Table of Contents

• David A. Antonetti,
• Alistair J. Barber,
• Sarah K. Bronson,
• Willard M. Freeman,
• Thomas W. Gardner,
• Leonard S. Jefferson,
• Mark Kester,
• Scot R. Kimball,
• J. Kyle Krady,
• Kathryn F. LaNoue,
• Christopher C. Norbury,
• Patrick G. Quinn,
• Lakshman Sandirasegarane,
• and Ian A. Simpson

Diabetic Retinopathy: Seeing Beyond Glucose-Induced Microvascular Disease

• Nadine L. Dudek,
• Helen E. Thomas,
• Lina Mariana,
• Robyn M. Sutherland,
• Janette Allison,
• Eugene Estella,
• Eveline Angstetra,
• Joseph A. Trapani,
• Pere Santamaria,
• Andrew M. Lew,
• and Thomas W.H. Kay

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

• Natalia V. Evgenov,
• Zdravka Medarova,
• John Pratt,
• Pamela Pantazopoulos,
• Simone Leyting,
• Susan Bonner-Weir,
• and Anna Moore

In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets

• Nan Zhang,
• Dongming Su,
• Shen Qu,
• Tonia Tse,
• Rita Bottino,
• A.N. Balamurugan,
• Jing Xu,
• Jonathan S. Bromberg,
• and H. Henry Dong

Sirolimus Is Associated With Reduced Islet Engraftment and Impaired β-Cell Function

• Vicki Seyfert-Margolis,
• Trang D. Gisler,
• Adam L. Asare,
• Richard S. Wang,
• H. Michael Dosch,
• Barbara Brooks-Worrell,
• George S. Eisenbarth,
• Jerry P. Palmer,
• Carla J. Greenbaum,
• Stephen E. Gitelman,
• Gerald T. Nepom,
• Jeffrey A. Bluestone,
• and Kevan C. Herold

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes: Results of a Blinded Controlled Study

• Michael O. Palumbo,
• Dina Levi,
• Aziz Alami Chentoufi,
• and Constantin Polychronakos

Isolation and Characterization of Proinsulin-Producing Medullary Thymic Epithelial Cell Clones

• Florencia M. Barbé-Tuana,
• Dagmar Klein,
• Hirohito Ichii,
• Dora M. Berman,
• Lane Coffey,
• Norma S. Kenyon,
• Camillo Ricordi,
• and Ricardo L. Pastori

CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets

• Andrei I. Tarasov,
• Christophe A.J. Girard,
• and Frances M. Ashcroft

ATP Sensitivity of the ATP-Sensitive K⁺ Channel in Intact and Permeabilized Pancreatic β-Cells

• Kathrin Maedler,
• Desiree M. Schumann,
• Fabienne Schulthess,
• José Oberholzer,
• Domenico Bosco,
• Thierry Berney,
• and Marc Y. Donath

Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1

• Ivan Quesada,
• Mariana G. Todorova,
• Paloma Alonso-Magdalena,
• Marta Beltrá,
• Everardo M. Carneiro,
• Franz Martin,
• Angel Nadal,
• and Bernat Soria

Glucose Induces Opposite Intracellular Ca²⁺ Concentration Oscillatory Patterns in Identified α- and β-Cells Within Intact Human Islets of Langerhans

• Wolf Wente,
• Alexander M. Efanov,
• Martin Brenner,
• Alexei Kharitonenkov,
• Anja Köster,
• George E. Sandusky,
• Sabine Sewing,
• Iris Treinies,
• Heike Zitzer,
• and Jesper Gromada

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

• Yuka Fujimoto,
• Tracy P. Torres,
• E. Patrick Donahue,
• and Masakazu Shiota

Glucose Toxicity Is Responsible for the Development of Impaired Regulation of Endogenous Glucose Production and Hepatic Glucokinase in Zucker Diabetic Fatty Rats

