Table of Contents

• Catherine S. Lee,
• Diva D. De León,
• Klaus H. Kaestner,
• and Doris A. Stoffers

Regeneration of Pancreatic Islets After Partial Pancreatectomy in Mice Does Not Involve the Reactivation of Neurogenin-3

• Sylvie Franckhauser,
• Sergio Muñoz,
• Ivet Elias,
• Tura Ferre,
• and Fatima Bosch

Adipose Overexpression of Phosphoenolpyruvate Carboxykinase Leads to High Susceptibility to Diet-Induced Insulin Resistance and Obesity

• Myriam Aouadi,
• Kathiane Laurent,
• Matthieu Prot,
• Yannick Le Marchand-Brustel,
• Bernard Binétruy,
• and Frédéric Bost

Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages

• Justin Y. Jeon,
• Richard L. Bradley,
• Efi G. Kokkotou,
• Francis E. Marino,
• Xiaomei Wang,
• Pavlos Pissios,
• and Eleftheria Maratos-Flier

MCH^−/− Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance

• Jalal Taneera,
• Anders Rosengren,
• Erik Renstrom,
• Jens M. Nygren,
• Palle Serup,
• Patrik Rorsman,
• and Sten Eirik W. Jacobsen

Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic β-Cell Fate

• Isabella Artner,
• John Le Lay,
• Yan Hang,
• Lynda Elghazi,
• Jonathan C. Schisler,
• Eva Henderson,
• Beatriz Sosa-Pineda,
• and Roland Stein

MafB: An Activator of the Glucagon Gene Expressed in Developing Islet α- and β-Cells

• Nils Wierup,
• Maria Björkqvist,
• Michael J. Kuhar,
• Hindrik Mulder,
• and Frank Sundler

CART Regulates Islet Hormone Secretion and Is Expressed in the β-Cells of Type 2 Diabetic Rats

• Gabrielle G.M. Pinkse,
• Wendy P. Bouwman,
• Reshma Jiawan-Lalai,
• O.T. Terpstra,
• Jan A. Bruijn,
• and Emile de Heer

Integrin Signaling via RGD Peptides and Anti-β1 Antibodies Confers Resistance to Apoptosis in Islets of Langerhans

• Szabolcs Fatrai,
• Lynda Elghazi,
• Norman Balcazar,
• Corentin Cras-Méneur,
• Irina Krits,
• Hiroaki Kiyokawa,
• and Ernesto Bernal-Mizrachi

Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity

• Claes-Goran Ostenson,
• Herbert Gaisano,
• Laura Sheu,
• Annika Tibell,
• and Tamas Bartfai

Impaired Gene and Protein Expression of Exocytotic Soluble N-Ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients

• Jean-Claude Henquin,
• Myriam Nenquin,
• Patrick Stiernet,
• and Bo Ahren

In Vivo and In Vitro Glucose-Induced Biphasic Insulin Secretion in the Mouse: Pattern and Role of Cytoplasmic Ca²⁺ and Amplification Signals in β-Cells

• Gunther Schmidt,
• Francine Sirois,
• Younes Anini,
• Lisa M. Kauri,
• Charles Gyamera-Acheampong,
• Eckart Fleck,
• Fraser W. Scott,
• Michel Chrétien,
• and Majambu Mbikay

Differences of Pancreatic Expression of 7B2 Between C57BL/6J and C3H/HeJ Mice and Genetic Polymorphisms at its locus (Sgne1)

• Gail Musen,
• In Kyoon Lyoo,
• Caitlin R. Sparks,
• Katie Weinger,
• Jaeuk Hwang,
• Christopher M. Ryan,
• David C. Jimerson,
• John Hennen,
• Perry F. Renshaw,
• and Alan M. Jacobson

Effects of Type 1 Diabetes on Gray Matter Density as Measured by Voxel-Based Morphometry

• Alette M. Wessels,
• Serge A.R.B. Rombouts,
• Suat Simsek,
• Joost P.A. Kuijer,
• Piet J. Kostense,
• Frederik Barkhof,
• Philip Scheltens,
• Frank J. Snoek,
• and Robert J. Heine

Microvascular Disease in Type 1 Diabetes Alters Brain Activation: A Functional Magnetic Resonance Imaging Study

• Paul W. Franks,
• Helen C. Looker,
• Sayuko Kobes,
• Leslie Touger,
• P. Antonio Tataranni,
• Robert L. Hanson,
• and William C. Knowler

Gestational Glucose Tolerance and Risk of Type 2 Diabetes in Young Pima Indian Offspring

• Ole-Jakob How,
• Ellen Aasum,
• David L. Severson,
• W.Y. Anna Chan,
• M. Faadiel Essop,
• and Terje S. Larsen

Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice

• Lawrence J. Coppey,
• Eric P. Davidson,
• Thomas W. Rinehart,
• Jill S. Gellett,
• Christine L. Oltman,
• Donald D. Lund,
• and Mark A. Yorek

ACE Inhibitor or Angiotensin II Receptor Antagonist Attenuates Diabetic Neuropathy in Streptozotocin-Induced Diabetic Rats

• Marianna Muranyi,
• Chaonan Ding,
• QingPing He,
• Yanling Lin,
• and Ping-An Li

Streptozotocin-Induced Diabetes Causes Astrocyte Death After Ischemia and Reperfusion Injury

• Reiko Inagi,
• Yasuhiko Yamamoto,
• Masaomi Nangaku,
• Nobuteru Usuda,
• Hiroshi Okamato,
• Kiyoshi Kurokawa,
• Charles van Ypersele de Strihou,
• Hiroshi Yamamoto,
• and Toshio Miyata

A Severe Diabetic Nephropathy Model With Early Development of Nodule-Like Lesions Induced by Megsin Overexpression in RAGE/iNOS Transgenic Mice

• Michael J. Haas,
• Mohamad H. Horani,
• Shant A. Parseghian,
• and Arshag D. Mooradian

Statins Prevent Dextrose-Induced Endothelial Barrier Dysfunction, Possibly Through Inhibition of Superoxide Formation

• Max Nieuwdorp,
• Timon W. van Haeften,
• Mirella C.L.G. Gouverneur,
• Hans L. Mooij,
• Miriam H.P. van Lieshout,
• Marcel Levi,
• Joost C.M. Meijers,
• Frits Holleman,
• Joost B.L. Hoekstra,
• Hans Vink,
• John J.P. Kastelein,
• and Erik S.G. Stroes

Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo

• Hesham A. Al-Mashat,
• Suneel Kandru,
• Rongkun Liu,
• Yugal Behl,
• Tesfahun Desta,
• and Dana T. Graves

Diabetes Enhances mRNA Levels of Proapoptotic Genes and Caspase Activity, Which Contribute to Impaired Healing

• Bradley J. Davis,
• Zhonglin Xie,
• Benoit Viollet,
• and Ming-Hui Zou

Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase

• M. Kamran Ikram,
• Joop A.M.J.L. Janssen,
• Anna M.E. Roos,
• Ingrid Rietveld,
• Jacqueline C.M. Witteman,
• Monique M.B. Breteler,
• Albert Hofman,
• Cornelia M. van Duijn,
• and Paulus T.V.M. de Jong

Retinal Vessel Diameters and Risk of Impaired Fasting Glucose or Diabetes: The Rotterdam Study

• Kwan Yi Chu,
• Tung Lau,
• Per-Ola Carlsson,
• and Po Sing Leung

Angiotensin II Type 1 Receptor Blockade Improves β-Cell Function and Glucose Tolerance in a Mouse Model of Type 2 Diabetes

• Riikka Lautamäki,
• K.E. Juhani Airaksinen,
• Marko Seppänen,
• Jyri Toikka,
• Risto Härkönen,
• Matti Luotolahti,
• Ronald Borra,
• Jan Sundell,
• Juhani Knuuti,
• and Pirjo Nuutila

Insulin Improves Myocardial Blood Flow in Patients With Type 2 Diabetes and Coronary Artery Disease

• Anny H. Xiang,
• Ruth K. Peters,
• Siri L. Kjos,
• Aura Marroquin,
• Jose Goico,
• Cesar Ochoa,
• Miwa Kawakubo,
• and Thomas A. Buchanan

Effect of Pioglitazone on Pancreatic β-Cell Function and Diabetes Risk in Hispanic Women With Prior Gestational Diabetes

• Iris M. Heid,
• Stefanie A. Wagner,
• Henning Gohlke,
• Bernhard Iglseder,
• Jakob C. Mueller,
• Paula Cip,
• Günther Ladurner,
• Raphael Reiter,
• Andreas Stadlmayr,
• Vitolds Mackevics,
• Thomas Illig,
• Florian Kronenberg,
• and Bernhard Paulweber

Genetic Architecture of the APM1 Gene and Its Influence on Adiponectin Plasma Levels and Parameters of the Metabolic Syndrome in 1,727 Healthy Caucasians

• Jessica G. Woo,
• Lawrence M. Dolan,
• Ranjan Deka,
• Ritesh D. Kaushal,
• Yayun Shen,
• Prodipto Pal,
• Stephen R. Daniels,
• and Lisa J. Martin

