Comment on: Chang et al. (2007) Association Study of the Genetic Polymorphisms of the Transcription Factor 7-like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population: Diabetes 56:2631–2637
- From the Center for Molecular Epidemiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
- Address correspondence and reprint requests to Chee-Seng Ku, Center for Molecular Epidemiology, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Dr., Singapore 117597. E-mail: cmekcs{at}nus.edu.sg
We read with interest the article by Chang et al. (1), who were the first group to report a novel allelic association (rs290487) of the TCF7L2 gene with type 2 diabetes in the Han Chinese population (1). The link between the TCF7L2 gene and type 2 diabetes in Caucasians was first reported by deCODE genetics through the fine-mapping of a previously identified suggestive linkage region on chromosome 10q. Two highly significant single nucleotide polymorphisms (SNPs), rs12255372 T-allele and rs7903146 T-allele, were reported to be in strong linkage disequilibrium with the microsatellite DG10S478. Therefore, the deCODE genetics authors recommended that these two SNPs be genotyped …
