Table of Contents

• Ming V. Li,
• Benny Chang,
• Minako Imamura,
• Naravat Poungvarin,
• and Lawrence Chan

Glucose-Dependent Transcriptional Regulation by an Evolutionarily Conserved Glucose-Sensing Module

• Jean Buteau,
• Marianne L. Spatz,
• and Domenico Accili

Transcription Factor FoxO1 Mediates Glucagon-Like Peptide-1 Effects on Pancreatic β-Cell Mass

• Koujiro Imoto,
• Daisuke Kukidome,
• Takeshi Nishikawa,
• Takako Matsuhisa,
• Kazuhiro Sonoda,
• Kazuo Fujisawa,
• Miyuki Yano,
• Hiroyuki Motoshima,
• Tetsuya Taguchi,
• Kaku Tsuruzoe,
• Takeshi Matsumura,
• Hidenori Ichijo,
• and Eiichi Araki

Impact of Mitochondrial Reactive Oxygen Species and Apoptosis Signal–Regulating Kinase 1 on Insulin Signaling

• Håkan K.R. Karlsson,
• Maria Ahlsén,
• Juleen R. Zierath,
• Harriet Wallberg-Henriksson,
• and Heikki A. Koistinen

Insulin Signaling and Glucose Transport in Skeletal Muscle From First-Degree Relatives of Type 2 Diabetic Patients

• Audrey Riboulet-Chavey,
• Anne Pierron,
• Isabelle Durand,
• Joseph Murdaca,
• Jean Giudicelli,
• and Emmanuel Van Obberghen

Methylglyoxal Impairs the Insulin Signaling Pathways Independently of the Formation of Intracellular Reactive Oxygen Species

• Hans P.M.M. Lauritzen,
• Thorkil Ploug,
• Clara Prats,
• Jeremy M. Tavaré,
• and Henrik Galbo

Imaging of Insulin Signaling in Skeletal Muscle of Living Mice Shows Major Role of T-Tubules

• Tetsuji Shinohara,
• Naohiko Takahashi,
• Tatsuhiko Ooie,
• Masahide Hara,
• Sakuji Shigematsu,
• Mikiko Nakagawa,
• Hidetoshi Yonemochi,
• Tetsunori Saikawa,
• and Hironobu Yoshimatsu

Phosphatidylinositol 3-Kinase–Dependent Activation of Akt, an Essential Signal for Hyperthermia-Induced Heat-Shock Protein 72, Is Attenuated in Streptozotocin-Induced Diabetic Heart

• Lisa M. Federico,
• Mark Naples,
• Denise Taylor,
• and Khosrow Adeli

Intestinal Insulin Resistance and Aberrant Production of Apolipoprotein B48 Lipoproteins in an Animal Model of Insulin Resistance and Metabolic Dyslipidemia: Evidence for Activation of Protein Tyrosine Phosphatase-1B, Extracellular Signal–Related Kinase, and Sterol Regulatory Element–Binding Protein-1c in the Fructose-Fed Hamster Intestine

• Maria C. García,
• Ingrid Wernstedt,
• Anna Berndtsson,
• Maria Enge,
• Michal Bell,
• Olof Hultgren,
• Michael Horn,
• Bo Ahrén,
• Sven Enerback,
• Claes Ohlsson,
• Ville Wallenius,
• and John-Olov Jansson

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice

• Miguel López,
• Christopher J. Lelliott,
• Sulay Tovar,
• Wendy Kimber,
• Rosalía Gallego,
• Sam Virtue,
• Margaret Blount,
• Maria J. Vázquez,
• Nick Finer,
• Trevor J. Powles,
• Stephen O’Rahilly,
• Asish K. Saha,
• Carlos Diéguez,
• and Antonio J. Vidal-Puig

Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA

• Ken K. Ong,
• Jan Frystyk,
• Allan Flyvbjerg,
• Clive J. Petry,
• Andy Ness,
• and David B. Dunger

