Table of Contents

Obesity Studies

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- Lihong Huo,
- Harvey J. Grill,
- and Christian Bjørbæk
Divergent Regulation of Proopiomelanocortin Neurons by Leptin in the Nucleus of the Solitary Tract and in the Arcuate Hypothalamic Nucleus
Diabetes March 2006 55:567-573; doi:10.2337/diabetes.55.03.06.db05-1143
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- Juan C. Molero,
- Samuel G. Waring,
- Adrian Cooper,
- Nigel Turner,
- Ross Laybutt,
- Gregory J. Cooney,
- and David E. James
Casitas b-Lineage Lymphoma–Deficient Mice Are Protected Against High-Fat Diet–Induced Obesity and Insulin Resistance
Diabetes March 2006 55:708-715; doi:10.2337/diabetes.55.03.06.db05-0312
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- Yong-Woon Kim,
- Jong-Yeon Kim,
- Yong-Hoon Park,
- So-Young Park,
- Kyu-Chang Won,
- Kwang-Hae Choi,
- Jung-Yoon Huh,
- and Ki-Hak Moon
Metformin Restores Leptin Sensitivity in High-Fat–Fed Obese Rats With Leptin Resistance
Diabetes March 2006 55:716-724; doi:10.2337/diabetes.55.03.06.db05-0917
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- Mikael Bjursell,
- Anna-Karin Gerdin,
- Karolina Ploj,
- David Svensson,
- Lennart Svensson,
- Jan Oscarsson,
- Michael Snaith,
- Jan Törnell,
- and Mohammad Bohlooly-Y
Melanin-Concentrating Hormone Receptor 1 Deficiency Increases Insulin Sensitivity in Obese Leptin-Deficient Mice Without Affecting Body Weight
Diabetes March 2006 55:725-733; doi:10.2337/diabetes.55.03.06.db05-1302

Islet Studies

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- Wei Zhang,
- Lena Lilja,
- Slavena A. Mandic,
- Jesper Gromada,
- Kamille Smidt,
- Juliette Janson,
- Yoshimi Takai,
- Christina Bark,
- Per-Olof Berggren,
- and Björn Meister
Tomosyn Is Expressed in β-Cells and Negatively Regulates Insulin Exocytosis
Diabetes March 2006 55:574-581; doi:10.2337/diabetes.55.03.06.db05-0015
Select this article
- Bertrand Duvillié,
- Myriam Attali,
- Ali Bounacer,
- Philippe Ravassard,
- Annie Basmaciogullari,
- and Raphael Scharfmann
The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation
Diabetes March 2006 55:582-589; doi:10.2337/diabetes.55.03.06.db05-0839
Select this article
- Nasim Warwar,
- Suad Efendic,
- Claes-Göran Östenson,
- Esther P. Haber,
- Erol Cerasi,
- and Rafael Nesher
Dynamics of Glucose-Induced Localization of PKC Isoenzymes in Pancreatic β-Cells: Diabetes-Related Changes in the GK Rat
Diabetes March 2006 55:590-599; doi:10.2337/diabetes.55.03.06.db05-0001
Select this article
- Darren J. Michael,
- Robert A. Ritzel,
- Leena Haataja,
- and Robert H. Chow
Pancreatic β-Cells Secrete Insulin in Fast- and Slow-Release Forms
Diabetes March 2006 55:600-607; doi:10.2337/diabetes.55.03.06.db05-1054
Select this article
- Malini Laloraya,
- Abdoreza Davoodi-Semiromi,
- G. Pradeep Kumar,
- Marcia McDuffie,
- and Jin-Xiong She
Impaired Crkl Expression Contributes to the Defective DNA Binding of Stat5b in Nonobese Diabetic Mice
Diabetes March 2006 55:734-741; doi:10.2337/diabetes.55.03.06.db05-1059
Select this article
- Diana Z. Ye,
- Mei-Hui Tai,
- Katrina D. Linning,
- Csaba Szabo,
- and L. Karl Olson
MafA Expression and Insulin Promoter Activity Are Induced by Nicotinamide and Related Compounds in INS-1 Pancreatic β-Cells
Diabetes March 2006 55:742-750; doi:10.2337/diabetes.55.03.06.db05-0653

