Table of Contents

Perspectives in Diabetes

Select this article
- Juliet A. Emamaullee and
- A.M. James Shapiro
Interventional Strategies to Prevent β-Cell Apoptosis in Islet Transplantation
Diabetes July 2006 55:1907-1914; doi:10.2337/db05-1254

Signal Transduction

Select this article
- Haiming Cao,
- Kazuhisa Maeda,
- Cem Z. Gorgun,
- Hyo-Jeong Kim,
- So-Young Park,
- Gerald I. Shulman,
- Jason K. Kim,
- and Gökhan S. Hotamisligil
Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice
Diabetes July 2006 55:1915-1922; doi:10.2337/db05-1496
Select this article
- Dorothy Zelent,
- Maria L. Golson,
- Brigitte Koeberlein,
- Roel Quintens,
- Leentje van Lommel,
- Carol Buettger,
- Heather Weik-Collins,
- Rebecca Taub,
- Joseph Grimsby,
- Frans Schuit,
- Klaus H. Kaestner,
- and Franz M. Matschinsky
A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells
Diabetes July 2006 55:1923-1929; doi:10.2337/db06-0151
Select this article
- Sudha B. Biddinger,
- Makoto Miyazaki,
- Jeremie Boucher,
- James M. Ntambi,
- and C. Ronald Kahn
Leptin Suppresses Stearoyl-CoA Desaturase 1 by Mechanisms Independent of Insulin and Sterol Regulatory Element–Binding Protein-1c
Diabetes July 2006 55:2032-2041; doi:10.2337/db05-0742
Select this article
- Varman T. Samuel,
- Cheol Soo Choi,
- Trevor G. Phillips,
- Anthony J. Romanelli,
- John G. Geisler,
- Sanjay Bhanot,
- Robert McKay,
- Brett Monia,
- John R. Shutter,
- Richard A. Lindberg,
- Gerald I. Shulman,
- and Murielle M. Veniant
Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action
Diabetes July 2006 55:2042-2050; doi:10.2337/db05-0705
Select this article
- Jonas T. Treebak,
- Stephan Glund,
- Atul Deshmukh,
- Ditte K. Klein,
- Yun Chau Long,
- Thomas E. Jensen,
- Sebastian B. Jørgensen,
- Benoit Viollet,
- Leif Andersson,
- Dietbert Neumann,
- Theo Wallimann,
- Erik A. Richter,
- Alexander V. Chibalin,
- Juleen R. Zierath,
- and Jørgen F.P. Wojtaszewski
AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits
Diabetes July 2006 55:2051-2058; doi:10.2337/db06-0175
Select this article
- Krishna M. Boini,
- Anita M. Hennige,
- Dan Yang Huang,
- Björn Friedrich,
- Monica Palmada,
- Christoph Boehmer,
- Florian Grahammer,
- Ferruh Artunc,
- Susanne Ullrich,
- Diana Avram,
- Hartmut Osswald,
- Peer Wulff,
- Dietmar Kuhl,
- Volker Vallon,
- Hans-Ulrich Häring,
- and Florian Lang
Serum- and Glucocorticoid-Inducible Kinase 1 Mediates Salt Sensitivity of Glucose Tolerance
Diabetes July 2006 55:2059-2066; doi:10.2337/db05-1038
Select this article
- Henning F. Kramer,
- Carol A. Witczak,
- Nobuharu Fujii,
- Niels Jessen,
- Eric B. Taylor,
- David E. Arnolds,
- Kei Sakamoto,
- Michael F. Hirshman,
- and Laurie J. Goodyear
Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle
Diabetes July 2006 55:2067-2076; doi:10.2337/db06-0150
Select this article
- Johanna T. Lanner,
- Abram Katz,
- Pasi Tavi,
- Marie E. Sandström,
- Shi-Jin Zhang,
- Charlott Wretman,
- Stephen James,
- Jérémy Fauconnier,
- Jan Lännergren,
- Joseph D. Bruton,
- and Håkan Westerblad
The Role of Ca²⁺ Influx for Insulin-Mediated Glucose Uptake in Skeletal Muscle
Diabetes July 2006 55:2077-2083; doi:10.2337/db05-1613
Select this article
- Corinne Leloup,
- Christophe Magnan,
- Alexandre Benani,
- Emilie Bonnet,
- Thierry Alquier,
- Géraldine Offer,
- Audrey Carriere,
- Alain Périquet,
- Yvette Fernandez,
- Alain Ktorza,
- Louis Casteilla,
- and Luc Pénicaud
Mitochondrial Reactive Oxygen Species Are Required for Hypothalamic Glucose Sensing
Diabetes July 2006 55:2084-2090; doi:10.2337/db06-0086

