The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults

TABLE 4

Estimated haplotype frequencies in the sample groups

Haplotype (type 1 diabetes defined) Haplotype* UKPDS LADA W2 Repository LADA Exeter YT2D LADA All cases Control subjects
n 232 131 37 400 332
Class ID− ACT 0.440 0.386 0.297 0.409 0.336
Class IC+/ID+ ACC and AAC 0.401 0.385 0.568 0.411 0.364
Class III PH TAC 0.115 0.190 0.122 0.140 0.222
Class III VPH TCC 0.045 0.039 0.014 0.040 0.078
P 1.7 × 10−6 0.056 1.0 × 10−3 7.9 × 10−6
  • *

    * Allelic combination at −23HphI, +1404Fnu4HI, and +3580MspI SNPs. P = haplotype trend regression P value to test for difference in haplotype frequency distributions between case and control subjects.

This Article

  1. Diabetes vol. 55 no. 6 1890-1894