Sex-Discordant Associations With Adiponectin Levels and Lipid Profiles in Children

• Hyun Bae Kim,
• Minyoung Kong,
• Tae Min Kim,
• Young Ho Suh,
• Won-Ho Kim,
• Joo Hyun Lim,
• Ji Hyun Song,
• and Myeong Ho Jung

NFATc4 and ATF3 Negatively Regulate Adiponectin Gene Expression in 3T3-L1 Adipocytes

• André Tchernof,
• Chantal Bélanger,
• Anne-Sophie Morisset,
• Christian Richard,
• Jacques Mailloux,
• Philippe Laberge,
• and Pierre Dupont

Regional Differences in Adipose Tissue Metabolism in Women: Minor Effect of Obesity and Body Fat Distribution

• Vincenzo Cirulli,
• Jessie Zalatan,
• Michael McMaster,
• Robyn Prinsen,
• Daniel R. Salomon,
• Camillo Ricordi,
• Bruce E. Torbett,
• Paolo Meda,
• and Laura Crisa

The Class I HLA Repertoire of Pancreatic Islets Comprises the Nonclassical Class Ib Antigen HLA-G

• Sung-Hee Ihm,
• Ippei Matsumoto,
• Toshiya Sawada,
• Masahiko Nakano,
• Hui J. Zhang,
• Jeffrey D. Ansite,
• David E.R. Sutherland,
• and Bernhard J. Hering

Effect of Donor Age on Function of Isolated Human Islets

• María D. López-Avalos,
• Valérie F. Duvivier-Kali,
• Gang Xu,
• Susan Bonner-Weir,
• Arun Sharma,
• and Gordon C. Weir

Evidence for a Role of the Ubiquitin-Proteasome Pathway in Pancreatic Islets

• Jacqueline A. Koehler and
• Daniel J. Drucker

Activation of Glucagon-Like Peptide-1 Receptor Signaling Does Not Modify the Growth or Apoptosis of Human Pancreatic Cancer Cells

• Felicia Ranta,
• Diana Avram,
• Susanne Berchtold,
• Martina Düfer,
• Gisela Drews,
• Florian Lang,
• and Susanne Ullrich

Dexamethasone Induces Cell Death in Insulin-Secreting Cells, an Effect Reversed by Exendin-4

• Yukiko Kaneko,
• Yuka Kimura,
• Hideo Kimura,
• and Ichiro Niki

l-Cysteine Inhibits Insulin Release From the Pancreatic β-Cell : Possible Involvement of Metabolic Production of Hydrogen Sulfide, a Novel Gasotransmitter

• J. Jason Collier,
• Patrick T. Fueger,
• Hans E. Hohmeier,
• and Christopher B. Newgard

Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines

• Tobias Rydgren,
• Daniel Bengtsson,
• and Stellan Sandler

Complete Protection Against Interleukin-1β–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap

• Geraldine Parnaud,
• Eva Hammar,
• Dominique G. Rouiller,
• Mathieu Armanet,
• Philippe A. Halban,
• and Domenico Bosco

Blockade of β1 Integrin–Laminin-5 Interaction Affects Spreading and Insulin Secretion of Rat β-Cells Attached on Extracellular Matrix

• Edwin P. Kwan,
• Li Xie,
• Laura Sheu,
• Christopher J. Nolan,
• Marc Prentki,
• Andrea Betz,
• Nils Brose,
• and Herbert Y. Gaisano

Munc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance

• Kunihiro Ichinose,
• Yohei Maeshima,
• Yoshihiko Yamamoto,
• Masaru Kinomura,
• Kumiko Hirokoshi,
• Hiroyuki Kitayama,
• Yuki Takazawa,
• Hitoshi Sugiyama,
• Yasushi Yamasaki,
• Naoki Agata,
• and Hirofumi Makino

2-(8-Hydroxy-6-Methoxy-1-Oxo-1H-2-Benzopyran-3-yl) Propionic Acid, an Inhibitor of Angiogenesis, Ameliorates Renal Alterations in Obese Type 2 Diabetic Mice

• Emilio Ruiz,
• Antonio Gordillo-Moscoso,
• Eugenia Padilla,
• Santiago Redondo,
• Enrique Rodriguez,
• Fernando Reguillo,
• Ana M. Briones,
• Cornelis van Breemen,
• Elena Okon,
• and Teresa Tejerina

Human Vascular Smooth Muscle Cells From Diabetic Patients Are Resistant to Induced Apoptosis Due to High Bcl-2 Expression

• Jonathan M. Starkey,
• Sigmund J. Haidacher,
• Wanda S. LeJeune,
• Xiaoquan Zhang,
• Brian C. Tieu,
• Sanjeev Choudhary,
• Allan R. Brasier,
• Larry A. Denner,
• and Ronald G. Tilton

Diabetes-Induced Activation of Canonical and Noncanonical Nuclear Factor-κB Pathways in Renal Cortex

• Bingmei Yang,
• Andrea D. Hodgkinson,
• Peter J. Oates,
• Hyug Moo Kwon,
• Beverley A. Millward,
• and Andrew G. Demaine

Elevated Activity of Transcription Factor Nuclear Factor of Activated T-Cells 5 (NFAT5) and Diabetic Nephropathy

• Aneliya I. Parvanova,
• Roberto Trevisan,
• Ilian P. Iliev,
• Borislav D. Dimitrov,
• Monica Vedovato,
• Antonio Tiengo,
• Giuseppe Remuzzi,
• and Piero Ruggenenti

Insulin Resistance and Microalbuminuria: A Cross-Sectional, Case-Control Study of 158 Patients With Type 2 Diabetes and Different Degrees of Urinary Albumin Excretion

• Georgia Pambianco,
• Tina Costacou,
• Demetrius Ellis,
• Dorothy J. Becker,
• Ronald Klein,
• and Trevor J. Orchard

The 30-Year Natural History of Type 1 Diabetes Complications: The Pittsburgh Epidemiology of Diabetes Complications Study Experience

• Mika Nakae,
• Hideki Kamiya,
• Keiko Naruse,
• Naoichi Horio,
• Yasuki Ito,
• Ryuichi Mizubayashi,
• Yoji Hamada,
• Eitaro Nakashima,
• Noboru Akiyama,
• Yasuko Kobayashi,
• Atsuko Watarai,
• Nachi Kimura,
• Masayuki Horiguchi,
• Yasuhiko Tabata,
• Yutaka Oiso,
• and Jiro Nakamura

Effects of Basic Fibroblast Growth Factor on Experimental Diabetic Neuropathy in Rats

• Claire Demiot,
• Maylis Tartas,
• Bérengère Fromy,
• Pierre Abraham,
• Jean Louis Saumet,
• and Dominique Sigaudo-Roussel

Aldose Reductase Pathway Inhibition Improved Vascular and C-Fiber Functions, Allowing for Pressure-Induced Vasodilation Restoration During Severe Diabetic Neuropathy

• Kazuo Hara,
• Momoko Horikoshi,
• Hiroji Kitazato,
• Chikako Ito,
• Mitsuhiko Noda,
• Jun Ohashi,
• Philippe Froguel,
• Katsushi Tokunaga,
• Kazuyuki Tobe,
• Ryozo Nagai,
• and Takashi Kadowaki

Hepatocyte Nuclear Factor-4α P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population

• Theresa A. Aly,
• Elise Eller,
• Akane Ide,
• Katherine Gowan,
• Sunanda R. Babu,
• Henry A. Erlich,
• Marian J. Rewers,
• George S. Eisenbarth,
• and Pamela R. Fain

Multi-SNP Analysis of MHC Region: Remarkable Conservation of HLA-A1-B8-DR3 Haplotype