Islet Studies

Select this article
- Kazunobu Oyama,
- Kohtaro Minami,
- Katsuhiko Ishizaki,
- Masanori Fuse,
- Takashi Miki,
- and Susumu Seino
Spontaneous Recovery From Hyperglycemia by Regeneration of Pancreatic β-Cells in Kir6.2G132S Transgenic Mice
Diabetes July 2006 55:1930-1938; doi:10.2337/db05-1459
Select this article
- Aleksey V. Matveyenko and
- Peter C. Butler
β-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2 Diabetes
Diabetes July 2006 55:2106-2114; doi:10.2337/db05-1672

Pathophysiology

Select this article
- Michael S. Stalvey,
- Christian Muller,
- Desmond A. Schatz,
- Clive H. Wasserfall,
- Martha L. Campbell-Thompson,
- Douglas W. Theriaque,
- Terence R. Flotte,
- and Mark A. Atkinson
Cystic Fibrosis Transmembrane Conductance Regulator Deficiency Exacerbates Islet Cell Dysfunction After β-Cell Injury
Diabetes July 2006 55:1939-1945; doi:10.2337/db05-1647

Complications

Select this article
- Eric C.M. Ho,
- Karen S.L. Lam,
- Yuk Shan Chen,
- Johnny C.W. Yip,
- Meena Arvindakshan,
- Shin-Ichiro Yamagishi,
- Soroku Yagihashi,
- Peter J. Oates,
- Craig A. Ellery,
- Stephen S.M. Chung,
- and Sookja K. Chung
Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH₂-Terminal Kinase Activation, Depletion of Reduced Glutathione, Increased Superoxide Accumulation, and DNA Damage
Diabetes July 2006 55:1946-1953; doi:10.2337/db05-1497
Select this article
- Yoshimasa Aso,
- Ruriko Yamamoto,
- Sadao Wakabayashi,
- Toshihiko Uchida,
- Kan Takayanagi,
- Kohzo Takebayashi,
- Takehiko Okuno,
- Teruo Inoue,
- Koichi Node,
- Takashi Tobe,
- Toshihiko Inukai,
- and Yasuko Nakano
Comparison of Serum High–Molecular Weight (HMW) Adiponectin With Total Adiponectin Concentrations in Type 2 Diabetic Patients With Coronary Artery Disease Using a Novel Enzyme-Linked Immunosorbent Assay to Detect HMW Adiponectin
Diabetes July 2006 55:1954-1960; doi:10.2337/db05-1525
Select this article
- Darin Dobler,
- Naila Ahmed,
- Lijiang Song,
- Kevin E. Eboigbodin,
- and Paul J. Thornalley
Increased Dicarbonyl Metabolism in Endothelial Cells in Hyperglycemia Induces Anoikis and Impairs Angiogenesis by RGD and GFOGER Motif Modification
Diabetes July 2006 55:1961-1969; doi:10.2337/db05-1634
Select this article
- Lenin Mahimainathan,
- Falguni Das,
- Balachandar Venkatesan,
- and Goutam Ghosh Choudhury
Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN
Diabetes July 2006 55:2115-2125; doi:10.2337/db05-1326
Select this article
- Guang-da Xiang,
- Lin Xu,
- Lin-shuang Zhao,
- Ling Yue,
- and Jie Hou
The Relationship Between Plasma Osteoprotegerin and Endothelium-Dependent Arterial Dilation in Type 2 Diabetes
Diabetes July 2006 55:2126-2131; doi:10.2337/db06-0231
Select this article
- Jan Wysocki,
- Minghao Ye,
- Maria José Soler,
- Susan B. Gurley,
- Hong D. Xiao,
- Kenneth E. Bernstein,
- Thomas M. Coffman,
- Sheldon Chen,
- and Daniel Batlle
ACE and ACE2 Activity in Diabetic Mice
Diabetes July 2006 55:2132-2139; doi:10.2337/db06-0033