Pathophysiology

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- Laetitia Pereira,
- Jan Matthes,
- Iris Schuster,
- Héctor H. Valdivia,
- Stefan Herzig,
- Sylvain Richard,
- and Ana M. Gómez
Mechanisms of [Ca²⁺]_i Transient Decrease in Cardiomyopathy of db/db Type 2 Diabetic Mice
Diabetes March 2006 55:608-615; doi:10.2337/diabetes.55.03.06.db05-1284
Select this article
- Anne Corbould,
- Haiyan Zhao,
- Salida Mirzoeva,
- Fraser Aird,
- and Andrea Dunaif
Enhanced Mitogenic Signaling in Skeletal Muscle of Women With Polycystic Ovary Syndrome
Diabetes March 2006 55:751-759; doi:10.2337/diabetes.55.03.06.db05-0453
Select this article
- Apiradee Sriwijitkamol,
- Christine Christ-Roberts,
- Rachele Berria,
- Phyllis Eagan,
- Thongchai Pratipanawatr,
- Ralph A. DeFronzo,
- Lawrence J. Mandarino,
- and Nicolas Musi
Reduced Skeletal Muscle Inhibitor of κBβ Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training
Diabetes March 2006 55:760-767; doi:10.2337/diabetes.55.03.06.db05-0677
Select this article
- Jing Fang and
- Michael H. Alderman
Impact of the Increasing Burden of Diabetes on Acute Myocardial Infarction in New York City: 1990–2000
Diabetes March 2006 55:768-773; doi:10.2337/diabetes.55.03.06.db05-1196
Select this article
- Sridevi Devaraj,
- Nicole Glaser,
- Steve Griffen,
- Janice Wang-Polagruto,
- Eric Miguelino,
- and Ishwarlal Jialal
Increased Monocytic Activity and Biomarkers of Inflammation in Patients With Type 1 Diabetes
Diabetes March 2006 55:774-779; doi:10.2337/diabetes.55.03.06.db05-1417
Select this article
- Dominick J. Angiolillo,
- Antonio Fernandez-Ortiz,
- Esther Bernardo,
- Celia Ramírez,
- Manel Sabaté,
- Pilar Jimenez-Quevedo,
- Rosana Hernández,
- Raul Moreno,
- Javier Escaned,
- Fernando Alfonso,
- Camino Bañuelos,
- Marco A. Costa,
- Theodore A. Bass,
- and Carlos Macaya
Clopidogrel Withdrawal Is Associated With Proinflammatory and Prothrombotic Effects in Patients With Diabetes and Coronary Artery Disease
Diabetes March 2006 55:780-784; doi:10.2337/diabetes.55.03.06.db05-1394
Select this article
- Karim Bouzakri,
- Håkan K.R. Karlsson,
- Henrik Vestergaard,
- Sten Madsbad,
- Erik Christiansen,
- and Juleen R. Zierath
IRS-1 Serine Phosphorylation and Insulin Resistance in Skeletal Muscle From Pancreas Transplant Recipients
Diabetes March 2006 55:785-791; doi:10.2337/diabetes.55.03.06.db05-0796
Select this article
- Kristian Löbner,
- Annette Knopff,
- Andrea Baumgarten,
- Ulrike Mollenhauer,
- Sabine Marienfeld,
- Marta Garrido-Franco,
- Ezio Bonifacio,
- and Anette-G. Ziegler
Predictors of Postpartum Diabetes in Women With Gestational Diabetes Mellitus
Diabetes March 2006 55:792-797; doi:10.2337/diabetes.55.03.06.db05-0746

Complications

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- Bunpei Kakinoki,
- Sumito Sekimoto,
- Satoshi Yuki,
- Tetsuya Ohgami,
- Mikiko Sejima,
- Keiji Yamagami,
- and Ken-ichi Saito
Orally Active Neurotrophin-Enhancing Agent Protects Against Dysfunctions of the Peripheral Nerves in Hyperglycemic Animals
Diabetes March 2006 55:616-621; doi:10.2337/diabetes.55.03.06.db05-1091
Select this article
- Raffaele Marfella,
- Michele D’Amico,
- Katherine Esposito,
- Alfonso Baldi,
- Clara Di Filippo,
- Mario Siniscalchi,
- Ferndinando Carlo Sasso,
- Michele Portoghese,
- Francesca Cirillo,
- Federico Cacciapuoti,
- Ornella Carbonara,
- Basilio Crescenzi,
- Feliciano Baldi,
- Antonio Ceriello,
- Giovanni Francesco Nicoletti,
- Francesco D’Andrea,
- Mario Verza,
- Ludovico Coppola,
- Francesco Rossi,
- and Dario Giugliano
The Ubiquitin-Proteasome System and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Rosiglitazone Treatment
Diabetes March 2006 55:622-632; doi:10.2337/diabetes.55.03.06.db05-0832
Select this article
- Thomas Pannicke,
- Ianors Iandiev,
- Antje Wurm,
- Ortrud Uckermann,
- Franziska vom Hagen,
- Andreas Reichenbach,
- Peter Wiedemann,
- Hans-Peter Hammes,
- and Andreas Bringmann
Diabetes Alters Osmotic Swelling Characteristics and Membrane Conductance of Glial Cells in Rat Retina
Diabetes March 2006 55:633-639; doi:10.2337/diabetes.55.03.06.db05-1349
Select this article
- Xia Shen,
- Shirong Zheng,
- Naira S. Metreveli,
- and Paul N. Epstein
Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy
Diabetes March 2006 55:798-805; doi:10.2337/diabetes.55.03.06.db05-1039
Select this article
- Christer S. Andreassen,
- Johannes Jakobsen,
- and Henning Andersen
Muscle Weakness: A Progressive Late Complication in Diabetic Distal Symmetric Polyneuropathy
Diabetes March 2006 55:806-812; doi:10.2337/diabetes.55.03.06.db05-1237
Select this article
- Kit Guan,
- Chris Hudson,
- Tien Wong,
- Mila Kisilevsky,
- Ravi K. Nrusimhadevara,
- Wai Ching Lam,
- Mark Mandelcorn,
- Robert G. Devenyi,
- and John G. Flanagan
Retinal Hemodynamics in Early Diabetic Macular Edema
Diabetes March 2006 55:813-818; doi:10.2337/diabetes.55.03.06.db05-0937