• Veit Schoenborn,
• Iris M. Heid,
• Caren Vollmert,
• Arno Lingenhel,
• Ted D. Adams,
• Paul N. Hopkins,
• Thomas Illig,
• Robert Zimmermann,
• Rudolf Zechner,
• Steven C. Hunt,
• and Florian Kronenberg

The ATGL Gene Is Associated With Free Fatty Acids, Triglycerides, and Type 2 Diabetes

• Deborah J. Smyth,
• Jason D. Cooper,
• Christopher E. Lowe,
• Sarah Nutland,
• Neil M. Walker,
• David G. Clayton,
• and John A. Todd

No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases

• Daniela Scarpelli,
• Marina Cardellini,
• Francesco Andreozzi,
• Emanuela Laratta,
• Marta Letizia Hribal,
• Maria Adelaide Marini,
• Vittorio Tassi,
• Renato Lauro,
• Francesco Perticone,
• and Giorgio Sesti

Variants of the Interleukin-10 Promoter Gene Are Associated With Obesity and Insulin Resistance but Not Type 2 Diabetes in Caucasian Italian Subjects

• Aleksey V. Matveyenko and
• Casey M. Donovan

Metabolic Sensors Mediate Hypoglycemic Detection at the Portal Vein

• Muhammad A. Abdul-Ghani,
• Christopher P. Jenkinson,
• Dawn K. Richardson,
• Devjit Tripathy,
• and Ralph A. DeFronzo

Insulin Secretion and Action in Subjects With Impaired Fasting Glucose and Impaired Glucose Tolerance: Results From the Veterans Administration Genetic Epidemiology Study

• Lucy H. Clerk,
• Michelle A. Vincent,
• Linda A. Jahn,
• Zhenqi Liu,
• Jonathan R. Lindner,
• and Eugene J. Barrett

Obesity Blunts Insulin-Mediated Microvascular Recruitment in Human Forearm Muscle

• Anna Sapone,
• Laura de Magistris,
• Michelle Pietzak,
• Maria G. Clemente,
• Amit Tripathi,
• Francesco Cucca,
• Rosanna Lampis,
• Deborah Kryszak,
• Maria Cartenì,
• Maddalena Generoso,
• Dario Iafusco,
• Francesco Prisco,
• Francesca Laghi,
• Gabriele Riegler,
• Romano Carratu,
• Debra Counts,
• and Alessio Fasano

Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives

• Patrice D. Cani,
• Claude Knauf,
• Miguel A. Iglesias,
• Daniel J. Drucker,
• Nathalie M. Delzenne,
• and Rémy Burcelin

Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor

• Geesje M. Dallinga-Thie,
• Arie van Tol,
• Hiroaki Hattori,
• Patrick C.N. Rensen,
• and Eric J.G. Sijbrands

Plasma Phospholipid Transfer Protein Activity Is Decreased in Type 2 Diabetes During Treatment With Atorvastatin: A Role for Apolipoprotein E?

• Peter Kovacs,
• Michael Stumvoll,
• Clifton Bogardus,
• Robert L. Hanson,
• and Leslie J. Baier

A Functional Tyr1306Cys Variant in LARG Is Associated With Increased Insulin Action in Vivo

• David R. Gable,
• Jefferey W. Stephens,
• Jackie A. Cooper,
• George J. Miller,
• and Steve E. Humphries

Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men

• Lu Qi,
• Alessandro Doria,
• JoAnn E. Manson,
• James B. Meigs,
• David Hunter,
• Christos S. Mantzoros,
• and Frank B. Hu

Adiponectin Genetic Variability, Plasma Adiponectin, and Cardiovascular Risk in Patients With Type 2 Diabetes

• Valma Harjutsalo,
• Antti Reunanen,
• and Jaakko Tuomilehto

Differential Transmission of Type 1 Diabetes from Diabetic Fathers and Mothers to Their Offspring

Erratum