Cell Markers in Peripheral Blood Mononuclear Cells Stimulated With Insulin In Vitro

• Xinhui Ge,
• Jon D. Piganelli,
• Hubert M. Tse,
• Suzanne Bertera,
• Clayton E. Mathews,
• Massimo Trucco,
• Li Wen,
• and William A. Rudert

Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility

• Elizabeth Tweedie,
• Isabella Artner,
• Laura Crawford,
• Greg Poffenberger,
• Bernard Thorens,
• Roland Stein,
• Alvin C. Powers,
• and Maureen Gannon

Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of β-Cells

• Irene Cozar-Castellano,
• Marcia Haught,
• and Andrew F. Stewart

The Cell Cycle Inhibitory Protein p21^cip Is Not Essential for Maintaining β-Cell Cycle Arrest or β-Cell Function In Vivo

• Anne-Dominique Lajoix,
• Stéphanie Badiou,
• Sylvie Péraldi-Roux,
• Thierry Chardès,
• Samuel Dietz,
• Cindy Aknin,
• Florence Tribillac,
• Pierre Petit,
• and René Gross

Protein Inhibitor of Neuronal Nitric Oxide Synthase (PIN) Is a New Regulator of Glucose-Induced Insulin Secretion

• Mina Peshavaria,
• Brooke L. Larmie,
• James Lausier,
• Basanthi Satish,
• Aida Habibovic,
• Violet Roskens,
• Kyla LaRock,
• Brian Everill,
• Jack L. Leahy,
• and Thomas L. Jetton

Regulation of Pancreatic β-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse

• Päivi J. Miettinen,
• Jarkko Ustinov,
• Päivi Ormio,
• Ru Gao,
• Jaan Palgi,
• Elina Hakonen,
• Lisa Juntti-Berggren,
• Per-Olof Berggren,
• and Timo Otonkoski

Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth

• Heidi Sørensen,
• Maria Sörhede Winzell,
• Christian L. Brand,
• Keld Fosgerau,
• Richard W. Gelling,
• Erica Nishimura,
• and Bo Ahren

Glucagon Receptor Knockout Mice Display Increased Insulin Sensitivity and Impaired β-Cell Function

• Jean-Claude Henquin,
• Denis Dufrane,
• and Myriam Nenquin

Nutrient Control of Insulin Secretion in Isolated Normal Human Islets

• Guy Las,
• Nina Mayorek,
• Kobie Dickstein,
• and Jacob Bar-Tana

Modulation of Insulin Secretion by Fatty Acyl Analogs

• Katsuya Dezaki,
• Hideyuki Sone,
• Masaru Koizumi,
• Masanori Nakata,
• Masafumi Kakei,
• Hideo Nagai,
• Hiroshi Hosoda,
• Kenji Kangawa,
• and Toshihiko Yada

Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance

• Charlotte Granhall,
• Anders H. Rosengren,
• Erik Renström,
• and Holger Luthman

Separately Inherited Defects in Insulin Exocytosis and β-Cell Glucose Metabolism Contribute to Type 2 Diabetes

• Mark J. Holness,
• Gemma K. Greenwood,
• Nicholas D. Smith,
• and Mary C. Sugden

Peroxisome Proliferator–Activated Receptor-α and Glucocorticoids Interactively Regulate Insulin Secretion During Pregnancy

• Ian R. Sweet and
• Merle Gilbert

Contribution of Calcium Influx in Mediating Glucose-Stimulated Oxygen Consumption in Pancreatic Islets

• Latif Rachdi,
• Norman Balcazar,
• Lynda Elghazi,
• Daniel J. Barker,
• Irina Krits,
• Hiroaki Kiyokawa,
• and Ernesto Bernal-Mizrachi

Differential Effects of p27 in Regulation of β-Cell Mass During Development, Neonatal Period, and Adult Life

• Yan W. Asmann,
• Craig S. Stump,
• Kevin R. Short,
• Jill M. Coenen-Schimke,
• ZengKui Guo,
• Maureen L. Bigelow,
• and K. Sreekumaran Nair

Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia

• Renate E. van Genugten,
• Kristina M. Utzschneider,
• Jenny Tong,
• Fernando Gerchman,
• Sakeneh Zraika,
• Jayalakshmi Udayasankar,
• Edward J. Boyko,
• Wilfred Y. Fujimoto,
• Steven E. Kahn,
• and and the American Diabetes Association GENNID Study Group

Effects of Sex and Hormone Replacement Therapy Use on the Prevalence of Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Family History of Type 2 Diabetes

• Gerlies Bock,
• Chiara Dalla Man,
• Marco Campioni,
• Elizabeth Chittilapilly,
• Rita Basu,
• Gianna Toffolo,
• Claudio Cobelli,
• and Robert Rizza

Pathogenesis of Pre-Diabetes: Mechanisms of Fasting and Postprandial Hyperglycemia in People With Impaired Fasting Glucose and/or Impaired Glucose Tolerance

• Buffie J. Clodfelder-Miller,
• Anna A. Zmijewska,
• Gail V.W. Johnson,
• and Richard S. Jope

Tau Is Hyperphosphorylated at Multiple Sites in Mouse Brain In Vivo After Streptozotocin-Induced Insulin Deficiency

• Rakeshwar S. Guleria,
• Jing Pan,
• Donald DiPette,
• and Ugra S. Singh

Hyperglycemia Inhibits Retinoic Acid–Induced Activation of Rac1, Prevents Differentiation of Cortical Neurons, and Causes Oxidative Stress in a Rat Model of Diabetic Pregnancy

• Viktor R. Drel,
• Nazar Mashtalir,
• Olga Ilnytska,
• Jeho Shin,
• Fei Li,
• Valeriy V. Lyzogubov,
• and Irina G. Obrosova

The Leptin-Deficient (ob/ob) Mouse: A New Animal Model of Peripheral Neuropathy of Type 2 Diabetes and Obesity

• Frederik Persson,
• Peter Rossing,
• Peter Hovind,
• Coen D.A. Stehouwer,
• Casper Schalkwijk,
• Lise Tarnow,
• and Hans-Henrik Parving

Irbesartan Treatment Reduces Biomarkers of Inflammatory Activity in Patients With Type 2 Diabetes and Microalbuminuria: An IRMA 2 Substudy

• Patricia A. Cleary,
• Trevor J. Orchard,
• Saul Genuth,
• Nathan D. Wong,
• Robert Detrano,
• Jye-Yu C. Backlund,
• Bernard Zinman,
• Alan Jacobson,
• Wanjie Sun,
• John M. Lachin,
• and David M. Nathan

The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

• R. Neil A. Black,
• Michelle Spence,
• Ross O. McMahon,
• Geraldine J. Cuskelly,
• Cieran N. Ennis,
• David R. McCance,
• Ian S. Young,
• Patrick M. Bell,
• and Steven J. Hunter

Effect of Eucaloric High- and Low-Sucrose Diets With Identical Macronutrient Profile on Insulin Resistance and Vascular Risk: A Randomized Controlled Trial

• Todd E. Fox,
• Xianlin Han,
• Samuel Kelly,
• Alfred H. Merrill, Jr.,
• Rex E. Martin,
• Robert E. Anderson,
• Thomas W. Gardner,
• and Mark Kester

Diabetes Alters Sphingolipid Metabolism in the Retina: A Potential Mechanism of Cell Death in Diabetic Retinopathy

• Hideki Kamiya,
• Weixian Zhang,
• Karin Ekberg,
• John Wahren,
• and Anders A.F. Sima

C-Peptide Reverses Nociceptive Neuropathy in Type 1 Diabetes

• Randy S. Sprague,
• Alan H. Stephenson,
• Elizabeth A. Bowles,
• Madelyn S. Stumpf,
• and Andrew J. Lonigro

Reduced Expression of G_i in Erythrocytes of Humans With Type 2 Diabetes Is Associated With Impairment of Both cAMP Generation and ATP Release

• Garry M. Steil,
• Kerstin Rebrin,
• Christine Darwin,
• Farzam Hariri,
• and Mohammed F. Saad

Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes

• Maria A. Potenza,
• Flora L. Marasciulo,
• Mariela Tarquinio,
• Michael J. Quon,
• and Monica Montagnani

Treatment of Spontaneously Hypertensive Rats With Rosiglitazone and/or Enalapril Restores Balance Between Vasodilator and Vasoconstrictor Actions of Insulin With Simultaneous Improvement in Hypertension and Insulin Resistance

• Dale S. Edgerton,
• Alan D. Cherrington,
• Phillip Williams,
• Doss W. Neal,
• Melanie Scott,
• Larry Bowen,
• Warren Wilson,
• Charles H. Hobbs,
• Chet Leach,
• Mei-chang Kuo,
• and Thomas R. Strack

Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo

• Jessica M. Fuller,
• Anne E. Kwitek,
• Tyson J. Hawkins,
• Daniel H. Moralejo,
• Wen Lu,
• Terry D. Tupling,
• Armand J. MacMurray,
• Gretta Borchardt,
• Michael Hasinoff,
• and Åke Lernmark

Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats

• Grzegorz Placha,
• G. David Poznik,
• Jonathon Dunn,
• Adam Smiles,
• Bozena Krolewski,
• Timothy Glew,
• Sobha Puppala,
• Jennifer Schneider,
• John J. Rogus,
• Stephen S. Rich,
• Ravindranath Duggirala,
• James H. Warram,
• and Andrzej S. Krolewski

A Genome-Wide Linkage Scan for Genes Controlling Variation in Renal Function Estimated by Serum Cystatin C Levels in Extended Families With Type 2 Diabetes

• Evgueni A. Ivakine,
• Steven M. Mortin-Toth,
• Omid M. Gulban,
• Aneta Valova,
• Angelo Canty,
• Christopher Scott,
• and Jayne S. Danska

The Idd4 Locus Displays Sex-Specific Epistatic Effects on Type 1 Diabetes Susceptibility in Nonobese Diabetic Mice

• Juliette Gray,
• Giles S.H. Yeo,
• James J. Cox,
• Jenny Morton,
• Anna-Lynne R. Adlam,
• Julia M. Keogh,
• Jack A. Yanovski,
• Areeg El Gharbawy,
• Joan C. Han,
• Y.C. Loraine Tung,
• John R. Hodges,
• F. Lucy Raymond,
• Stephen O’Rahilly,
• and I. Sadaf Farooqi

Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene

• Jose C. Florez,
• Richa Saxena,
• Wendy Winckler,
• Noël P. Burtt,
• Peter Almgren,
• Kristina Bengtsson Boström,
• Tiinamaija Tuomi,
• Daniel Gaudet,
• Kristin G. Ardlie,
• Mark J. Daly,
• David Altshuler,
• Joel N. Hirschhorn,
• and Leif Groop

The Krüppel-Like Factor 11 (KLF11) Q62R Polymorphism Is Not Associated With Type 2 Diabetes in 8,676 People

• Yan Guo,
• Michael Traurig,
• Lijun Ma,
• Sayuko Kobes,
• Inge Harper,
• Aniello M. Infante,
• Clifton Bogardus,
• Leslie J. Baier,
• and Michal Prochazka

CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians

• Julian Munoz,
• Kerry H. Lok,
• Barbara A. Gower,
• Jose R. Fernandez,
• Gary R. Hunter,
• Cristina Lara-Castro,
• Maria De Luca,
• and W. Timothy Garvey

Polymorphism in the Transcription Factor 7-Like 2 (TCF7L2) Gene Is Associated With Reduced Insulin Secretion in Nondiabetic Women

• Jun Xu,
• Lori Gowen,
• Christian Raphalides,
• Katrina K. Hoyer,
• Jason G. Weinger,
• Mathilde Renard,
• Joshua J. Troke,
• Bhavapriya Vaitheesyaran,
• W.N. Paul Lee,
• Mohammed F. Saad,
• Mark W. Sleeman,
• Michael A. Teitell,
• and Irwin J. Kurland

Decreased Hepatic Futile Cycling Compensates for Increased Glucose Disposal in the Pten Heterodeficient Mouse

Errata

Errata