• David Liuwantara,
• Mark Elliot,
• Mariya W. Smith,
• Andrew O. Yam,
• Stacy N. Walters,
• Eliana Marino,
• Andy McShea,
• and Shane T. Grey

Nuclear Factor-κB Regulates β-Cell Death: A Critical Role for A20 in β-Cell Protection

• Gregory Proctor,
• Tao Jiang,
• Mieko Iwahashi,
• Zhuowei Wang,
• Jinping Li,
• and Moshe Levi

Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes

• Khin-Mar Myint,
• Yasuhiko Yamamoto,
• Toshio Doi,
• Ichiro Kato,
• Ai Harashima,
• Hideto Yonekura,
• Takuo Watanabe,
• Harumichi Shinohara,
• Masayoshi Takeuchi,
• Koichi Tsuneyama,
• Noriyoshi Hashimoto,
• Masahide Asano,
• Shin Takasawa,
• Hiroshi Okamoto,
• and Hiroshi Yamamoto

RAGE Control of Diabetic Nephropathy in a Mouse Model: Effects of RAGE Gene Disruption and Administration of Low–Molecular Weight Heparin

• Shu-lian Li,
• Marpadga A. Reddy,
• Qiangjun Cai,
• Li Meng,
• Hang Yuan,
• Linda Lanting,
• and Rama Natarajan

Enhanced Proatherogenic Responses in Macrophages and Vascular Smooth Muscle Cells Derived From Diabetic db/db Mice

• Gianpaolo Zerbini,
• Riccardo Bonfanti,
• Franco Meschi,
• Emilio Bognetti,
• Pier Luigi Paesano,
• Luigi Gianolli,
• Marialuisa Querques,
• Anna Maestroni,
• Giliola Calori,
• Alessandro Del Maschio,
• Ferruccio Fazio,
• Livio Luzi,
• and Giuseppe Chiumello

Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes

• Tamara Allen,
• Fang Zhang,
• Shonna A. Moodie,
• L. Edward Clemens,
• Aaron Smith,
• Francine Gregoire,
• Andrea Bell,
• George E.O. Muscat,
• and Thomas A. Gustafson

Halofenate Is a Selective Peroxisome Proliferator–Activated Receptor γ Modulator With Antidiabetic Activity

• Lori L. Bonnycastle,
• Cristen J. Willer,
• Karen N. Conneely,
• Anne U. Jackson,
• Cecily P. Burrill,
• Richard M. Watanabe,
• Peter S. Chines,
• Narisu Narisu,
• Laura J. Scott,
• Sareena T. Enloe,
• Amy J. Swift,
• William L. Duren,
• Heather M. Stringham,
• Michael R. Erdos,
• Nancy L. Riebow,
• Thomas A. Buchanan,
• Timo T. Valle,
• Jaakko Tuomilehto,
• Richard N. Bergman,
• Karen L. Mohlke,
• Michael Boehnke,
• and Francis S. Collins

Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns

• Eleftheria Zeggini,
• Coleen M. Damcott,
• Robert L. Hanson,
• Mohammad A. Karim,
• N. William Rayner,
• Christopher J. Groves,
• Leslie J. Baier,
• Terri C. Hale,
• Andrew T. Hattersley,
• Graham A. Hitman,
• Sarah E. Hunt,
• William C. Knowler,
• Braxton D. Mitchell,
• Maggie C.Y. Ng,
• Jeffrey R. O’Connell,
• Toni I. Pollin,
• Martine Vaxillaire,
• Mark Walker,
• Xiaoqin Wang,
• Pamela Whittaker,
• Kunsan Xiang,
• Weiping Jia,
• Juliana C. N. Chan,
• Philippe Froguel,
• Panos Deloukas,
• Alan R. Shuldiner,
• Steven C. Elbein,
• and Mark I. McCarthy

Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q

• Jacek Bochenski,
• Grzegorz Placha,
• Krzysztof Wanic,
• Maciej Malecki,
• Jacek Sieradzki,
• James H. Warram,
• and Andrzej S. Krolewski

