Table of Contents

Editorial

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- James Levine
Obesity: Mission Possible
Diabetes November 2007 56:2653-2654; doi:10.2337/db07-0951

Perspectives in Diabetes

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- Marc T. Hamilton,
- Deborah G. Hamilton,
- and Theodore W. Zderic
Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease
Diabetes November 2007 56:2655-2667; published ahead of print September 7, 2007, doi:10.2337/db07-0882
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- C. Ford Runge
Economic Consequences of the Obese
Diabetes November 2007 56:2668-2672; published ahead of print June 29, 2007, doi:10.2337/db07-0633
Select this article
- Robert W. Jeffery and
- Lisa J. Harnack
Evidence Implicating Eating as a Primary Driver for the Obesity Epidemic
Diabetes November 2007 56:2673-2676; published ahead of print September 18, 2007, doi:10.2337/db07-1029

New Methodologies and Databases

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- Zdravka Medarova,
- Gerardo Castillo,
- Guangping Dai,
- Elijah Bolotin,
- Alexei Bogdanov,
- and Anna Moore
Noninvasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes
Diabetes November 2007 56:2677-2682; published ahead of print August 6, 2007, doi:10.2337/db07-0822

Metabolism

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- Helen Karakelides,
- Yan W. Asmann,
- Maureen L. Bigelow,
- Kevin R. Short,
- Ketan Dhatariya,
- Jill Coenen-Schimke,
- Jane Kahl,
- Debabrata Mukhopadhyay,
- and K. Sreekumaran Nair
Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects
Diabetes November 2007 56:2683-2689; published ahead of print July 27, 2007, doi:10.2337/db07-0378
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- Eric Le Gouill,
- Maria Jimenez,
- Christophe Binnert,
- Pierre-Yves Jayet,
- Sebastien Thalmann,
- Pascal Nicod,
- Urs Scherrer,
- and Peter Vollenweider
Endothelial Nitric Oxide Synthase (eNOS) Knockout Mice Have Defective Mitochondrial β-Oxidation
Diabetes November 2007 56:2690-2696; published ahead of print August 6, 2007, doi:10.2337/db06-1228
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- Scott M. Nelson,
- Naveed Sattar,
- Dilys J. Freeman,
- James D. Walker,
- and Robert S. Lindsay
Inflammation and Endothelial Activation Is Evident at Birth in Offspring of Mothers With Type 1 Diabetes
Diabetes November 2007 56:2697-2704; published ahead of print August 17, 2007, doi:10.2337/db07-0662
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- Scott M. Nelson,
- Dilys J. Freeman,
- Naveed Sattar,
- Frank D. Johnstone,
- and Robert S. Lindsay
IGF-1 and Leptin Associate With Fetal HDL Cholesterol at Birth: Examination in Offspring of Mothers With Type 1 Diabetes
Diabetes November 2007 56:2705-2709; published ahead of print July 31, 2007, doi:10.2337/db07-0585
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- Pernille Poulsen,
- Jørgen F.P. Wojtaszewski,
- Erik A. Richter,
- Henning Beck-Nielsen,
- and Allan Vaag
Low Birth Weight and Zygosity Status Is Associated With Defective Muscle Glycogen and Glycogen Synthase Regulation in Elderly Twins
Diabetes November 2007 56:2710-2714; published ahead of print August 13, 2007, doi:10.2337/db07-0155

Original Article

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- Carol Wadham,
- Angela Parker,
- Lijun Wang,
- and Pu Xia
High Glucose Attenuates Protein S-Nitrosylation in Endothelial Cells: Role of Oxidative Stress
Diabetes November 2007 56:2715-2721; published ahead of print August 17, 2007, doi:10.2337/db06-1294

Islet Studies

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- Christine Tang,
- Ping Han,
- Andrei I. Oprescu,
- Simon C. Lee,
- Armen V. Gyulkhandanyan,
- Gary N.Y. Chan,
- Michael B. Wheeler,
- and Adria Giacca
Evidence for a Role of Superoxide Generation in Glucose-Induced β-Cell Dysfunction In Vivo
Diabetes November 2007 56:2722-2731; published ahead of print August 6, 2007, doi:10.2337/db07-0279
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- Rupangi C. Vasavada,
- Lin Wang,
- Yuichi Fujinaka,
- Karen K. Takane,
- Taylor C. Rosa,
- Jose M.D. Mellado-Gil,
- Peter A. Friedman,
- and Adolfo Garcia-Ocaña
Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation: An Essential Role in Growth Factor–Mediated β-Cell Mitogenesis
Diabetes November 2007 56:2732-2743; published ahead of print August 8, 2007, doi:10.2337/db07-0461
Select this article
- Rhonda D. Wideman,
- Scott D. Covey,
- Gene C. Webb,
- Daniel J. Drucker,
- and Timothy J. Kieffer
A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice
Diabetes November 2007 56:2744-2752; published ahead of print August 13, 2007, doi:10.2337/db07-0563

