Table of Contents

April 2006; 55 (4)

Signal Transduction

    • Bruno Guigas,
    • Luc Bertrand,
    • Nellie Taleux,
    • Marc Foretz,
    • Nicolas Wiernsperger,
    • Didier Vertommen,
    • Fabrizio Andreelli,
    • Benoit Viollet,
    • and Louis Hue

    5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase–Independent Effect on Glucokinase Translocation

    Diabetes April 2006 55:865-874; doi:10.2337/diabetes.55.04.06.db05-1178
    • Ana C.P. Thirone,
    • Lellean JeBailey,
    • Philip J. Bilan,
    • and Amira Klip

    Opposite Effect of JAK2 on Insulin-Dependent Activation of Mitogen-Activated Protein Kinases and Akt in Muscle Cells: Possible Target to Ameliorate Insulin Resistance

    Diabetes April 2006 55:942-951; doi:10.2337/diabetes.55.04.06.db05-1265
    • Luigi Laviola,
    • Sebastio Perrini,
    • Angelo Cignarelli,
    • Annalisa Natalicchio,
    • Anna Leonardini,
    • Francesca De Stefano,
    • Marilena Cuscito,
    • Michele De Fazio,
    • Vincenzo Memeo,
    • Vincenzo Neri,
    • Mauro Cignarelli,
    • Riccardo Giorgino,
    • and Francesco Giorgino

    Insulin Signaling in Human Visceral and Subcutaneous Adipose Tissue In Vivo

    Diabetes April 2006 55:952-961; doi:10.2337/diabetes.55.04.06.db05-1414

Islet Studies

    • Zhong Wang,
    • Tong Zhu,
    • Khaja K. Rehman,
    • Suzanne Bertera,
    • Jian Zhang,
    • Chunlian Chen,
    • Glenn Papworth,
    • Simon Watkins,
    • Massimo Trucco,
    • Paul D. Robbins,
    • Juan Li,
    • and Xiao Xiao

    Widespread and Stable Pancreatic Gene Transfer by Adeno-Associated Virus Vectors via Different Routes

    Diabetes April 2006 55:875-884; doi:10.2337/diabetes.55.04.06.db05-0927
    • Lyudmila I. Rachek,
    • Nancy P. Thornley,
    • Valentina I. Grishko,
    • Susan P. LeDoux,
    • and Glenn L. Wilson

    Protection of INS-1 Cells From Free Fatty Acid–Induced Apoptosis by Targeting hOGG1 to Mitochondria

    Diabetes April 2006 55:1022-1028; doi:10.2337/diabetes.55.04.06.db05-0865
    • Subhadra C. Gunawardana,
    • Jonathan V. Rocheleau,
    • W. Steven Head,
    • and David W. Piston

    Mechanisms of Time-Dependent Potentiation of Insulin Release: Involvement of Nitric Oxide Synthase

    Diabetes April 2006 55:1029-1033; doi:10.2337/diabetes.55.04.06.db05-1532
    • James Herrington,
    • Yun-Ping Zhou,
    • Randal M. Bugianesi,
    • Paula M. Dulski,
    • Yue Feng,
    • Vivien A. Warren,
    • McHardy M. Smith,
    • Martin G. Kohler,
    • Victor M. Garsky,
    • Manuel Sanchez,
    • Michael Wagner,
    • Kristin Raphaelli,
    • Priya Banerjee,
    • Chinweze Ahaghotu,
    • Denise Wunderler,
    • Birgit T. Priest,
    • John T. Mehl,
    • Maria L. Garcia,
    • Owen B. McManus,
    • Gregory J. Kaczorowski,
    • and Robert S. Slaughter

    Blockers of the Delayed-Rectifier Potassium Current in Pancreatic β-Cells Enhance Glucose-Dependent Insulin Secretion

    Diabetes April 2006 55:1034-1042; doi:10.2337/diabetes.55.04.06.db05-0788
    • Dongmin Liu,
    • Wei Zhen,
    • Zandong Yang,
    • Jeffery D. Carter,
    • Hongwei Si,
    • and Kathryn A. Reynolds