Pharmacology & Therapeutics

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- Allison B. Goldfine,
- Sarah Crunkhorn,
- Maura Costello,
- Hiral Gami,
- Edwin J. Landaker,
- Michio Niinobe,
- Kazuaki Yoshikawa,
- David Lo,
- Amy Warren,
- Jose Jimenez-Chillaron,
- and Mary Elizabeth Patti
Necdin and E2F4 Are Modulated by Rosiglitazone Therapy in Diabetic Human Adipose and Muscle Tissue
Diabetes March 2006 55:640-650; doi:10.2337/diabetes.55.03.06.db05-1015
Select this article
- Juei-Tang Cheng,
- Ching-Chiu Huang,
- I-Min Liu,
- Thing-Fong Tzeng,
- and Chih Jen Chang
Novel Mechanism for Plasma Glucose–Lowering Action of Metformin in Streptozotocin-Induced Diabetic Rats
Diabetes March 2006 55:819-825; doi:10.2337/diabetes.55.03.06.db05-0934

Genetics

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- Kathryn P. Burdon,
- Jennifer L. Bento,
- Carl D. Langefeld,
- Joel K. Campbell,
- J. Jeffery Carr,
- Lynne M. Wagenknecht,
- David M. Herrington,
- Barry I. Freedman,
- Stephen S. Rich,
- and Donald W. Bowden
Association of Protein Tyrosine Phosphatase-N1 Polymorphisms With Coronary Calcified Plaque in the Diabetes Heart Study
Diabetes March 2006 55:651-658; doi:10.2337/diabetes.55.03.06.db05-0058
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- Lovisa E. Johansson,
- Johan Hoffstedt,
- Hemang Parikh,
- Emma Carlsson,
- Martin Wabitsch,
- Anne-Greth Bondeson,
- Jan Hedenbro,
- Hans Tornqvist,
- Leif Groop,
- and Martin Ridderstråle
Variation in the Adiponutrin Gene Influences Its Expression and Associates With Obesity
Diabetes March 2006 55:826-833; doi:10.2337/diabetes.55.03.06.db05-1075
Select this article
- John E. Hokanson,
- Gregory L. Kinney,
- Suzanne Cheng,
- Henry A. Erlich,
- Adam Kretowski,
- and Marian Rewers
Susceptibility to Type 1 Diabetes Is Associated With ApoCIII Gene Haplotypes
Diabetes March 2006 55:834-838; doi:10.2337/diabetes.55.03.06.db05-1380

Metabolism

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- Preeti Kishore,
- Ilan Gabriely,
- Min-Hui Cui,
- Joseph Di Vito,
- Srikanth Gajavelli,
- Jong-Hee Hwang,
- and Harry Shamoon
Role of Hepatic Glycogen Breakdown in Defective Counterregulation of Hypoglycemia in Intensively Treated Type 1 Diabetes
Diabetes March 2006 55:659-666; doi:10.2337/diabetes.55.03.06.db05-0849
Select this article
- Rita Basu,
- Ravinder Singh,
- Ananda Basu,
- C.M. Johnson,
- and Robert A. Rizza
Effect of Nutrient Ingestion on Total-Body and Splanchnic Cortisol Production in Humans
Diabetes March 2006 55:667-674; doi:10.2337/diabetes.55.03.06.db05-1335
Select this article
- Stéphanie Chevalier,
- Shawn C. Burgess,
- Craig R. Malloy,
- Réjeanne Gougeon,
- Errol B. Marliss,
- and José A. Morais
The Greater Contribution of Gluconeogenesis to Glucose Production in Obesity Is Related to Increased Whole-Body Protein Catabolism
Diabetes March 2006 55:675-681; doi:10.2337/diabetes.55.03.06.db05-1117

Signal Transduction

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- Dana S. Hutchinson and
- Tore Bengtsson
AMP-Activated Protein Kinase Activation by Adrenoceptors in L6 Skeletal Muscle Cells: Mediation by α₁-Adrenoceptors Causing Glucose Uptake
Diabetes March 2006 55:682-690; doi:10.2337/diabetes.55.03.06.db05-0901
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- Keiko Naruse,
- Christian Rask-Madsen,
- Noriko Takahara,
- Sung-woo Ha,
- Kiyoshi Suzuma,
- Kerrie J. Way,
- Judith R.C. Jacobs,
- Allen C. Clermont,
- Kohjiro Ueki,
- Yuzuru Ohshiro,
- Junqing Zhang,
- Allison B. Goldfine,
- and George L. King
Activation of Vascular Protein Kinase C-β Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance
Diabetes March 2006 55:691-698; doi:10.2337/diabetes.55.03.06.db05-0771
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- Hang Shi,
- Belinda Cave,
- Karen Inouye,
- Christian Bjørbæk,
- and Jeffrey S. Flier
Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance
Diabetes March 2006 55:699-707; doi:10.2337/diabetes.55.03.06.db05-0841

Brief Genetics Reports

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- Farook Thameem,
- Vidya S. Farook,
- Clifton Bogardus,
- and Michal Prochazka
Association of Amino Acid Variants in the Activating Transcription Factor 6 Gene (ATF6) on 1q21-q23 With Type 2 Diabetes in Pima Indians
Diabetes March 2006 55:839-842; doi:10.2337/diabetes.55.03.06.db05-1002
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- Jae Hyeon Kim,
- Hyoung Doo Shin,
- Byung Lae Park,
- Min Kyong Moon,
- Young Min Cho,
- Young Hwan Hwang,
- Kook Whan Oh,
- Seong Yeon Kim,
- Hong Kyu Lee,
- Curie Ahn,
- and Kyong Soo Park
SLC12A3 (Solute Carrier Family 12 Member [Sodium/Chloride] 3) Polymorphisms Are Associated With End-Stage Renal Disease in Diabetic Nephropathy
Diabetes March 2006 55:843-848; doi:10.2337/diabetes.55.03.06.db05-1013
Select this article
- Maria W. Sun,
- Jennifer Y. Lee,
- Paul I.W. de Bakker,
- Noël P. Burtt,
- Peter Almgren,
- Lennart Råstam,
- Tiinamaija Tuomi,
- Daniel Gaudet,
- Mark J. Daly,
- Joel N. Hirschhorn,
- David Altshuler,
- Leif Groop,
- and Jose C. Florez
Haplotype Structures and Large-Scale Association Testing of the 5′ AMP-Activated Protein Kinase Genes PRKAA2, PRKAB1, and PRKAB2 With Type 2 Diabetes
Diabetes March 2006 55:849-855; doi:10.2337/diabetes.55.03.06.db05-1418
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- Martine Vaxillaire,
- Aurélie Dechaume,
- Valérie Vasseur-Delannoy,
- Saida Lahmidi,
- Vincent Vatin,
- Frédéric Leprêtre,
- Philippe Boutin,
- Serge Hercberg,
- Guillaume Charpentier,
- Christian Dina,
- and Philippe Froguel
Genetic Analysis of ADIPOR1 and ADIPOR2 Candidate Polymorphisms for Type 2 Diabetes in the Caucasian Population
Diabetes March 2006 55:856-861; doi:10.2337/diabetes.55.03.06.db05-0665

Errata

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Erratum
Diabetes March 2006 55:862
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Diabetes March 2006 55:862
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Erratum
Diabetes March 2006 55:862

Diabetes

Obesity Studies

Divergent Regulation of Proopiomelanocortin Neurons by Leptin in the Nucleus of the Solitary Tract and in the Arcuate Hypothalamic Nucleus

Casitas b-Lineage Lymphoma–Deficient Mice Are Protected Against High-Fat Diet–Induced Obesity and Insulin Resistance

Metformin Restores Leptin Sensitivity in High-Fat–Fed Obese Rats With Leptin Resistance