Pathophysiology

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- Kamakshi Sachidanandam,
- Vera Portik-Dobos,
- Alex K. Harris,
- Jim R. Hutchinson,
- Erin Muller,
- Maribeth H. Johnson,
- and Adviye Ergul
Evidence for Vasculoprotective Effects of ET_B Receptors in Resistance Artery Remodeling in Diabetes
Diabetes November 2007 56:2753-2758; published ahead of print August 1, 2007, doi:10.2337/db07-0426
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- Jukka Westerbacka,
- Maria Kolak,
- Tuula Kiviluoto,
- Perttu Arkkila,
- Jukka Sirén,
- Anders Hamsten,
- Rachel M. Fisher,
- and Hannele Yki-Järvinen
Genes Involved in Fatty Acid Partitioning and Binding, Lipolysis, Monocyte/Macrophage Recruitment, and Inflammation Are Overexpressed in the Human Fatty Liver of Insulin-Resistant Subjects
Diabetes November 2007 56:2759-2765; published ahead of print August 17, 2007, doi:10.2337/db07-0156

Complications

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- Joel T. Dunn,
- Iain Cranston,
- Paul K. Marsden,
- Stephanie A. Amiel,
- and Laurence J. Reed
Attenuation of Amydgala and Frontal Cortical Responses to Low Blood Glucose Concentration in Asymptomatic Hypoglycemia in Type 1 Diabetes: A New Player in Hypoglycemia Unawareness?
Diabetes November 2007 56:2766-2773; published ahead of print July 27, 2007, doi:10.2337/db07-0666
Select this article
- David M. Maahs,
- Lorraine G. Ogden,
- Adam Kretowski,
- Janet K. Snell-Bergeon,
- Gregory L. Kinney,
- Tomas Berl,
- and Marian Rewers
Serum Cystatin C Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals With Type 1 Diabetes
Diabetes November 2007 56:2774-2779; published ahead of print July 27, 2007, doi:10.2337/db07-0539
Select this article
- Zhongju Lu,
- Ya-Ping Jiang,
- Xin-Hua Xu,
- Lisa M. Ballou,
- Ira S. Cohen,
- and Richard Z. Lin
Decreased l-Type Ca²⁺ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling
Diabetes November 2007 56:2780-2789; published ahead of print July 31, 2007, doi:10.2337/db06-1629
Select this article
- Sridevi Devaraj,
- Anthony T. Cheung,
- Ishwarlal Jialal,
- Steven C. Griffen,
- Danh Nguyen,
- Nicole Glaser,
- and Thomas Aoki
Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients With Type 1 Diabetes and Their Role in Microvascular Complications
Diabetes November 2007 56:2790-2796; published ahead of print August 8, 2007, doi:10.2337/db07-0784

Pharmacology and Therapeutics

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- Maria Carmen Carmona,
- Katie Louche,
- Bruno Lefebvre,
- Antoine Pilon,
- Nathalie Hennuyer,
- Véronique Audinot-Bouchez,
- Catherine Fievet,
- Gérard Torpier,
- Pierre Formstecher,
- Pierre Renard,
- Philippe Lefebvre,
- Catherine Dacquet,
- Bart Staels,
- Louis Casteilla,
- and Luc Pénicaud
S 26948: a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects
Diabetes November 2007 56:2797-2808; published ahead of print August 17, 2007, doi:10.2337/db06-1734
Select this article
- Chiuhui Mary Wang,
- Jill Lincoln,
- Jeremy E. Cook,
- and David L. Becker
Abnormal Connexin Expression Underlies Delayed Wound Healing in Diabetic Skin
Diabetes November 2007 56:2809-2817; published ahead of print August 23, 2007, doi:10.2337/db07-0613

Genetics

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- Sobha Puppala,
- Rector Arya,
- Farook Thameem,
- Nedal H. Arar,
- Kusum Bhandari,
- Donna M. Lehman,
- Jennifer Schneider,
- Sharon Fowler,
- Vidya S. Farook,
- Vincent P. Diego,
- Laura Almasy,
- John Blangero,
- Michael P. Stern,
- Ravindranath Duggirala,
- and Hanna E. Abboud
Genotype by Diabetes Interaction Effects on the Detection of Linkage of Glomerular Filtration Rate to a Region on Chromosome 2q in Mexican Americans
Diabetes November 2007 56:2818-2828; published ahead of print August 13, 2007, doi:10.2337/db06-0984
Select this article
- Yasufumi Doi,
- Michiaki Kubo,
- Toshiharu Ninomiya,
- Koji Yonemoto,
- Masanori Iwase,
- Hisatomi Arima,
- Jun Hata,
- Yumihiro Tanizaki,
- Mitsuo Iida,
- and Yutaka Kiyohara
Impact of Kir6.2 E23K Polymorphism on the Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study
Diabetes November 2007 56:2829-2833; published ahead of print August 17, 2007, doi:10.2337/db07-1709
Select this article
- Masaaki Ochi,
- Haruhiko Osawa,
- Yushi Hirota,
- Kazuo Hara,
- Yasuharu Tabara,
- Yoshiharu Tokuyama,
- Ikki Shimizu,
- Azuma Kanatsuka,
- Yasuhisa Fujii,
- Jun Ohashi,
- Tetsuro Miki,
- Naoto Nakamura,
- Takashi Kadowaki,
- Mitsuo Itakura,
- Masato Kasuga,
- and Hideichi Makino
Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes
Diabetes November 2007 56:2834-2838; published ahead of print August 13, 2007, doi:10.2337/db06-1157