    Genistein Acutely Stimulates Insulin Secretion in Pancreatic β-Cells Through a cAMP-Dependent Protein Kinase Pathway

    Diabetes April 2006 55:1043-1050; doi:10.2337/diabetes.55.04.06.db05-1089
    • Juris J. Meier,
    • Lise L. Kjems,
    • Johannes D. Veldhuis,
    • Pierre Lefèbvre,
    • and Peter C. Butler

    Postprandial Suppression of Glucagon Secretion Depends on Intact Pulsatile Insulin Secretion: Further Evidence for the Intraislet Insulin Hypothesis

    Diabetes April 2006 55:1051-1056; doi:10.2337/diabetes.55.04.06.db05-1449
    • Takashi Tsuboi,
    • Magalie A. Ravier,
    • Laura E. Parton,
    • and Guy A. Rutter

    Sustained Exposure to High Glucose Concentrations Modifies Glucose Signaling and the Mechanics of Secretory Vesicle Fusion in Primary Rat Pancreatic β-Cells

    Diabetes April 2006 55:1057-1065; doi:10.2337/diabetes.55.04.06.db05-1577
    • Tara Beers Gibson,
    • Michael C. Lawrence,
    • Craig J. Gibson,
    • Colleen A. Vanderbilt,
    • Kathleen McGlynn,
    • Don Arnette,
    • Wei Chen,
    • Julie Collins,
    • Bashoo Naziruddin,
    • Marlon F. Levy,
    • Barbara E. Ehrlich,
    • and Melanie H. Cobb

    Inhibition of Glucose-Stimulated Activation of Extracellular Signal–Regulated Protein Kinases 1 and 2 by Epinephrine in Pancreatic β-Cells

    Diabetes April 2006 55:1066-1073; doi:10.2337/diabetes.55.04.06.db05-1266

Complications

    • Cheol Whee Park,
    • Hyeong Wook Kim,
    • Seung Hyun Ko,
    • Hyun Wha Chung,
    • Sun Woo Lim,
    • Chul Woo Yang,
    • Yoon Sik Chang,
    • Akira Sugawara,
    • YouFei Guan,
    • and Matthew D. Breyer

    Accelerated Diabetic Nephropathy in Mice Lacking the Peroxisome Proliferator–Activated Receptor α

    Diabetes April 2006 55:885-893; doi:10.2337/diabetes.55.04.06.db05-1329
    • Hernan Rincon-Choles,
    • Tetyana L. Vasylyeva,
    • Pablo E. Pergola,
    • Basant Bhandari,
    • Kusum Bhandari,
    • Jian-Hua Zhang,
    • Wen Wang,
    • Yves Gorin,
    • Jeffrey L. Barnes,
    • and Hanna E. Abboud

    ZΟ-1 Expression and Phosphorylation in Diabetic Nephropathy

    Diabetes April 2006 55:894-900; doi:10.2337/diabetes.55.04.06.db05-0355
    • Sanjay Srivastava,
    • Kota V. Ramana,
    • Ravinder Tammali,
    • Satish K. Srivastava,
    • and Aruni Bhatnagar

    Contribution of Aldose Reductase to Diabetic Hyperproliferation of Vascular Smooth Muscle Cells

    Diabetes April 2006 55:901-910; doi:10.2337/diabetes.55.04.06.db05-0932
    • Max Nieuwdorp,
    • Hans L. Mooij,
    • Jojanneke Kroon,
    • Bektas Atasever,
    • Jos A.E. Spaan,
    • Can Ince,
    • Frits Holleman,
    • Michaela Diamant,
    • Robert J. Heine,
    • Joost B.L. Hoekstra,
    • John J.P. Kastelein,
    • Erik S.G. Stroes,
    • and Hans Vink