Genetics

Select this article
- Daphna Weissglas-Volkov,
- Adriana Huertas-Vazquez,
- Elina Suviolahti,
- Jenny Lee,
- Christopher Plaisier,
- Samuel Canizales-Quinteros,
- Teresa Tusie-Luna,
- Carlos Aguilar-Salinas,
- Marja-Riitta Taskinen,
- and Päivi Pajukanta
Common Hepatic Nuclear Factor-4α Variants Are Associated With High Serum Lipid Levels and the Metabolic Syndrome
Diabetes July 2006 55:1970-1977; doi:10.2337/db06-0035
Select this article
- Jean M. Jasinski,
- Liping Yu,
- Maki Nakayama,
- Marcella M. Li,
- Myra A. Lipes,
- George S. Eisenbarth,
- and Edwin Liu
Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2^g7 Homozygosity, and Insulin 2 Gene Knockout
Diabetes July 2006 55:1978-1984; doi:10.2337/db06-0058
Select this article
- Donald W. Bowden,
- Megan Rudock,
- Julie Ziegler,
- Allison B. Lehtinen,
- Jianzhao Xu,
- Lynne E. Wagenknecht,
- David Herrington,
- Stephen S. Rich,
- Barry I. Freedman,
- J. Jeffrey Carr,
- and Carl D. Langefeld
Coincident Linkage of Type 2 Diabetes, Metabolic Syndrome, and Measures of Cardiovascular Disease in a Genome Scan of the Diabetes Heart Study
Diabetes July 2006 55:1985-1994; doi:10.2337/db06-0003
Select this article
- Cuilin Zhang,
- Ruy Lopez-Ridaura,
- David J. Hunter,
- Nader Rifai,
- and Frank B. Hu
Common Variants of the Endothelial Nitric Oxide Synthase Gene and the Risk of Coronary Heart Disease Among U.S. Diabetic Men
Diabetes July 2006 55:2140-2147; doi:10.2337/db05-1535

New Methodologies and Databases

Select this article
- Antonios E. Panteleon,
- Mikhail Loutseiko,
- Garry M. Steil,
- and Kerstin Rebrin
Evaluation of the Effect of Gain on the Meal Response of an Automated Closed-Loop Insulin Delivery System
Diabetes July 2006 55:1995-2000; doi:10.2337/db05-1346

Metabolism

Select this article
- Rita Basu,
- Chiara Dalla Man,
- Marco Campioni,
- Ananda Basu,
- George Klee,
- Gianna Toffolo,
- Claudio Cobelli,
- and Robert A. Rizza
Effects of Age and Sex on Postprandial Glucose Metabolism: Differences in Glucose Turnover, Insulin Secretion, Insulin Action, and Hepatic Insulin Extraction
Diabetes July 2006 55:2001-2014; doi:10.2337/db05-1692
Select this article
- Peter J. Raubenheimer,
- Moffat J. Nyirenda,
- and Brian R. Walker
A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet
Diabetes July 2006 55:2015-2020; doi:10.2337/db06-0097
Select this article
- Francesco Andreozzi,
- Emanuela Laratta,
- Marina Cardellini,
- Maria A. Marini,
- Renato Lauro,
- Marta L. Hribal,
- Francesco Perticone,
- and Giorgio Sesti
Plasma Interleukin-6 Levels Are Independently Associated With Insulin Secretion in a Cohort of Italian-Caucasian Nondiabetic Subjects
Diabetes July 2006 55:2021-2024; doi:10.2337/db06-0063
Select this article
- Caterina Guidone,
- Melania Manco,
- Elena Valera-Mora,
- Amerigo Iaconelli,
- Donatella Gniuli,
- Andrea Mari,
- Giuseppe Nanni,
- Marco Castagneto,
- Menotti Calvani,
- and Geltrude Mingrone
Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery
Diabetes July 2006 55:2025-2031; doi:10.2337/db06-0068

Obesity Studies

Select this article
- Hiroaki Okazaki,
- Masaki Igarashi,
- Makiko Nishi,
- Makiko Tajima,
- Motohiro Sekiya,
- Sachiko Okazaki,
- Naoya Yahagi,
- Ken Ohashi,
- Kazuhisa Tsukamoto,
- Michiyo Amemiya-Kudo,
- Takashi Matsuzaka,
- Hitoshi Shimano,
- Nobuhiro Yamada,
- Junken Aoki,
- Rei Morikawa,
- Yasukazu Takanezawa,
- Hiroyuki Arai,
- Ryozo Nagai,
- Takashi Kadowaki,
- Jun-ichi Osuga,
- and Shun Ishibashi
Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol: A Potential Role in Adipocyte Lipolysis
Diabetes July 2006 55:2091-2097; doi:10.2337/db05-0585

Immunology and Transplantation

Select this article
- Pascale Alard,
- Jean N. Manirarora,
- Sarah A. Parnell,
- Jason L. Hudkins,
- Sherry L. Clark,
- and Michele M. Kosiewicz
Deficiency in NOD Antigen-Presenting Cell Function May Be Responsible for Suboptimal CD4⁺CD25⁺ T-Cell–Mediated Regulation and Type 1 Diabetes Development in NOD Mice
Diabetes July 2006 55:2098-2105; doi:10.2337/db05-0810