Editorial

Obesity: Mission Possible

Perspectives in Diabetes

Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease

Economic Consequences of the Obese

Evidence Implicating Eating as a Primary Driver for the Obesity Epidemic

New Methodologies and Databases

Noninvasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes

Metabolism

Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects

Endothelial Nitric Oxide Synthase (eNOS) Knockout Mice Have Defective Mitochondrial β-Oxidation

Inflammation and Endothelial Activation Is Evident at Birth in Offspring of Mothers With Type 1 Diabetes

IGF-1 and Leptin Associate With Fetal HDL Cholesterol at Birth: Examination in Offspring of Mothers With Type 1 Diabetes

Low Birth Weight and Zygosity Status Is Associated With Defective Muscle Glycogen and Glycogen Synthase Regulation in Elderly Twins

Original Article

High Glucose Attenuates Protein S-Nitrosylation in Endothelial Cells: Role of Oxidative Stress

Islet Studies

Evidence for a Role of Superoxide Generation in Glucose-Induced β-Cell Dysfunction In Vivo

Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation: An Essential Role in Growth Factor–Mediated β-Cell Mitogenesis

A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice

Pathophysiology

Evidence for Vasculoprotective Effects of ET_B Receptors in Resistance Artery Remodeling in Diabetes

Genes Involved in Fatty Acid Partitioning and Binding, Lipolysis, Monocyte/Macrophage Recruitment, and Inflammation Are Overexpressed in the Human Fatty Liver of Insulin-Resistant Subjects

Complications

Attenuation of Amydgala and Frontal Cortical Responses to Low Blood Glucose Concentration in Asymptomatic Hypoglycemia in Type 1 Diabetes: A New Player in Hypoglycemia Unawareness?

Serum Cystatin C Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals With Type 1 Diabetes

Decreased l-Type Ca²⁺ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling

Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients With Type 1 Diabetes and Their Role in Microvascular Complications

Pharmacology and Therapeutics

S 26948: a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects

Abnormal Connexin Expression Underlies Delayed Wound Healing in Diabetic Skin

Genetics

Genotype by Diabetes Interaction Effects on the Detection of Linkage of Glomerular Filtration Rate to a Region on Chromosome 2q in Mexican Americans

Impact of Kir6.2 E23K Polymorphism on the Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study

Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes

This Issue

Current Issue

Table of Contents

Editorial

Obesity: Mission Possible

Perspectives in Diabetes

Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease

Economic Consequences of the Obese

Evidence Implicating Eating as a Primary Driver for the Obesity Epidemic

New Methodologies and Databases

Noninvasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes

Metabolism

Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects

Endothelial Nitric Oxide Synthase (eNOS) Knockout Mice Have Defective Mitochondrial β-Oxidation

Inflammation and Endothelial Activation Is Evident at Birth in Offspring of Mothers With Type 1 Diabetes

IGF-1 and Leptin Associate With Fetal HDL Cholesterol at Birth: Examination in Offspring of Mothers With Type 1 Diabetes

Low Birth Weight and Zygosity Status Is Associated With Defective Muscle Glycogen and Glycogen Synthase Regulation in Elderly Twins

Original Article

High Glucose Attenuates Protein S-Nitrosylation in Endothelial Cells: Role of Oxidative Stress

Islet Studies

Evidence for a Role of Superoxide Generation in Glucose-Induced β-Cell Dysfunction In Vivo

Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation: An Essential Role in Growth Factor–Mediated β-Cell Mitogenesis

A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice

Pathophysiology

Evidence for Vasculoprotective Effects of ETB Receptors in Resistance Artery Remodeling in Diabetes

Genes Involved in Fatty Acid Partitioning and Binding, Lipolysis, Monocyte/Macrophage Recruitment, and Inflammation Are Overexpressed in the Human Fatty Liver of Insulin-Resistant Subjects

Complications

Attenuation of Amydgala and Frontal Cortical Responses to Low Blood Glucose Concentration in Asymptomatic Hypoglycemia in Type 1 Diabetes: A New Player in Hypoglycemia Unawareness?

Serum Cystatin C Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals With Type 1 Diabetes

Decreased l-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling

Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients With Type 1 Diabetes and Their Role in Microvascular Complications

Pharmacology and Therapeutics

S 26948: a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects

Abnormal Connexin Expression Underlies Delayed Wound Healing in Diabetic Skin

Genetics

Genotype by Diabetes Interaction Effects on the Detection of Linkage of Glomerular Filtration Rate to a Region on Chromosome 2q in Mexican Americans

Impact of Kir6.2 E23K Polymorphism on the Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study

Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes

This Issue

Current Issue

Evidence for Vasculoprotective Effects of ET_B Receptors in Resistance Artery Remodeling in Diabetes

Decreased l-Type Ca²⁺ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling