The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults

TABLE 2

Genotype frequencies of the insulin gene polymorphisms in the sample groups

Marker Genotype UKPDS LADA (n = 232)* W2 Repository LADA (n = 131)* Exeter YT2D LADA (n = 37)* All cases (n = 400)* Control subjects (n = 332)*
−23HphI
AA 165 (0.71) 81 (0.62) 30 (0.81) 276 (0.69) 159 (0.49)
AT 58 (0.25) 40 (0.31) 4 (0.11) 102 (0.26) 141 (0.43)
TT 8 (0.04) 10 (0.08) 3 (0.08) 21 (0.05) 27 (0.08)
+1404Fnu4HI
CC 182 (0.80) 89 (0.69) 30 (0.81) 301 (0.76) 199 (0.61)
CA 42 (0.18) 31 (0.24) 5 (0.14) 78 (0.20) 105 (0.32)
AA 5 (0.02) 10 (0.08) 2 (0.05) 17 (0.04) 20 (0.06)
+3580MspI
CC 81 (0.35) 50 (0.39) 20 (0.54) 151 (0.38) 147 (0.45)
CT 97 (0.42) 60 (0.46) 12 (0.32) 169 (0.42) 143 (0.43)
TT 53 (0.23) 20 (0.15) 5 (0.14) 78 (0.20) 39 (0.12)
  • Data are n (frequency).

  • *

    * Individuals in whom genotyping was attempted.

This Article

  1. Diabetes vol. 55 no. 6 1890-1894