    Endothelial Glycocalyx Damage Coincides With Microalbuminuria in Type 1 Diabetes

    Diabetes April 2006 55:1127-1132; doi:10.2337/diabetes.55.04.06.db05-1619
    • Andrea Natali,
    • Elena Toschi,
    • Stephanie Baldeweg,
    • Demetrio Ciociaro,
    • Stefania Favilla,
    • Luigi Saccà,
    • and Ele Ferrannini

    Clustering of Insulin Resistance With Vascular Dysfunction and Low-Grade Inflammation in Type 2 Diabetes

    Diabetes April 2006 55:1133-1140; doi:10.2337/diabetes.55.04.06.db05-1076
    • Ian S. Zagon,
    • Joseph W. Sassani,
    • and Patricia J. McLaughlin

    Insulin Treatment Ameliorates Impaired Corneal Reepithelialization in Diabetic Rats

    Diabetes April 2006 55:1141-1147; doi:10.2337/diabetes.55.04.06.db05-1581
    • Chad E.N. Reiter,
    • Xiaohua Wu,
    • Lakshman Sandirasegarane,
    • Makoto Nakamura,
    • Kirk A. Gilbert,
    • Ravi S.J. Singh,
    • Patrice E. Fort,
    • David A. Antonetti,
    • and Thomas W. Gardner

    Diabetes Reduces Basal Retinal Insulin Receptor Signaling: Reversal With Systemic and Local Insulin

    Diabetes April 2006 55:1148-1156; doi:10.2337/diabetes.55.04.06.db05-0744

Genetics

    • Nicholette D. Palmer,
    • Carl D. Langefeld,
    • Joel K. Campbell,
    • Adrienne H. Williams,
    • Mohammed Saad,
    • Jill M. Norris,
    • Stephen M. Haffner,
    • Jerome I. Rotter,
    • Lynne E. Wagenknecht,
    • Richard N. Bergman,
    • Stephen S. Rich,
    • and Donald W. Bowden

    Genetic Mapping of Disposition Index and Acute Insulin Response Loci on Chromosome 11q: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

    Diabetes April 2006 55:911-918; doi:10.2337/diabetes.55.04.06.db05-0813
    • Riphed Jaziri,
    • Stephane Lobbens,
    • Roberte Aubert,
    • Franck Péan,
    • Saida Lahmidi,
    • Martine Vaxillaire,
    • Isabelle Porchay,
    • Naïma Bellili,
    • Jean Tichet,
    • Beverley Balkau,
    • Philippe Froguel,
    • Michel Marre,
    • and Frédéric Fumeron

    The PPARG Pro12Ala Polymorphism Is Associated With a Decreased Risk of Developing Hyperglycemia Over 6 Years and Combines With the Effect of the APM1 G-11391A Single Nucleotide Polymorphism: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study

    Diabetes April 2006 55:1157-1162; doi:10.2337/diabetes.55.04.06.db05-0676
    • Ana-Claudia Rocha-Campos,
    • Rahma Melki,
    • Ren Zhu,
    • Nathalie Deruytter,
    • Diane Damotte,
    • Michel Dy,
    • André Herbelin,
    • and Henri-Jean Garchon

    Genetic and Functional Analysis of the Nkt1 Locus Using Congenic NOD Mice: Improved Vα14-NKT Cell Performance but Failure to Protect Against Type 1 Diabetes

    Diabetes April 2006 55:1163-1170; doi:10.2337/diabetes.55.04.06.db05-0908

Brief Genetics Reports

    • Momoko Horikoshi,
    • Kazuo Hara,
    • Jun Ohashi,
    • Kazuaki Miyake,
    • Katsushi Tokunaga,
    • Chikako Ito,
    • Masato Kasuga,
    • Ryozo Nagai,
    • and Takashi Kadowaki

    A Polymorphism in the AMPKα2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population

