The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults

TABLE 3

Single-point association analysis of the −23HphI, +1404Fnu4HI, and +3580MspI SNPs with disease in the LADA groups assuming dominance for the protective allele

Sample group (n)* −23HphI
+1404Fnu4HI
+3580MspI
OR (95% CI) P OR (95% CI) P OR (95% CI) P
UKPDS LADA (232) 0.38 (0.26–0.55) 9.3 × 10−8 0.41 (0.27–0.62) 6.8 × 10−6 0.45 (0.28–0.73) 7.2 × 10−4
W2 Repository LADA (131) 0.58 (0.38–0.90) 0.013 0.73 (0.46–1.15) 0.16 0.74 (0.40–1.40) 0.35
Exeter YT2D LADA (37) 0.22 (0.08–0.53) 0.00019 0.37 (0.13–0.90) 0.019 0.86 (0.31–3.00) 0.79
All cases (400) 0.42 (0.31–0.58) 2.4 × 10−8 0.50 (0.36–0.70) 3.2 × 10−5 0.55 (0.35–0.85) 0.0046
  • ORs (95% CIs) were calculated based on the dominant model of inheritance for the allele at each SNP known to be associated with protection from type 1 diabetes: 23HphI, dominant for T allele (VNTR class III alleles); +1404Fnu4HI, dominant for A allele; +3580MspI, dominant for C allele. All comparisons were carried out between the case group concerned and the common control set.

  • *

    * Individuals in whom genotyping was attempted.

This Article

  1. Diabetes vol. 55 no. 6 1890-1894