SLC12A3 (Solute Carrier Family 12 Member [Sodium/Chloride] 3) Polymorphisms Are Associated With End-Stage Renal Disease in Diabetic Nephropathy

  1. Jae Hyeon Kim12,
  2. Hyoung Doo Shin3,
  3. Byung Lae Park3,
  4. Min Kyong Moon12,
  5. Young Min Cho34,
  6. Young Hwan Hwang4,
  7. Kook Whan Oh4,
  8. Seong Yeon Kim4,
  9. Hong Kyu Lee4,
  10. Curie Ahn4 and
  11. Kyong Soo Park34
  1. 1Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea
  2. 2Genome Research Center for Diabetes and Endocrine Disease, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
  3. 3Department of Genetic Epidemiology, SNP genetics, Seoul, Korea
  4. 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
  1. Address correspondence and reprint requests to Kyong Soo Park, MD, PhD, or Curie Ahn, MD, PhD, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul, 110-744, Korea. E-mail: kspark{at}snu.ac.kr or curie55{at}naver.com

Abstract

Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD). Genetic susceptibility plays an important role in the development and progression of diabetic nephropathy. Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. In this study, we examined whether the SLC12A3 gene locus is associated with ESRD resulting from diabetic nephropathy. We genotyped 11 common single nucleotide polymorphisms (SNPs) in the SLC12A3 gene in 177 patients with ESRD due to type 2 diabetes and 184 patients with diabetic retinopathy but with no signs of renal involvement. Three SNPs (g.34372G>A [Arg913Gln], g.39143G>A, and g.41727C>T) were found to be associated with ESRD due to diabetic nephropathy. These three SNPs were in complete linkage disequilibrium. Haplotype 4 in block 2 (18806C, 21822C, 34372A, 39143A, 39240T, 39375C, and 41727T) showed a significant association with ESRD due to type 2 diabetes (P = 0.0028). These results suggest that the SLC12A3 gene locus is associated with ESRD due to diabetic nephropathy.

Footnotes

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    C.A. and K.S.P. jointly supervised this project.

    • Accepted November 28, 2005.
    • Received August 8, 2005.
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  1. doi: 10.2337/diabetes.55.03.06.db05-1013 Diabetes March 2006 vol. 55 no. 3 843-848
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