    Diabetes April 2006 55:919-923; doi:10.2337/diabetes.55.04.06.db05-0727
    • Claire Cheyssac,
    • Christian Dina,
    • Frédéric Leprêtre,
    • Valérie Vasseur-Delannoy,
    • Aurélie Dechaume,
    • Stéphane Lobbens,
    • Beverley Balkau,
    • Juan Ruiz,
    • Guillaume Charpentier,
    • François Pattou,
    • Erik Joly,
    • Marc Prentki,
    • Torben Hansen,
    • Oluf Pedersen,
    • Martine Vaxillaire,
    • and Philippe Froguel

    EIF4A2 Is a Positional Candidate Gene at the 3q27 Locus Linked to Type 2 Diabetes in French Families

    Diabetes April 2006 55:1171-1176; doi:10.2337/diabetes.55.04.06.db05-1298

Metabolism

    • Susanne Neschen,
    • Katsutaro Morino,
    • Jörg C. Rossbacher,
    • Rebecca L. Pongratz,
    • Gary W. Cline,
    • Saki Sono,
    • Matthew Gillum,
    • and Gerald I. Shulman

    Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

    Diabetes April 2006 55:924-928; doi:10.2337/diabetes.55.04.06.db05-0985
    • Graeme F. Mason,
    • Kitt F. Petersen,
    • Vincent Lebon,
    • Douglas L. Rothman,
    • and Gerald I. Shulman

    Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes

    Diabetes April 2006 55:929-934; doi:10.2337/diabetes.55.04.06.db05-1325
    • Eric D. Labonté,
    • R. Jason Kirby,
    • Nicholas M. Schildmeyer,
    • April M. Cannon,
    • Kevin W. Huggins,
    • and David Y. Hui

    Group 1B Phospholipase A2–Mediated Lysophospholipid Absorption Directly Contributes to Postprandial Hyperglycemia

    Diabetes April 2006 55:935-941; doi:10.2337/diabetes.55.04.06.db05-1286

Obesity Studies

    • Sanjin Zvonic,
    • Andrey A. Ptitsyn,
    • Steven A. Conrad,
    • L. Keith Scott,
    • Z. Elizabeth Floyd,
    • Gail Kilroy,
    • Xiying Wu,
    • Brian C. Goh,
    • Randall L. Mynatt,
    • and Jeffrey M. Gimble

    Characterization of Peripheral Circadian Clocks in Adipose Tissues

    Diabetes April 2006 55:962-970; doi:10.2337/diabetes.55.04.06.db05-0873
    • Dai Chida,
    • Toshimasa Osaka,
    • Okito Hashimoto,
    • and Yoichiro Iwakura

    Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice

    Diabetes April 2006 55:971-977; doi:10.2337/diabetes.55.04.06.db05-1250
    • Deborah J. Clegg,
    • Lynda M. Brown,
    • Stephen C. Woods,
    • and Stephen C. Benoit

    Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin

    Diabetes April 2006 55:978-987; doi:10.2337/diabetes.55.04.06.db05-1339
    • Isabelle Bady,
    • Nell Marty,
    • Michel Dallaporta,
    • Martine Emery,
    • Jöel Gyger,
    • David Tarussio,
    • Marc Foretz,
    • and Bernard Thorens

    Evidence From Glut2-Null Mice That Glucose Is a Critical Physiological Regulator of Feeding

    Diabetes April 2006 55:988-995; doi:10.2337/diabetes.55.04.06.db05-1386

Immunology and Transplantation

    • Susanne Skarsvik,
    • Julia Puranen,
    • Jarno Honkanen,
    • Merja Roivainen,
    • Jorma Ilonen,
    • Hanna Holmberg,
    • Johnny Ludvigsson,
    • and Outi Vaarala

    Decreased In Vitro Type 1 Immune Response Against Coxsackie Virus B4 in Children With Type 1 Diabetes

    Diabetes April 2006 55:996-1003; doi:10.2337/diabetes.55.04.06.db05-0630
    • Biliana Lozanoska-Ochser,
    • Francesca Barone,
    • Costantino Pitzalis,
    • and Mark Peakman

    Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic β-Cell–Specific CD8 T-Cells