Brief Genetics Reports

Select this article
- Laura Andrulionytė,
- Paula Peltola,
- Jean-Louis Chiasson,
- and Markku Laakso
Single Nucleotide Polymorphisms of PPARD in Combination With the Gly482Ser Substitution of PGC-1A and the Pro12Ala Substitution of PPARG2 Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes: The STOP-NIDDM Trial
Diabetes July 2006 55:2148-2152; doi:10.2337/db05-1629
Select this article
- Helen C. Freeman,
- Alison Hugill,
- Neil T. Dear,
- Frances M. Ashcroft,
- and Roger D. Cox
Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice
Diabetes July 2006 55:2153-2156; doi:10.2337/db06-0358

Diabetes

Perspectives in Diabetes

Interventional Strategies to Prevent β-Cell Apoptosis in Islet Transplantation

Signal Transduction

Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice

A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells

Leptin Suppresses Stearoyl-CoA Desaturase 1 by Mechanisms Independent of Insulin and Sterol Regulatory Element–Binding Protein-1c

Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

Serum- and Glucocorticoid-Inducible Kinase 1 Mediates Salt Sensitivity of Glucose Tolerance

Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

The Role of Ca2+ Influx for Insulin-Mediated Glucose Uptake in Skeletal Muscle

Mitochondrial Reactive Oxygen Species Are Required for Hypothalamic Glucose Sensing

Islet Studies

Spontaneous Recovery From Hyperglycemia by Regeneration of Pancreatic β-Cells in Kir6.2G132S Transgenic Mice

β-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2 Diabetes

Pathophysiology

Cystic Fibrosis Transmembrane Conductance Regulator Deficiency Exacerbates Islet Cell Dysfunction After β-Cell Injury

Complications

Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH2-Terminal Kinase Activation, Depletion of Reduced Glutathione, Increased Superoxide Accumulation, and DNA Damage

Comparison of Serum High–Molecular Weight (HMW) Adiponectin With Total Adiponectin Concentrations in Type 2 Diabetic Patients With Coronary Artery Disease Using a Novel Enzyme-Linked Immunosorbent Assay to Detect HMW Adiponectin

Increased Dicarbonyl Metabolism in Endothelial Cells in Hyperglycemia Induces Anoikis and Impairs Angiogenesis by RGD and GFOGER Motif Modification

Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN

The Relationship Between Plasma Osteoprotegerin and Endothelium-Dependent Arterial Dilation in Type 2 Diabetes

ACE and ACE2 Activity in Diabetic Mice

Genetics

Common Hepatic Nuclear Factor-4α Variants Are Associated With High Serum Lipid Levels and the Metabolic Syndrome

Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2g7 Homozygosity, and Insulin 2 Gene Knockout

Coincident Linkage of Type 2 Diabetes, Metabolic Syndrome, and Measures of Cardiovascular Disease in a Genome Scan of the Diabetes Heart Study

Common Variants of the Endothelial Nitric Oxide Synthase Gene and the Risk of Coronary Heart Disease Among U.S. Diabetic Men

New Methodologies and Databases

Evaluation of the Effect of Gain on the Meal Response of an Automated Closed-Loop Insulin Delivery System

Metabolism

Effects of Age and Sex on Postprandial Glucose Metabolism: Differences in Glucose Turnover, Insulin Secretion, Insulin Action, and Hepatic Insulin Extraction

A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet

Plasma Interleukin-6 Levels Are Independently Associated With Insulin Secretion in a Cohort of Italian-Caucasian Nondiabetic Subjects

Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery

Obesity Studies

Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol: A Potential Role in Adipocyte Lipolysis

Immunology and Transplantation

Deficiency in NOD Antigen-Presenting Cell Function May Be Responsible for Suboptimal CD4+CD25+ T-Cell–Mediated Regulation and Type 1 Diabetes Development in NOD Mice

Brief Genetics Reports

Single Nucleotide Polymorphisms of PPARD in Combination With the Gly482Ser Substitution of PGC-1A and the Pro12Ala Substitution of PPARG2 Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes: The STOP-NIDDM Trial

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice

This Issue

Current Issue

The Role of Ca²⁺ Influx for Insulin-Mediated Glucose Uptake in Skeletal Muscle

Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH₂-Terminal Kinase Activation, Depletion of Reduced Glutathione, Increased Superoxide Accumulation, and DNA Damage

Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2^g7 Homozygosity, and Insulin 2 Gene Knockout

Deficiency in NOD Antigen-Presenting Cell Function May Be Responsible for Suboptimal CD4⁺CD25⁺ T-Cell–Mediated Regulation and Type 1 Diabetes Development in NOD Mice