New Polymorphism of ENPP1 (PC-1) Is Associated With Increased Risk of Type 2 Diabetes Among Obese Individuals

• Swapan Kumar Das,
• Winston S. Chu,
• Terri C. Hale,
• Xiaoqin Wang,
• Rebekah L. Craig,
• Hua Wang,
• Alan R. Shuldiner,
• Philippe Froguel,
• Panos Deloukas,
• Mark I. McCarthy,
• Eleftheria Zeggini,
• Sandra J. Hasstedt,
• and Steven C. Elbein

Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes

• I. Sadaf Farooqi,
• Stenvert Drop,
• Agnes Clements,
• Julia M. Keogh,
• Joanna Biernacka,
• Sarah Lowenbein,
• Benjamin G. Challis,
• and Stephen O’Rahilly

Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans

• Christopher J. Groves,
• Eleftheria Zeggini,
• Jayne Minton,
• Timothy M. Frayling,
• Michael N. Weedon,
• Nigel W. Rayner,
• Graham A. Hitman,
• Mark Walker,
• Steven Wiltshire,
• Andrew T. Hattersley,
• and Mark I. McCarthy

Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

• Cuilin Zhang,
• Lu Qi,
• David J. Hunter,
• James B. Meigs,
• JoAnn E. Manson,
• Rob M. van Dam,
• and Frank B. Hu

Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men

• Laura J. Scott,
• Lori L. Bonnycastle,
• Cristen J. Willer,
• Andrew G. Sprau,
• Anne U. Jackson,
• Narisu Narisu,
• William L. Duren,
• Peter S. Chines,
• Heather M. Stringham,
• Michael R. Erdos,
• Timo T. Valle,
• Jaakko Tuomilehto,
• Richard N. Bergman,
• Karen L. Mohlke,
• Francis S. Collins,
• and Michael Boehnke

Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample

• Coleen M. Damcott,
• Toni I. Pollin,
• Laurie J. Reinhart,
• Sandra H. Ott,
• Haiqing Shen,
• Kristi D. Silver,
• Braxton D. Mitchell,
• and Alan R. Shuldiner

Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish: Replication and Evidence for a Role in Both Insulin Secretion and Insulin Resistance

• Daniel P.K. Ng,
• Grzegorz Placha,
• Serena Choo,
• Kee-seng Chia,
• James H. Warram,
• and Andrzej S. Krolewski

A Disease Haplotype for Advanced Nephropathy in Type 2 Diabetes at the ACE Locus

• Marcelo B.S. Flores,
• Maria Fernanda A. Fernandes,
• Eduardo R. Ropelle,
• Marcel C. Faria,
• Mirian Ueno,
• Lício A. Velloso,
• Mario J.A. Saad,
• and José B.C. Carvalheira

Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats

• Myeong Jin Yoon,
• Gha Young Lee,
• Jun-Jae Chung,
• Young Ho Ahn,
• Seung Hwan Hong,
• and Jae Bum Kim

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

• Tamara Tchkonia,
• Nino Giorgadze,
• Tamar Pirtskhalava,
• Thomas Thomou,
• Matthew DePonte,
• Ada Koo,
• R. Armour Forse,
• Dharmaraj Chinnappan,
• Carmen Martin-Ruiz,
• Thomas von Zglinicki,
• and James L. Kirkland

Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes

• Fahumiya Samad,
• Kelly D. Hester,
• Guang Yang,
• Yusuf A. Hannun,
• and Jacek Bielawski

Altered Adipose and Plasma Sphingolipid Metabolism in Obesity: A Potential Mechanism for Cardiovascular and Metabolic Risk

• Juan M. Castellano,
• Victor M. Navarro,
• Rafael Fernández-Fernández,
• Juan Roa,
• Eva Vigo,
• Rafael Pineda,
• Carlos Dieguez,
• Enrique Aguilar,
• Leonor Pinilla,
• and Manuel Tena-Sempere

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

• Franz M. Matschinsky

Retraction

Errata