    Diabetes April 2006 55:1004-1010; doi:10.2337/diabetes.55.04.06.db05-1261
    • Dongmei Chen,
    • Nan Zhang,
    • Shuang Fu,
    • Bernd Schröppel,
    • Qiongfen Guo,
    • Alexandre Garin,
    • Sergio A. Lira,
    • and Jonathan S. Bromberg

    CD4+CD25+ Regulatory T-Cells Inhibit the Islet Innate Immune Response and Promote Islet Engraftment

    Diabetes April 2006 55:1011-1021; doi:10.2337/diabetes.55.04.06.db05-1048

Pathophysiology

    • Anny H. Xiang,
    • Chengwei Wang,
    • Ruth K. Peters,
    • Enrique Trigo,
    • Siri L. Kjos,
    • and Thomas A. Buchanan

    Coordinate Changes in Plasma Glucose and Pancreatic β-Cell Function in Latino Women at High Risk for Type 2 Diabetes

    Diabetes April 2006 55:1074-1079; doi:10.2337/diabetes.55.04.06.db05-1109
    • Owen Chan,
    • Wanling Zhu,
    • Yuyan Ding,
    • Rory J. McCrimmon,
    • and Robert S. Sherwin

    Blockade of GABAA Receptors in the Ventromedial Hypothalamus Further Stimulates Glucagon and Sympathoadrenal but Not the Hypothalamo-Pituitary-Adrenal Response to Hypoglycemia

    Diabetes April 2006 55:1080-1087; doi:10.2337/diabetes.55.04.06.db05-0958
    • Ewan C. McNay,
    • Anne Williamson,
    • Rory J. McCrimmon,
    • and Robert S. Sherwin

    Cognitive and Neural Hippocampal Effects of Long-Term Moderate Recurrent Hypoglycemia

    Diabetes April 2006 55:1088-1095; doi:10.2337/diabetes.55.04.06.db05-1314
    • Björn Ellger,
    • Yves Debaveye,
    • Ilse Vanhorebeek,
    • Lies Langouche,
    • Annapaula Giulietti,
    • Evelyne Van Etten,
    • Paul Herijgers,
    • Chantal Mathieu,
    • and Greet Van den Berghe

    Survival Benefits of Intensive Insulin Therapy in Critical Illness: Impact of Maintaining Normoglycemia Versus Glycemia-Independent Actions of Insulin

    Diabetes April 2006 55:1096-1105; doi:10.2337/diabetes.55.04.06.db05-1434
    • Sanne M. Manschot,
    • Augustina M.A. Brands,
    • Jeroen van der Grond,
    • Roy P.C. Kessels,
    • Ale Algra,
    • L. Jaap Kappelle,
    • and Geert Jan Biessels

    Brain Magnetic Resonance Imaging Correlates of Impaired Cognition in Patients With Type 2 Diabetes

    Diabetes April 2006 55:1106-1113; doi:10.2337/diabetes.55.04.06.db05-1323
    • Andreas Festa,
    • Ken Williams,
    • Ralph D’Agostino, Jr.,
    • Lynne E. Wagenknecht,
    • and Steven M. Haffner

    The Natural Course of β-Cell Function in Nondiabetic and Diabetic Individuals: The Insulin Resistance Atherosclerosis Study

    Diabetes April 2006 55:1114-1120; doi:10.2337/diabetes.55.04.06.db05-1100
    • Philip A. Goldberg,
    • Ram Weiss,
    • Rory J. McCrimmon,
    • Ellen V. Hintz,
    • James D. Dziura,
    • and Robert S. Sherwin

    Antecedent Hypercortisolemia Is Not Primarily Responsible for Generating Hypoglycemia-Associated Autonomic Failure

    Diabetes April 2006 55:1121-1126; doi:10.2337/diabetes.55.04.06.db05-1169
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This Issue

April 2006; 55 (4)
  1. Signal Transduction
  2. Islet Studies
  3. Complications
  4. Genetics
  5. Brief Genetics Reports
  6. Metabolism
  7. Obesity Studies
  8. Immunology and Transplantation
  9. Pathophysiology

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