Melanin-Concentrating Hormone Receptor 1 Deficiency Increases Insulin Sensitivity in Obese Leptin-Deficient Mice Without Affecting Body Weight

Islet Studies

Tomosyn Is Expressed in β-Cells and Negatively Regulates Insulin Exocytosis

The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation

Dynamics of Glucose-Induced Localization of PKC Isoenzymes in Pancreatic β-Cells: Diabetes-Related Changes in the GK Rat

Pancreatic β-Cells Secrete Insulin in Fast- and Slow-Release Forms

Impaired Crkl Expression Contributes to the Defective DNA Binding of Stat5b in Nonobese Diabetic Mice

MafA Expression and Insulin Promoter Activity Are Induced by Nicotinamide and Related Compounds in INS-1 Pancreatic β-Cells

Pathophysiology

Mechanisms of [Ca2+]i Transient Decrease in Cardiomyopathy of db/db Type 2 Diabetic Mice

Enhanced Mitogenic Signaling in Skeletal Muscle of Women With Polycystic Ovary Syndrome

Reduced Skeletal Muscle Inhibitor of κBβ Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training

Impact of the Increasing Burden of Diabetes on Acute Myocardial Infarction in New York City: 1990–2000

Increased Monocytic Activity and Biomarkers of Inflammation in Patients With Type 1 Diabetes

Clopidogrel Withdrawal Is Associated With Proinflammatory and Prothrombotic Effects in Patients With Diabetes and Coronary Artery Disease

IRS-1 Serine Phosphorylation and Insulin Resistance in Skeletal Muscle From Pancreas Transplant Recipients

Predictors of Postpartum Diabetes in Women With Gestational Diabetes Mellitus

Complications

Orally Active Neurotrophin-Enhancing Agent Protects Against Dysfunctions of the Peripheral Nerves in Hyperglycemic Animals

The Ubiquitin-Proteasome System and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Rosiglitazone Treatment

Diabetes Alters Osmotic Swelling Characteristics and Membrane Conductance of Glial Cells in Rat Retina

Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy

Muscle Weakness: A Progressive Late Complication in Diabetic Distal Symmetric Polyneuropathy

Retinal Hemodynamics in Early Diabetic Macular Edema

Pharmacology & Therapeutics

Necdin and E2F4 Are Modulated by Rosiglitazone Therapy in Diabetic Human Adipose and Muscle Tissue

Novel Mechanism for Plasma Glucose–Lowering Action of Metformin in Streptozotocin-Induced Diabetic Rats

Genetics

Association of Protein Tyrosine Phosphatase-N1 Polymorphisms With Coronary Calcified Plaque in the Diabetes Heart Study

Variation in the Adiponutrin Gene Influences Its Expression and Associates With Obesity

Susceptibility to Type 1 Diabetes Is Associated With ApoCIII Gene Haplotypes

Metabolism

Role of Hepatic Glycogen Breakdown in Defective Counterregulation of Hypoglycemia in Intensively Treated Type 1 Diabetes

Effect of Nutrient Ingestion on Total-Body and Splanchnic Cortisol Production in Humans

The Greater Contribution of Gluconeogenesis to Glucose Production in Obesity Is Related to Increased Whole-Body Protein Catabolism

Signal Transduction

AMP-Activated Protein Kinase Activation by Adrenoceptors in L6 Skeletal Muscle Cells: Mediation by α1-Adrenoceptors Causing Glucose Uptake

Activation of Vascular Protein Kinase C-β Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance

Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance

Brief Genetics Reports

Association of Amino Acid Variants in the Activating Transcription Factor 6 Gene (ATF6) on 1q21-q23 With Type 2 Diabetes in Pima Indians

SLC12A3 (Solute Carrier Family 12 Member [Sodium/Chloride] 3) Polymorphisms Are Associated With End-Stage Renal Disease in Diabetic Nephropathy

Haplotype Structures and Large-Scale Association Testing of the 5′ AMP-Activated Protein Kinase Genes PRKAA2, PRKAB1, and PRKAB2 With Type 2 Diabetes

Genetic Analysis of ADIPOR1 and ADIPOR2 Candidate Polymorphisms for Type 2 Diabetes in the Caucasian Population

Errata

Erratum

Erratum

Erratum

This Issue

Current Issue

Mechanisms of [Ca²⁺]_i Transient Decrease in Cardiomyopathy of db/db Type 2 Diabetic Mice

AMP-Activated Protein Kinase Activation by Adrenoceptors in L6 Skeletal Muscle Cells: Mediation by α₁-Adrenoceptors Causing Glucose Uptake