Interactions Between Noncontiguous Haplotypes in the Adiponectin Gene ACDC Are Associated With Plasma Adiponectin

• James B. Meigs,
• Christopher J. O’Donnell,
• Geoffrey H. Tofler,
• Emelia J. Benjamin,
• Caroline S. Fox,
• Izabela Lipinska,
• David M. Nathan,
• Lisa M. Sullivan,
• Ralph B. D’Agostino,
• and Peter W.F. Wilson

Hemostatic Markers of Endothelial Dysfunction and Risk of Incident Type 2 Diabetes: The Framingham Offspring Study

• Marie Lundholm,
• Vinicius Motta,
• Anna Löfgren-Burström,
• Nadia Duarte,
• Marie-Louise Bergman,
• Sofia Mayans,
• and Dan Holmberg

Defective Induction of CTLA-4 in the NOD Mouse Is Controlled by the NOD Allele of Idd3/IL-2 and a Novel Locus (Ctex) Telomeric on Chromosome 1

• Ronit Shiri-Sverdlov,
• Anne Custers,
• Jana V. van Vliet-Ostaptchouk,
• Patrick J.J. van Gorp,
• Patrick J. Lindsey,
• Jonathan H.O. van Tilburg,
• Sasha Zhernakova,
• Edith J.M. Feskens,
• Daphne L. van der A,
• Martijn E.T. Dollé,
• Timon W. van Haeften,
• Bobby P.C. Koeleman,
• Marten H. Hofker,
• and Cisca Wijmenga

Identification of TUB as a Novel Candidate Gene Influencing Body Weight in Humans

• Nabila Bouatia-Naji,
• David Meyre,
• Stéphane Lobbens,
• Karin Séron,
• Frédéric Fumeron,
• Beverley Balkau,
• Barbara Heude,
• Béatrice Jouret,
• Philipp E. Scherer,
• Christian Dina,
• Jacques Weill,
• and Philippe Froguel

ACDC/Adiponectin Polymorphisms Are Associated With Severe Childhood and Adult Obesity

• Ping An,
• Barry I. Freedman,
• Stephen S. Rich,
• Stephen A. Mandel,
• Donna K. Arnett,
• Richard H. Myers,
• Yii-Der I. Chen,
• Steven C. Hunt,
• and D.C. Rao

Quantitative Trait Loci on Chromosome 8q24 for Pancreatic β-Cell Function and 7q11 for Insulin Sensitivity in Obese Nondiabetic White and Black Families: Evidence From Genome-Wide Linkage Scans in the NHLBI Hypertension Genetic Epidemiology Network (HyperGEN) Study

• Jeffrey S. Szeszko,
• Joanna M.M. Howson,
• Jason D. Cooper,
• Neil M. Walker,
• Rebecca C.J. Twells,
• Helen E. Stevens,
• Sarah L. Nutland,
• and John A. Todd

Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1 Diabetes and Hardy-Weinberg Equilibrium Testing

• Julio E. Ayala,
• Deanna P. Bracy,
• Owen P. McGuinness,
• and David H. Wasserman

Considerations in the Design of Hyperinsulinemic-Euglycemic Clamps in the Conscious Mouse

• Martin Lévesque,
• Marta Santuré,
• Maryse Pitre,
• André Nadeau,
• and Hélène Bachelard

Cholinergic Involvement in Vascular and Glucoregulatory Actions of Insulin in Rats

• Anna Brackenridge,
• Ewan R. Pearson,
• Fariba Shojaee-Moradie,
• Andrew T. Hattersley,
• David Russell-Jones,
• and A. Margot Umpleby

Contrasting Insulin Sensitivity of Endogenous Glucose Production Rate in Subjects With Hepatocyte Nuclear Factor-1β and -1α Mutations

• Ling Kang,
• Ambrose A. Dunn-Meynell,
• Vanessa H. Routh,
• Larry D. Gaspers,
• Yasufumi Nagata,
• Teruyuki Nishimura,
• Junichi Eiki,
• Bei B. Zhang,
• and Barry E. Levin

Glucokinase Is a Critical Regulator of Ventromedial Hypothalamic Neuronal Glucosensing

• Monica Palmada,
• Christoph Boehmer,
• Ahmad Akel,
• Jeyaganesh Rajamanickam,
• Sankarganesh Jeyaraj,
• Konrad Keller,
• and Florian Lang

SGK1 Kinase Upregulates GLUT1 Activity and Plasma Membrane Expression

Erratum